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Can SARMs Cause Gyno? – Revealing How SARMs Can Cause Gynecomastia & How To Protect Yourself

Can SARMs Cause Gyno?

One very common question I get asked is about SARMs and high Estrogen side effects.

One of the biggest myths circulating in the community is that SARMs cannot cause Estrogen related side effects because they don’t aromatize into Estrogen, and if you do experience high Estrogen side effects then you have “fake SARMs” or “Prohormone laced SARMs.”

The majority of the time, this couldn’t be further from the truth and is a simple misunderstanding of the mechanism of action of these compounds, and how they interact with the androgen receptors in the body.

Remember, SARMs were developed to have a very high binding affinity to the androgen receptor.

Some SARMs have a binding affinity formidable to that of powerful steroids.

When the human body’s androgen receptors are flooded with SARMs that bind tightly, there are less vacant androgen receptors for the Testosterone in your body to bind to, which ultimately can divert a greater amount of Testosterone to convert into Estrogen and DHT.

In addition, the higher your dose of SARMs, the more your available Testosterone will be diverted towards Estrogen and DHT conversion, as there are less vacant androgen receptors the higher your dosage of SARMs are.

When this scenario unfolds and Estrogen rises to out of range levels, one puts themselves at risk of a myriad of side effects caused by high Estrogen levels, including gynecomastia (gyno).

SARMs also cause Testosterone suppression in a dose dependent manner.

If Testosterone levels plummet in the body and a hormonal imbalance occurs where the amount of Testosterone present is too low relative to Estrogen, that can cause gyno as well.

Anytime Testosterone levels or Estrogen levels are not in balance with one another and there's a state of Estrogen dominance, you are prone to gyno.

This is why some may find it necessary to take a mild Aromatase Inhibitor (AI) on cycle alongside SARMs to prevent an Androgen to Estrogen imbalance.

Keep in mind, if you are not using exogenous anabolics, you only have to worry about an increased level of conversion from your natural Testosterone levels, hence using an Aromatase Inhibitor like Arimidex or Letrozole during a SARM only cycle would be complete overkill and totally unnecessary, and would likely just do more harm than good with a high likelihood of crashing your Estrogen levels.

Aromasin would also likely be overkill unless you already have a genetic propensity to high out of range Estrogen aromatization off of SARMs.

Arimistane (Androsta-3,5-diene-7,17-dione) is a very mild over the counter AI that you can use with SARM only cycles to keep your Estrogen in the sweet spot.

It has a high margin of error, is legal (the other AI’s mentioned are Rx only), and is just strong enough to deal with an increased level of Estrogen aromatization, but not too strong that it would crash one’s Estrogen unless they used far too much in almost all cases.

A standard on cycle dosage for Estrogen control during a SARM only cycle would be 25mg of Arimistane per day.

A more aggressive dosage for those who may be more genetically prone to higher Estrogen levels would be 50mg-75mg per day.

Obviously the dose of your AI will be dependent on your Estrogen levels, but typically 25-75mg of Arimistane is sufficient for any SARM user, and it is a very mild and forgiving AI so it will be difficult to overdo it and tank your Estrogen if you stay in that range.

The only way to 100% accurately figure out what dose works best for you is via blood work (ideally you want your Estrogen between 20-30 pg/mL, at least that’s where I feel best).

Once I start getting too low below that, low Estrogen side effects kick in, and when I get too far above that, high Estrogen side effects kick in.

When using something like Aromasin, and especially Arimidex, and even more so Letrozole, they are increasingly difficult to hit the nail on the head in terms of bringing your Estrogen into the sweet spot.

Unless you also have an abnormally high level of aromatization naturally in your body, then and only then would something like Aromasin be necessary in my opinion.

Where To Buy Third Party Tested SARMs

Most SARMs sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I highly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure SARMs:

Proven Peptides – 10% off coupon code “DC10”

Chemyo

Narrows Labs – 25% off coupon code “DC25”

Androbolics Canada (CAD Currency)

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Be sure to check all laws in your country prior to buying anything to make sure it is compliant where you live with your current government laws.

36 thoughts on “Can SARMs Cause Gyno? – Revealing How SARMs Can Cause Gynecomastia & How To Protect Yourself”

  1. If I already have Nolvadex and Chlomid as part of an EA stack, can I use a little bit of Nolvadex at the beginning of the cycle instead?

