David Sinclair Supplements For Anti-Aging - What He Takes & Why

David Sinclair Supplements For Anti-Aging – What He Takes & Why

David Sinclair is a professor of genetics at the forefront of anti-aging research.

I've taken note of his work, and as someone extremely interested in maximizing my longevity and vitality, I have incorporated a couple of his daily supplements into my own routine that I wasn't already using.

These are the supplements and drugs he uses to preserve his youth.


Science.bio Trans-Resveratrol Powder 1000mg David Sinclair's takes 500 mg of Resveratrol with yogurt upon waking up.

Resveratrol is a natural phenol produced by plants when they are under attack by pathogens, or in response to injury.

It is essentially produced as a defense mechanism, and interestingly enough, when humans ingest it, it is purported to produce a similar hormetic that activates certain longevity pathways.

The company I currently use third party tests every one one of their products, including their Resveratrol and NMN prior to selling to ensure consistent batch purity.

I have yet to see any other company selling these two products publicly post their third party test results for every single batch they put up for sale.

Science.bio Trans-Resveratrol Third Party Test Results


Nicotinamide Mononucleotide (NMN)

Science.bio Pure NMN Powder

Science.bio NMN Third Party Test Results

In addition to Resveratrol, David Sinclair takes one gram (1,000 mg) of Nicotinamide Mononucleotide (NMN) at the same time each morning with his homemade yogurt.

David takes raw NMN powder, but NMN is also available in tablet form.

A common misconception is that NMN is the same as NR (Nicotinamide Riboside), and they are often confused with one another.

The main difference between the two is the molecule size, which will likely impact how it is absorbed and assimilated.

People often get confused between the two and they'll buy NR supplements, and think that they're getting NMN, but that's often not the case.

I'm not going to say one is superior to the other because NMN has less data on it than NR.

NR is the one that has human trials to show that it boosts NAD+ a significant amount.

There's going to be more data coming on NMN in the near future, but for now, NR seems to be a more predictable bet in terms of choosing between the two.

Obviously, David Sinclair has a lot of confidence in NMN as he's using the research chemical on himself, which I'm not against personally.

It all comes down to risk tolerance when using anything without sufficient human data.

The mechanism of action of both NR and NMN essentially boil down to the fact that they can significantly boost NAD+ levels in the body, which is something that the body produces significantly smaller amounts of as you age.

By supplementing with an exogenous NAD+ precursor and boosting levels up to that of a young health adult, it is theorized that one can maintain healthier cell function in the body in old age and lower the incidence of disease, degradation, and a decline in quality of life.

Personally, I use Nicotinamide Riboside (NR) because it is more cost effective right now, and it has human data to back up its efficacy and safety profile.

I take 2 servings of ResveraCel per day as of now.


resveracel bottle (NR)

ResveraCel is a NR supplement that also contains Resveratrol and Trimethylglycine (TMG).

Something less commonly spoken about is that TMG may be essential to use as a methyl donor alongside NR or NMN, depending on your genetic predisposition, in order to prevent deleterious effects from occurring.

Vitamin D-3

Bottle of NOW Supplements, Vitamin D-3 5000 IU

In addition, David Sinclair takes Vitamin D-3 with vitamin K2.

First of all, I can tell you right now that contrary to popular belief, you're not going to get enough Vitamin D from the sun outside, regardless of how long you're out there.

It's very likely that you're going to need to supplement with it.

I strongly advise you get a blood test to see where your vitamin D levels are at (I recommend getting a comprehensive health panel while you're at it).

Check Your Vitamin D Levels

1. Click “blood test” link above and it will redirect you to Private MD Labs Website

2. Select Male Athletic Anti-Aging Panel and add to cart

3. Add a Vit D, 25 Hydroxy test to it

4. Use “DC15” as a discount code for 15% off

They will email you a form that you will print out and take to the nearest Labcorp for the blood draw (the site will guide you to the nearest lab).

Then they email you the results within about 3 business days.

Vitamin D is crucial and a super cheap supplement too.

Get your blood test, see where you're at, and then create a protocol based on how much you need.

Personally, I take 8,000 IUs of Vitamin D-3 per day.

