LGD-3303 SARM Overview – What To Expect + LGD-4033 Comparisons

LGD-3303 is purported to be one of the best SARMs out of all for overall sheer mass and strength gains.

It is relatively new on the scene, so there are very few logs out there detailing personal experiences with this SARM; hence much of the information we gather about this compound has to be confirmed via future testing and personal research.

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What Is LGD-3303?

LGD-3303 is a selective androgen receptor modulator (SARM) developed to prevent muscle wasting, treat Osteoporosis, greatly enhance lean muscle growth potential and help older individuals maintain strength and lean tissue.

It is non-steroidal, and is ingested orally. It binds to the androgen receptor with an extremely high affinity and selectivity, and once it does this it exerts exceptional anabolic effects in muscle and bone, equating to a large increase in muscle size and strength.

As far as how androgenic LGD-3303 is, it is a full agonist on muscle and a partial agonist on the prostate.

Referring to the graph above, you can observe the dose dependent response on prostate size that LGD-3303 induced, with which we can assert how androgenic this SARM really is.

As you can see, at the 1 mg/kg/day dosage (the dosage roughly equivalent to the standard starting daily dosage for research in humans) the effect on prostate weight (proposed androgenic activity) was minimal relative to what prostate weight was when the research subject wasn’t using LGD-3303 at all.

With this statistic, we can assume that the androgenic effects in the body are minimal at the effective dosage for muscle building purposes, thus making it a very promising SARM.

LGD-3303 shares a very similar chemical structure to LGD-4033, which is a far more “mainstream” and popular SARM, notorious for its’ fantastic mass building properties relative to the other most commonly used SARMs.

What Can You Expect From LGD-3303?

LGD-3303 is going to be up there at the top of the list with the other most potent SARMs in terms of size and strength gains.

LGD-3303 is known for providing a noticeable muscular fullness despite being a dry compound.

Whether this fullness is achieved via greatly increased nitrogen retention or its’ nutrient partitioning effects, that is unknown, but typically dry compounds don’t give the muscle that “pop” that wetter compounds can due to the intramuscular water retention they provide.

This is one way that LGD-3303 shines, as it can give a very apparent quick boost in size, followed by an appreciable amount of dry mass gains in the weeks to follow without the blurring muscle definition at all.

The strength gains from LGD-3303 are very respectable as well.

What you can expect from LGD-3303 is a fairly substantial boost in lean, dry mass gains, with a considerable increase in strength and muscular endurance.

How To Dose LGD-3303?

The half life of LGD-3303 is about 6 hours.

LGD-3303 Pharmacokinetics

Referring to the bottom graph above, you can see the plasma serum concentration of LGD-3303 peaking at ~0.08 μg/mL, and then reaching ~0.04 μg/mL at roughly 6 hours. It then drops to ~0.02 μg/mL about 12 hours after dosing.

Considering this short half life, dosing for LGD-3303 should be more frequent to maintain stable blood serum concentrations throughout the day.

Dosing LGD-3303 3 times per day (in the morning, midday, and again at night) would be ideal to maintain stable serum concentrations.

In the clinical studies, a dose of 1 mg per kilogram (research subjects’ body weight) was a sufficient dose to completely replace the anabolic support provided by natural testosterone production in terms of muscle growth.

This would equate to a dosage of roughly 11 mg in humans.

The consensus on LGD-3303 typically is that substantial results can be expected at doses of about 10mg or higher, and the sweet spot may be closer to the 20mg range.

High levels of suppression are expected even on “moderate” dosages of LGD-3303, and most individuals have reported better results from dosages closer to the 20mg side of the spectrum.

It doesn’t matter if the research subject is on an empty stomach or not during the administration of LGD-3303.

Do I Need To Do A PCT After A LGD-3303 Cycle? Are There Side Effects To Worry About?

LGD-3303 is very suppressive, so symptoms of Testosterone suppression (if you are prone to them) are possible on cycle.

Keep in mind, this is an individually dependent thing, as some individuals actually note an increased libido while being borderline shutdown on certain SARMs, and this is because the SARM is replacing that physiological function in the body in the absence of adequate Testosterone production.

One study actually suggests that LGD-3303 in particular exerts a blatant prosexual effect, meaning it can actually increase libido above baseline (what the sex drive was pre-cycle).

As you will be borderline shutdown (or fully shutdown) on LGD-3303, a full PCT is absolutely necessary post-cycle.

As of now, there aren’t many anecdotal logs or clinical studies to draw from in terms of assessing other potential side effects, so aside from the standard SARM related side effects (endocrine suppression, possibility of high Estrogen side effects, etc.) there are no side effects we are aware of that are entirely unique to LGD-3303.