    1. Perhaps for an Osta only cycle if you are young and can bounce back fairly quickly. Otherwise I wouldn’t advise using that for PCT.

  2. Hello Derek,

    Funny my name is the same. I am currently taking 30mg Osta, for the past 8 weeks and now just added RAD for the remaining 4 weeks. I am taking 50 mg Arimistan per day while taking these. When I’m done, with the SARMs, will I need Clomid and Nova to PCT? Any help would be appreciated

  3. I decided to do s-23, Ostarine and Cardarine. Ran for about 4 weeks. I decided to discontinue s-23 and continue my cut by weening down to just Ostarine, Cardarine, and sr9009. I started taking Arimistane to start counter acting the shutdown effects of s-23. I am feeling a little bit nipple pains when not taking a dose of Arimistane in a 12 hour period. Should I get back on s-23 and finish with Clomid and nova after or is this okay since Ostarine is still suppressive as well.
    Or should i go ahead with clomid and nova now and stop everything all together?

    I know this is bit of a winded question just trying to prevent any Gyno. I really appreciate the advice you give, probably the best I’ve seen so far.

    1. – If you get back on S23 is up to you
      – If you have gyno symptoms occurring, you aren’t getting your estrogen in range, increase your Arimistane dosage to 50 or 75mg, and if that isn’t sufficient then you will need Aromasin. Keeping your estrogen in range is what prevents gyno.
      – Nolva + Clomid is a good PCT yes.

  4. Hi Derek!

    Are some SARMS more likely than others to cause estro related sides?

    What 2 and 3 compound stacks would you recommend for cutting, that has the lowest chance for any sides?

    Best Regards

    1. The ones that shut you down completely vs slightly suppress will have a different influence on estrogen related side effects.

      Ostarine and S4.

        1. Depends what your pre-cycle bloods are and your propensity to suppression. Some guys can get totally shut down on LGD-4033, whereas others have no issues at all and experience minor suppression. The only SARM off the top of my head that will shut you down completely no matter how prone you are to suppression or not is S23.

  5. Hi Derek, love your videos.

    I bought ostamuscle from enhanced athlete and on the 5 days of use noticed I have higher estrogen symptoms, libido lost, tiredness, more emotional, and the worst, my nipples look pudgier and when I flex my chest I can see on the outside of my nipple towards my arm seems to be excess skin or fat.

    Now it isn’t apparent to my friends unless I really point it out, but it seems like I’m getting gyno symptoms.
    I’m 25 yrs old, 5”5 at 162lbs at around 15% body fat or so.

    I was using 10mg a day then bumped it up to 20 for 2 days, I just bought arimastain off amazon and am getting it today.

    Are these gyno symptoms I’m getting reversible? It’s definitely mild at best.

    Should I stop taking the ostarine cold turkey or lower the dosage? Should I move on to something strong than the arimistain?

    1. Yes, you can’t develop full blown gyno in 5 days so just start the Arimistane at 25 mg and see if they go away, if not, bump to 50, if not, bump to 75, if at that point you still have estrogen issues (ideally confirmed by blood work) then you could justify going up to something stronger (a low dosage of Aromasin likely being the ideal candidate).

  6. I am 20 years old and recently completed my third LGD cycle @12mg for 4 weeks. Due to complications I wasn’t allowed to take my pct for around a week (took it for the first week and missed the second). Could this be a big problem? I am back on PCT now but am worried that gyno may have started to form slightly on my right side due to a little difference in texture, however it isn’t visually noticeable and is extremely mild (could possibly not even be gyno and just in my head). Would missing 1 week of PCT cause this even with taking it the week before? Would continuing the PCT reverse this over time? Thanks for your time!

  7. How long does it take for estrogen like affects to take place with Ostarine. I have been taking ostarine for 5 days at 10mg and feel a fiery sensation around my nipples multiple times a day. I started taking Adrosta at 50mg and 75mg for a couple days and still getting the sensation. I have taken ostarine a couple times over the last 2 years and it seems like my symptoms get worse and faster each time. Always off at least 6 months before I take it. Any ideas? I even experienced mild hair loss the last cycle.