8000 IUs would be considered a mega-dose by many, but this is what it puts my blood work at:

Derek from MorePlatesMoreDates.com Vitamin D blood test results

Vitamin K2

bottle of Jarrow Formulas Vitamin K2

As far as a Vitamin K2, that's something that you can get from egg yolks, butter, dark chicken meat, cheese, Natto, and a variety of other foods.

However, I do not believe that most people are hitting their requirements for Vitamin K2, and certainly not the vitamin K2 homologue MK-7.

MK-7 is thought by many to be the most beneficial Vitamin K2 homologue.

There is an abundance of information all over the web that can be overwhelming to take in.

My advice would simply be to hit the daily requirements for all of the Vitamin K homologues.

Vitamin K2 is the only vitamin that's proven to support arteriosclerosis reversal, the attenuation of further arterial calcification, and scavenging plaque in the arteries.

A high menaquinone intake reduces the incidence of coronary heart disease.

Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review

Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype

Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study

Vitamin K Status and Vascular Calcification: Evidence from Observational and Clinical Studies

Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5.

Vitamin K2 is responsible for getting calcium into where it's supposed to go in the body and preventing calcification in the arteries,

If you're deficient in vitamin K2, you're not going to have sufficient assimilation of that calcium into where you want it to be, and you may experience arterial calcification if your diet model supports it (most diets aren't optimized to avoid this).

I would advise a 1 soft gel of the Jarrow Formulas Vitamin K-Complex per day.

If you've seen my other articles on health supplements, you'll know that I've used this product for a while now.

It's one of the main supplements that you should religiously take, especially if you're a bodybuilder.

K2 is a more obscure vitamin that not a lot of people look at seriously, but it's one of the most important ones in my opinion.


2 stubs, 3 capsule, and a pack of Statin

David Sinclair also takes a Statin, which is not a supplement, it's a prescription drug for modulating lipids/cholesterol levels.

I don't advise that you haphazardly take a Statin just because David uses 0ne.

There are natural ways to improve your lipid profile, and you may not even have a poor one to begin with.

Again, this is only something that would be recommended by your doctor based on your current blood work should you have a genetic predisposition to poor lipids that cannot be corrected via diet, supplementation and lifestyle changes.


a pack of metformin 500mg

David Sinclair also takes 1 gram (1,000 mg) of Metformin per day.

He started with 500 mg per day, and then he bumped it up to one gram.

One of the main side effects of Metformin is impaired digestion, so I'm assuming that's why he started lower and titrated up to 1 gram.

Metformin is a drug that is typically given to type II diabetics to increase insulin sensitivity and control their blood sugar.

Chronically elevated blood sugar and insulin levels are thought to be one of the main causes of cancer, microbiome disturbances, and cardiovascular disease.

This all stems back to diets including crappy food and sugar, and things that spike inflammation in the body, thus causing:

  • Poor digestion
  • Suboptimal assimilation of nutrients
  • Potentially increased levels of cancer cell growth or cancer cell proliferation
  • Increased risk of cardiovascular disease
  • Increased risk of plaque buildup in the arteries.

If you get your insulin sensitivity up, it will not only help lower the incidence of the aforementioned issues, it promotes a healthier body composition as well.

There are a myriad of benefits that come from being insulin sensitive.

This includes muscle growth potential.

If you're weight training and eating in a calorie surplus, you will gain a far more favorable ratio of muscle to fat if you are insulin sensitive as opposed to if you had insulin resistance.

Insulin acts as a nutrient transporter in the body, and if you have severe insulin resistance, you will assimilate nutrients very poorly and experience countless negative consequences, not only on your health, but your body composition and results in your athletic endeavors.

Getting as insulin sensitive as possible is not just conducive to health and longevity, it's also something that's going to improve how you physically look, as well as how lean or how muscular you can get.

My Conclusion On The Supplements And Drugs David Sinclair Uses

I thought David Sinclair would have some massive supplement stack.

I use more supplements than him, which surprised me.

It just goes to show what areas he feels hold the significant majority of importance.

Obviously, he has a lot of confidence in this NAD+ theory and Hormesis.

Insulin sensitivity is also greatly taken into account because he's not diabetic, but he's taking Metformin anyways.

Of the supplements and drugs mentioned, I take Resveratrol, a NAD+ precursor (NR as opposed to NMN), Vitamin K2 and Vitamin D.

Although NMN looks very interesting, I'm waiting for more clinical data to emerge on that before I incorporate it into my protocol.

