David Sinclair is a professor of genetics at the forefront of anti-aging research.
I've taken note of his work, and as someone extremely interested in maximizing my longevity and vitality, I have incorporated a couple of his daily supplements into my own routine that I wasn't already using.
These are the supplements and drugs he uses to preserve his youth.
David Sinclair's takes 500 mg of Resveratrol with yogurt upon waking up.
Resveratrol is a natural phenol produced by plants when they are under attack by pathogens, or in response to injury.
It is essentially produced as a defense mechanism, and interestingly enough, when humans ingest it, it is purported to produce a similar hormetic that activates certain longevity pathways.
In addition to Resveratrol, David Sinclair takes one gram (1,000 mg) of Nicotinamide Mononucleotide (NMN) at the same time each morning with his homemade yogurt.
A common misconception is that NMN is the same as NR (Nicotinamide Riboside), and they are often confused with one another.
The main difference between the two is the molecule size, which will likely impact how it is absorbed and assimilated.
People often get confused between the two and they'll buy NR supplements, and think that they're getting NMN, but that's often not the case.
I'm not going to say one is superior to the other because NMN has less data on it than NR.
NR is the one that has human trials to show that it boosts NAD+ a significant amount.
There's going to be more data coming on NMN in the near future, but for now, NR seems to be a more predictable bet in terms of choosing between the two.
Obviously, David Sinclair has a lot of confidence in NMN as he's using the research chemical on himself, which I'm not against personally.
It all comes down to risk tolerance when using anything without sufficient human data.
The mechanism of action of both NR and NMN essentially boil down to the fact that they can significantly boost NAD+ levels in the body, which is something that the body produces significantly smaller amounts of as you age.
By supplementing with an exogenous NAD+ precursor and boosting levels up to that of a young health adult, it is theorized that one can maintain healthier cell function in the body in old age and lower the incidence of disease, degradation, and a decline in quality of life.
Personally, I use Nicotinamide Riboside (NR) because it is more cost effective right now, and it has human data to back up its efficacy and safety profile.
I take 2 servings of ResveraCel per day as of now.
ResveraCel is a NR supplement that also contains Resveratrol and Trimethylglycine (TMG).
Something less commonly spoken about is that TMG may be essential to use as a methyl donor alongside NR or NMN, depending on your genetic predisposition, in order to prevent deleterious effects from occurring.
In addition, David Sinclair takes Vitamin D-3 with vitamin K2.
First of all, I can tell you right now that contrary to popular belief, you're not going to get enough Vitamin D from the sun outside, regardless of how long you're out there.
It's very likely that you're going to need to supplement with it.
I highly advise you get a blood test to see where your vitamin D levels are at (I recommend getting a comprehensive health panel while you're at it).
Check Your Vitamin D Levels
HOW IT WORKS
1. Click “blood test” link above and it will redirect you to Private MD Labs Website
2. Select Male Athletic Anti-Aging Panel and add to cart
3. Add a Vit D, 25 Hydroxy test to it
4. Use “DC15” as a discount code for 15% off
They will email you a form that you will print out and take to the nearest Labcorp for the blood draw (the site will guide you to the nearest lab).
Then they email you the results within about 3 business days.
Vitamin D is crucial and a super cheap supplement too.
Get your blood test, see where you're at, and then create a protocol based on how much you need.
Personally, I take 8,000 IUs of Vitamin D-3 per day.
8000 IUs would be considered a mega-dose by many, but this is what it puts my blood work at:
As far as a Vitamin K2, that's something that you can get from egg yolks, butter, dark chicken meat, cheese, Natto, and a variety of other foods.
However, I do not believe that most people are hitting their requirements for Vitamin K2, and certainly not the vitamin K2 homologue MK-7.
MK-7 is thought by many to be the most beneficial Vitamin K2 homologue.
There is an abundance of information all over the web that can be overwhelming to take in.
My advice would simply be to hit the daily requirements for all of the Vitamin K homologues.
Vitamin K2 is the only vitamin that's proven to support arteriosclerosis reversal, the attenuation of further arterial calcification, and scavenging plaque in the arteries.
Vitamin K2 is responsible for getting calcium into where it's supposed to go in the body and preventing calcification in the arteries,
If you're deficient in vitamin K2, you're not going to have sufficient assimilation of that calcium into where you want it to be, and you may experience arterial calcification if your diet model supports it (most diets aren't optimized to avoid this).
I would advise a 1 soft gel of the Jarrow Formulas Vitamin K-Complex per day.
If you've seen my other articles on health supplements, you'll know that I've used this product for a while now.
It's one of the main supplements that you should religiously take, especially if you're a bodybuilder.
K2 is a more obscure vitamin that not a lot of people look at seriously, but it's one of the most important ones in my opinion.
David Sinclair also takes a Statin, which is not a supplement, it's a prescription drug for modulating lipids/cholesterol levels.
I don't advise that you haphazardly take a Statin just because David uses 0ne.
There are natural ways to improve your lipid profile, and you may not even have a poor one to begin with.
Again, this is only something that would be recommended by your doctor based on your current blood work should you have a genetic predisposition to poor lipids that cannot be corrected via diet, supplementation and lifestyle changes.
David Sinclair also takes 1 gram (1,000 mg) of Metformin per day.
He started with 500 mg per day, and then he bumped it up to one gram.
One of the main side effects of Metformin is impaired digestion, so I'm assuming that's why he started lower and titrated up to 1 gram.
Metformin is a drug that is typically given to type II diabetics to increase insulin sensitivity and control their blood sugar.
Chronically elevated blood sugar and insulin levels are thought to be one of the main causes of cancer, microbiome disturbances, and cardiovascular disease.
This all stems back to diets including crappy food and sugar, and things that spike inflammation in the body, thus causing:
- Poor digestion
- Suboptimal assimilation of nutrients
- Potentially increased levels of cancer cell growth or cancer cell proliferation
- Increased risk of cardiovascular disease
- Increased risk of plaque buildup in the arteries.
If you get your insulin sensitivity up, it will not only help lower the incidence of the aforementioned issues, it promotes a healthier body composition as well.
There are a myriad of benefits that come from being insulin sensitive.
This includes muscle growth potential.
If you're weight training and eating in a calorie surplus, you will gain a far more favorable ratio of muscle to fat if you are insulin sensitive as opposed to if you had insulin resistance.
Insulin acts as a nutrient transporter in the body, and if you have severe insulin resistance, you will assimilate nutrients very poorly and experience countless negative consequences, not only on your health, but your body composition and results in your athletic endeavors.
Getting as insulin sensitive as possible is not just conducive to health and longevity, it's also something that's going to improve how you physically look, as well as how lean or how muscular you can get.
My Conclusion On The Supplements And Drugs David Sinclair Uses
I thought David Sinclair would have some massive supplement stack.
I use more supplements than him, which surprised me.
It just goes to show what areas he feels hold the significant majority of importance.
Obviously, he has a lot of confidence in this NAD+ theory and Hormesis.
Insulin sensitivity is also greatly taken into account because he's not diabetic, but he's taking Metformin anyways.
Of the supplements and drugs mentioned, I take Resveratrol, a NAD+ precursor (NR as opposed to NMN), Vitamin K2 and Vitamin D.
Although NMN looks very interesting, I'm waiting for more clinical data to emerge on that before I incorporate it into my protocol.
Metformin is also something I've looked at personally.
I haven't incorporated it yet, but it is something I'm seriously looking at myself.
My fasting glucose levels are always spot on and I have great insulin sensitivity as is, so I have to weigh out the risk:reward of me using it.