    1. Fiery sensation doesn’t sound anything like gyno to me. Gyno is obvious, your nips get way more sensitive and painful to the touch, and when it gets bad you can feel a physical lump forming underneath.

      You’d have to get a blood test to indicate if what you’re experiencing has anything to do with Estrogen in the first place. Judging without bloods is like taking shots in the dark.

      Ostarine builds up in the system very fast due to it’s half-life, so any potential Estrogen issues would likely start compounding after just a few days on it. Likely getting worse the longer you are on it/the longer and further you suppress your endocrine system.

  8. Im looking to run LGD 4033 for 4 week

    Then im going to run RAD 140 for 4 weeks to make it an 8 week cycle not 4 weeks

    And what pct is need

  9. At last someone who is completely confirming what I ve always know. SARMS can cause gyno.

    I developed an first itchy sore nipple after running Osta after an Epistane cycle. This has resulted in a small lump which can be tender to touch. I now have slightly puffy nipples when I’m warm, but it is not noticeable when I’m cold. The lump can still be felt underneath the nipple. When running short cycles of Epi or a standalone Arimistane cycle improves the situation in the short term but its always returns post cycle.

    I am just about to start your (Derek) raloxifine protocol to attempt to reduce the lump and restore my nipples to a less puffy state.

    I’ll let you know how it goes. I have 112 60mg raloxifine tablets.

  10. Derek Can you help me here please,
    I am 5”8, 22 and 60kg. I recently just purchased LDG-4033 haven’t used it yet. I’m just wondering does the cause Gyno and is a PCT cycle necessary after the 6 weeks?
    I really need this answered becuase im worried as I’ve only ever taking protein.
    Regards
    Rory

  11. Hi

    I have never done steroids or Sarms in my life, i purchased the pre workout myo TKO which has 5mg of ostarine in it per serving.

    Would i need to take an Al or a PCT using the pre workout?

    Thanks in advance

    1. I would never take a pre-workout spiked with SARMs, I don’t really have any advice on that to be honest. Sounds like a sketch product and I wouldn’t use it.

  12. The link above for the REPP Sports Arimivar (arimistane) seems no longer valid. Many products on Amazon claim anti-estrogen properties but I don’t see Arimistane listed in ingredients. Can you recommend or provide a link for another source of Arimistane?

    Thanks for your time.

  13. This is crazy. Just got my blood results back after 12 weeks of Ostarine by proven peptides. T was 170, E was over 3500! This makes no sense as I’m having no symptoms which would probably be present in either of those. No Gyno, good libido, no ED etc…I’m getting another test done to confirm, but have you heard of anything like this??

  14. Hi Derek.

    I’ve read your article above. Thanks for posting it.

    I’ve just started Ostarine, 15mg dosage. Never taken PEDs before. Trying to lose fat, retain muscle at the moment. Feels like it’s working, endurance higher, strength higher etc.

    2 things:

    1) Only negative side I am experiencing is I’ve had some mild stomach upset/gas/bloating. Is this normal? (Positive side – I feel better psychologically)

    2) When is a good time to check bloodwork? I am on day 3 of my first cycle. Should I do bloodwork now to check test and estrogen levels or should I wait a while longer? Of course, I am trying to prevent gyno like everybody else. (I have had pre-cycle bloods already to compare to baseline. Everything was in range, Test maybe on the lower side)

    Thank you for your time.
    Dave

    1. If you’re asking if SARMs have a negative effect on BG fluctuations, I don’t believe they do. Can someone with type 2 diabetes safely take them? That’s a question for a qualified medical professional.

  15. Hey derek, so i was doing rad140 10mg bumped it to 20 after 4 weeks because of no results, week 6 came around and i had lots of sides and felt like shit and noticed my nipples were way puffier than normal, week 7 now i can definitely feel a small lump when i pinch behind my nipple and visually see it in the mirror, i just stopped taking it yesterday and ordered nolva 20mg for 4 weeks that should be here tomorrow and ordering raloxifene today hopefully will have it in 3 days and take that at 60mg i read someone say ralox got rid of there gyno completely, im going to get my blood tested hopefully tomorrow although i dont know if theres even a point in doing that anymore because i already have the gyno, do you think it is at all possible for me to get rid of it completely or should i just accept that its to late and all i can do is maybe shrink it a little, also do you think getting my blood tested could help ?

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