Metformin is also something I've looked at personally.

I haven't incorporated it yet, but it is something I'm seriously looking at myself.

My fasting glucose levels are always spot on and I have great insulin sensitivity as is, so I have to weigh out the risk:reward of me using it.

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About Derek

After dedicating over 8 years to extreme self-improvement, I have created "More Plates More Dates" as a one stop shop for helping you to get yourself on the right path to the "best you" possible too.


14 thoughts on “David Sinclair Supplements For Anti-Aging – What He Takes & Why”

  1. Love your content and your straight-forward style. Excellent info every time! I also follow Dr Sinclair, and after a bunch of research I added NMN/Resveratrol/D3/Metformin to my daily supplementation. Only been a couple of months and these are long term additions, not quick acting ones, so we’ll see. Need to add K-2.

    I think you should look into Carbon 60. Been doing research on it and it looks very promising. Just got my first batch so no results yet. Besides anti-oxidant (very strong A-O), general wellness, anti-inflammatory effects, anti-ageing, neural-protection and healing they are researching anti-cancer benefits. One maker, carbon 360, has a hair growth formula. Something for you to consider. Love to see your thoughts on C60.

    Thanks again for a great channel/blog

  2. To be honest, for a man of 50 years, he really doesn’t look all that youthful. Now if the mofo was pushing 65-70, I would be on his supplement bandwagon in a heartbeat.

    1. He’s not doing a whole lot based on his protocol. I’m looking at someone like Ben Greenfield as a better example of someone who is going no holds barred as an example of what is possible. Seems Sinclair is more focused on the research and working than taking the time to optimize his own regimen.

      1. Well, I agree, I’d rather be like Ben Greenfield than Sinclair, but to defend Sinclair I think he’s wanting to focus on longevity, not optimization.

  3. Time will tell if Sinclair develops Alzheimer’s from the statins. Also, if he is concerned with insulin sensitivity, then why not just eliminate higher glycemic index foods, i.e. sugar, grains, potatoes, corn, rice, bananas?

    1. Ya, for someone so concerned with longevity, some of his choices are questionable. Granted, you can’t always expect someone to model their research in their own lives. Anybody working around the clock probably isn’t getting optimal sleep, adequate exercise, among several other things that someone who prioritizes their own health over their research would do.

    2. David Sinclair was prescribed statin by a doctor in his twenties because of his genetic predisposition to high cholesterol. He doesn’t openly say he takes it for longevity.

  4. What about berberine instead of metformin? …seeing it’s probably hard to get if you’re not diabetic.

    My stack –

    Pure Encapsulation One Multi-Vitamin
    Thorne Magnesium Citramate
    Thorne D3/K2 Drops
    NOW Ashwaghanda w/ intermittent breaks
    NOW/Solgar B100 Compex
    Nordic Naturals Omega 3 Fish Oil
    Green Vibrance (sometimes)

    May add in Thorne’s Resveracel and berberine. Also starting sauna and getting back onto intermittent fasting again.

  5. Metformin and berberine both seem to blunt the beneficial hormetic effects from exercise… so kinda sketchy. Not enough research yet imo to take either.

    1. Your statement is not entirely accurate. It has been documented that metformin does blunt the effects of exercise, but the mechanism at which it does this is not understood. It is suspected that it does this through the AMPK pathway and mTOR inhibition, and because of that it is SPECULATED that berberine MIGHT also have a similar blunting effect.

      Lastly, the studies you are referencing acknowledge that metformin did have an effect on mitochondrial and cardiorespiratory adaptations, as well as muscular hypertrophy.

      With that said, I feel the study is a bit flawed for our use case. It was limited to adults who were 65 years or older, and the baseline metrics for the groups in the study were not balanced. The baseline numbers of the placebo group were weaker and thigh muscle measurements were much smaller.

      Matter of fact, the study even calls attention to this in the footnotes of the table that shows the 14 week outcome…. “b treatment groups were significantly different at baseline.”. Its obviously easier for a smaller and weaker person to gain more strength and lean mass from a percentage perspective, compared to a person who has more baseline strength and muscle mass to start with.

      To me, bass on the published papers available, the benefits of metformin or berberine outweigh the arbitrary negatives that were outlined in a flawed study.

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