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How Many Milligrams Of Testosterone Do Men Naturally Produce? | Comparison To TRT Dosages

How many milligrams of Testosterone do men naturally produce?

3-10 milligrams per day, with the average being 6-7 milligrams per day.

What Is A Therapeutic Dosage Of Testosterone?

When bodybuilders refer to Testosterone Replacement Therapy (TRT) dosages they’ll often state that 200 milligrams is a therapeutic dosage.

This is typically not a therapeutic dosage at all, and is more like a small supraphysiological cycle being used year round.

A therapeutic dosage of Testosterone is a dosage that would bring serum Total and Free Testosterone levels in the blood up to what you would produce naturally if you weren’t hypogonadal.

Delving into the clinical data, we can see that the true milligram equivalent is actually far less than that.

Before delving in deeper, keep in mind that ester weight and the milligram amount per milliliter stated on the vial of your prescription doesn't necessarily equate to how many milligrams of Testosterone per milliliter your product truly contains. Let me elaborate on that.

How Many Milligrams Of Testosterone Do Men Naturally Produce?

Testosterone is the principal circulating androgen.

In men, it is secreted primarily by the Leydig cells in the testes at a daily production of about 6-7 mg [R].

Other clinical data corroborates this as well.

A more broad and accurate range is 3-10 mg per day, but in general, the average daily production is approximately 6-7 mg per day in healthy men.

The difference between 3 mg per day and 10 mg per day is massive, as you would logically conclude.

However, this is not reflected in the “therapeutic” reference ranges you will see in your blood work.

The “Healthy” Testosterone Reference Range

Depending on the lab, the “healthy” range of natural Testosterone production could be as low as 240 ng/dL on the bottom, and 1000 ng/dL on the high end.

Some labs are even worse.

It doesn’t take a rocket scientist to realize that a Testosterone level 4x higher will not equate to the same quality of life, muscle building potential, etc.

However, 90% of doctors still are so far behind the curve that they truly believe that a 250 ng/dL Testosterone level is just as good as a 1000 ng/dL Testosterone level.

Weekly Testosterone Production In Milligrams

Based on the daily average production in milligrams, we can calculate that weekly the average healthy male produces between 42 to 49 mg per week.

A ton of men using 200 mg per week probably think that number is far too low and isn’t accurate.

However, what a lot of guys don't consider is that the ester itself takes up a significant portion of the milligram content per milliliter.

After administering Testosterone, your body has to cleave the ester from the molecule to free up the Testosterone to actually be bioavailable in the body, and that ester accounts for a significant portion of that milligram/milliliter amount.

The only exception to this is Testosterone Base and Testosterone Suspension, which are just straight up Testosterone products with no ester attached, but you would never get a prescription for that as the half-life is so short it would require multiple administrations per day.

Testosterone Cypionate Ester Weight

The Cypionate ester has a high molecular weight and accounts for 30% of the milligram total stated on a TRT prescription.

For example, if your TRT prescription was 200 mg of Testosterone Cypionate every week, despite the vial being labeled as 200 mg/ml, the Cypionate ester’s molecular weight takes up 30% of that mg content, and cleaving the ester from the Testosterone molecule in the body leaves only 140 mg/ml, which is 70% of the stated label dosage.

What Dosage Of Testosterone Do You Really Need For Therapeutic TRT?

There are vastly different perspectives on hormone levels in the TRT community and the bodybuilding community.

There are many men (mostly bodybuilders) who believe that 200 mg per week is the bare minimum for high-end TRT, and dosages of 250 mg or even 300 mg per week are justified as within the realm of natural production still.

There are doctors who will corroborate this too, which to me is pretty baffling.

Very, very seldom does somebody actually need 200 mg a week to maintain the equivalent of healthy endogenous production.

Usually, those guys are essentially running a cycle year-round.

This is something I’ve been saying for a while now, as I used to actually believe that 200 mg per week was therapeutic (until I started really monitoring my blood work closely).

Micro-Dosing TRT To Maintain Stable Blood Serum Concentrations

My TRT is currently 125 mg per week, and even that is pushing into supraphysiological territory when you actually split that shot into seven micro shots to keep more stable blood serum concentrations.

Splitting a large dosage/administration of 125 mg per week into 7 administrations/micro-doses of 18 mg per day increases Free Testosterone more relative to a large weekly dosage, decreases the amount of aromatization to Estrogen occurring in the body, and maintains more stable Testosterone blood serum concentrations.

Often times, doctors will prescribe their patients 100 – 200 mg of Testosterone Cypionate every 7-10 days, and then advise them to administer it in one giant dosage once per week, or even once every 2 weeks.

This is insane and reflects on how completely inept the majority of physicians are when it comes to hormone management.

When you administer yourself with a large dosage at once, you spike your Testosterone levels to supraphysiological levels, often 2x or even 3x as high as they should be for a few days, which obviously has an equivalent amount of aromatization occurring in parallel to this.

Following this, levels slowly crash down as hormone levels decline in the body, and often times patients will fall back down to the low end of the reference range while waiting for their next shot.

Spike Vs Trough TRT

The end result is a constant roller coaster of fluctuating Testosterone levels going from way too high, to way too low, over and over again, with far too much Estrogen aromatization occurring, resulting in completely unnecessary side effects.

These side effects often then need to be mitigated with an Aromatase Inhibitor, which doctors know even less about how to prescribe and mange correctly, and will often crash their patient’s E2 levels into the ground and leave them feeling like complete trash and ruining their lipids.

AI’s are not something you want to be on long term as they are not healthy, and E2 management can be done via lifestyle and diet changes more often than not in the context of therapeutic TRT.

High Dose TRT Vs Low Dose TRT

There are constant arguments about what the optimal replacement dose of Testosterone is.

