Can SARMs Cause Gyno?
One very common question I get asked is about SARMs and high Estrogen side effects.
One of the biggest myths circulating in the community is that SARMs cannot cause Estrogen related side effects because they don’t aromatize into Estrogen, and if you do experience high Estrogen side effects then you have “fake SARMs” or “Prohormone laced SARMs.”
The majority of the time, this couldn’t be further from the truth and is a simple misunderstanding of the mechanism of action of these compounds, and how they interact with the androgen receptors in the body.
Remember, SARMs were developed to have a very high binding affinity to the androgen receptor.
One thing that isn’t taken into account is that their binding affinity is much higher than most steroids, including the steroids your body naturally produces (Testosterone & DHT).
When the human body’s androgen receptors are flooded with SARMs that bind tightly, there are less vacant androgen receptors for the Testosterone in your body to bind to, which ultimately can divert a greater amount of Testosterone to convert into Estrogen and DHT.
In addition, the higher your dose of SARMs, the more your available Testosterone will be diverted towards Estrogen and DHT conversion, as there are less vacant androgen receptors the higher your dosage of SARMs are.
When this scenario unfolds and Estrogen rises to out of range levels, one puts themselves at risk of a myriad of side effects caused by high Estrogen levels, including gynecomastia (gyno).
This is why it would be prudent to take a mild Aromatase Inhibitor (AI) on cycle alongside your SARMs to mitigate your Estrogen from getting too high and out of range.
Keep in mind, if you are not using exogenous anabolics, you only have to worry about an increased level of conversion from your natural Testosterone levels, hence using an Aromatase Inhibitor like Arimidex or Letrozole during a SARM only cycle would be complete overkill and totally unnecessary, and would likely just do more harm than good with a high likelihood of crashing your Estrogen levels.
Aromasin would also likely be overkill unless you already have a genetic propensity to high out of range Estrogen aromatization off of SARMs.
Arimistane (Androsta-3,5-diene-7,17-dione) is a very mild over the counter AI that you can use with SARM only cycles to keep your Estrogen in the sweet spot.
It has a high margin of error, is legal (the other AI’s mentioned are Rx only), and is just strong enough to deal with an increased level of Estrogen aromatization, but not too strong that it would crash one’s Estrogen unless they used far too much in almost all cases.
A standard on cycle dosage for Estrogen control during a SARM only cycle would be 25mg of Arimistane per day.
A more aggressive dosage for those who may be more genetically prone to higher Estrogen levels would be 50mg-75mg per day.
Obviously the dose of your AI will be dependent on your Estrogen levels, but typically 25-75mg of Arimistane is sufficient for any SARM user, and it is a very mild and forgiving AI so it will be difficult to overdo it and tank your Estrogen if you stay in that range.
The only way to 100% accurately figure out what dose works best for you is via blood work (ideally you want your Estrogen between 20-30 pg/mL, at least that’s where I feel best).
Once I start getting too low below that, low Estrogen side effects kick in, and when I get too far above that, high Estrogen side effects kick in.
When using something like Aromasin, and especially Arimidex, and even more so Letrozole, they are increasingly difficult to hit the nail on the head in terms of bringing your Estrogen into the sweet spot.
Not to mention Arimidex and Letrozole are horrible for your lipid profile, so Arimistane is always the ideal AI of choice during a SARM cycle.
Unless you also have an abnormally high level of aromatization naturally in your body, then and only then would something like Aromasin be necessary in my opinion.
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Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. These products are intended as research chemicals only.