There's a small camp of guys who believe that 10 milligrams of Testosterone Propionate per day is ideal for most men, and I'm inclined to agree with them far more than the guys who believe that dosages as high as 200 mg per week are necessary.

This will of course vary depending on a variety of factors, but typically 10 mg of Testosterone Propionate per day will put an individual at top end of the Testosterone therapeutic range.

I find that when men talk about ideal dosages being closer to 125 – 150 – 200 mg per week, the ester weight often isn't taken into account (Cypionate, Enanthate, Propionate, etc. all have different molecular weights), and they are often individuals who administer large dosages at once, let their levels spike way above the therapeutic limit up to supraphysiological levels for a few days, and slowly crash underneath that until their next shot.

If you get your blood drawn during a trough and the results show that you have a 850 ng/dL Testosterone level, you may not be accounting for the fact that right after you administered your fat weekly (or even bi-weekly) dosage, your levels probably skyrocketed upwards of 1500 ng/dL.

I found this statistic very interesting as 50 milligrams a week really is not much whatsoever in contrast to what most guys are injecting weekly believing they are just “replacing” their natural production.

Bodybuilders Maintaining Muscle On Only 200 mg Of Testosterone

There are a lot of massive bodybuilders, including IFBB pros, who maintain massive physiques in the off-season and in retirement with just 200 mg of Testosterone per week.

They're able to maintain physiques that are blatantly not maintainable naturally.

If top bodybuilders who are pros at 240 pounds plus are maintaining those physiques with just 200 mg per week, its pretty transparent that the 200 mg per week dosage is actually more than the therapeutic amount in most situations, and the clinical data backs this up.

Personally, I used to believe I needed 200 mg per week to maintain my physique, and I was SO wrong.

200 mg per week for most individuals is the equivalent of running a cycle year round, and certainly is not therapeutic in any capacity.

There are caveats to this, with SHBG, ester choice, body composition, diet, lifestyle factors, and many other things playing a significant role in how much Testosterone actually becomes usable in the body, consequently influencing how large of a dosage an individual would need to achieve healthy Free Testosterone levels.

But in general, true therapeutic TRT would be as simple as replicating the natural daily production of 6-7 mg with an exogenous source after factoring in the ester weight.

P.S. I do all of my daily TRT injections with an insulin pin now in my glutes and ventro glutes.

With such a low volume of daily oil, it’s something I can get away with daily without creating a lump of oil that doesn’t absorb properly, which would occur if you tried to jab a large amount of oil too shallowly with a short needle.

No more harpoons for me.

12 thoughts on “How Many Milligrams Of Testosterone Do Men Naturally Produce? | Comparison To TRT Dosages”

  1. This should be a ‘Sticky’ as sites say in there forums. Derek seems to continually present the most knowledgeable information to all of those that may be doing research papers, new to exercise, lifting with purpose of growth beyond what is naturally possible and even gives you a full amount of reasoning including his own trail and error. His own personal examples and finding played out for him (As everyone is different- what’s good for Derek may not be best for you, he’s simply guiding you through his results). Derek deserves a ton of credit for all the time and hard work he puts into everything he presents and offers to the public user. I do not know Derek personally. As Derek states these claims are made with NO intention of him misrepresenting as a DOCTOR of any sort. So please be advised to see your doctor before you decide to do anything that is stated on the site. As Derek and ‘More Plates, More Dates’ is not responsible for whomever you are nor what you do. The actions you take are found to be fully your own, at no point did Derek make a decision for you. Derek keep up the outstanding work (not only on the site but in the weight room) and may the man above watch over you, as you are kind enough to share with others! -N.E.

  2. I do a TRT dose of 250mg/week of Testosterone Enanthate (divided into two 125mg injections). My blood levels of testosterone only show a level of 530, far less than the 700 I would like to see for even a natural level. I’m 54 years old and my libido at those testosterone levels is still far below what it was at age 45 without TRT.

    1. Check your SHBG, Free T, Estradiol Sensitive Assay, DHT, and then consider a superior frequency protocol (if your doctor agrees of course).

  3. Hey Derek, ty for the input, really appreciate it. Im thinking of switching to subq daily injections now. Is a daily injection subq protocol with test cyp instead of prop an alternative?

    Also i want to know, how you manage your injections with the least efford. Do you use some insulin pen or something u can load with the oil oder do you just draw the oil from the vial with an insulin needle? Thank you in advance.

    1. Yes, the result is the same once the hormone is saturated in your system, which is stable blood serum concentrations. I put an insulin pin into the vial, draw out the dose, and then pin it in my Ventroglutes (while using sterile/safe injection practices obviously).

      1. Hi Derek,
        I’ve been doing IM every three days with a 25g /1″ for my trt.
        I’m thinking of switching to using an insulin pin and injecting more frequently.
        I’m curious, what gauge and length pin do you use? With the insulin pin going to the ventroglute, are you getting it IM or is it sub-q? Do you ever pin the deltoids with your method?
        Btw, I love your youtube channel. Thanks 🙂

        1. I just use the standard 8 mm (5/16″) insulin pins my local pharmacy sells. It’s shallow enough to stay subq jabbing straight in at a 90 degree angle in ventro glutes.

  4. Derek you believe going intramuscular in the glute with insulin pin is better than subq in the stomach? Im doing 50mg on monday and 50mg on thursday subq with insulin pin in stomach. What size pin you use in glute? Thanks

    1. I don’t think it’s better necessarily, this is just how I prefer to administer it.

      I don’t pin glutes either, I pin my Ventroglutes specifically.

  5. Do you think 18mg per day cypionate is a good starting point if you have an shbg of 35? Never feel consistent on twice weekly trt protocols.

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