Do I Need To Use An Aromatase Inhibitor With LGD-3303?

As SARMs bind very tightly to the androgen receptor, this can create a scenario where Testosterone may be diverted more towards DHT and Estrogen conversion, as there are less vacant androgen receptors for it to attach to.

The net result of this could be an increase in Estrogen levels; hence why there are certain cases of individuals experiencing gyno and other Estrogen related symptoms cropping up on SARM only cycles.

However, this is easily controllable by taking 25-75mg of Arimistane each day during your LGD-3303 cycle (the dose you need will depend on your individual propensity to aromatization).

I suggest starting at 25mg.

Arimistane is a potent aromatase inhibitor, which will mitigate potential gyno flare-ups and other high Estrogen related issues by keeping your Estrogen levels in the sweet spot where it’s not too high and not too low (I feel that this Estrogen sweet spot is between 20-30 pg/mL for most men).

What Scenario Is Best To Use LGD-3303 In? Bulking/Cutting/Recomposition?

LGD-3303 works in EVERY scenario as it has an unrivalled ability to build mass relative to other SARMs in a calorie surplus (aside from maybe S23 and LGD-4033), as well as retain lean tissue in a calorie deficit.

As it is extremely versatile, it can be utilized in a cut, bulk, or a recomposition phase with great success.

LGD-4033 Vs LGD-3303

As far as a mg:mg comparison, it is tough to say whether or not LGD-3303 is any more potent than LGD-4033 at the moment, despite many individuals assuming that LGD-3303 is more potent.

This may not be the case though, as most LGD-3303 logs either utilize an equivalent dosage as the standard LGD-4033 cycle, or actually use a higher dosage of LGD-3303 pushing upwards of 20 mg per day.

Unlike LGD-4033, LGD-3303 is typically regarded as a dry compound; hence there is a far greater likelihood that it will not blur muscle definition in a cut phase.

The reason dry compounds are ideal in a cut phase is that once you have stripped off your excess fat, compounds that have a tendency to retain subcutaneous water can hide your muscle definition, which is the opposite of what we are trying to accomplish during a cut phase.

LGD-3303 is not only strong enough to retain your hard earned muscle in a calorie deficit, but it will not hinder the cosmetic appearance of your physique in any way as it will not cause water retention.

This makes it a potentially ideal cutting compound.

It could be argued that in a bulk phase that LGD-4033 may be a better alternative as it may provide beneficial joint fluid that will decrease the risk of injury as strength levels climb, but which is the ideal choice will ultimately be determined by the researcher.

In the context of a bulk phase, if one is willing to deal with total shutdown vs suppression, and if one would like to avoid water retention during their mass gaining phase or not are two of the main factors that should be considered when deciding between which compound would be best in that researcher’s protocol.

Where To Buy LGD-3303

These Are My Current Trusted/Go To Companies For Third Party Tested SARMs:

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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21 thoughts on “LGD-3303 SARM Overview – What To Expect + LGD-4033 Comparisons”

  1. Quick question for clarification.

    You mentioned LGD-3303 12mg per day total split up into 3 doses per day, once upon waking, once mid-day, and once before going to bed.

    When you say split up, does that mean 12mg split up to three 4mg doses per day or take three 12mg doses, three times a day?

    The same with the RAD-140, take 20-30mg twice a day or take 10-15mg twice a day.

    Thank you,

    1. Sorry I meant to say

      “When you say split up, does that mean 12mg split up to three 4mg doses per day or take one 12mg dose, three times a day?”

      1. There is no set in stone way to do this, for LGD-3303 you ideally want to split the dose up as many times per day as possible to maintain stable serum concentrations. For RAD-140 the half-life is longer and can be dosed twice per day to ensure stable serum concentrations, but it’s not like you can’t split that up into 3 doses if your research caps are 10mg for example.

        If I were dosing LGD-3303 at 12mg per day with 3mg caps for example, I could split that into 4 doses per day, or I’d just double up on the pre-workout dose probably and keep it at 3 doses per day. As long as the dose is spread out enough is the main concern where you aren’t utilizing a bolus dose once per day where levels will spike sharply and then completely fall off before the next dosage.

  2. Hey Derek,

    Didn’t the libido increase shown in studies specifically apply to females only? I can’t seem to find any studies that note an increase for the male counterpart. Also, I was planning on including this in an upcoming cycle with the minimal effective dosage to make a max effort at limiting the suppression sides as much as possible. Do you think a 6mg, 2-day split of 3mg in the morning 3mg in the evening would be optimal even with its 6 hour half life? Thanks a bunch for your response in advance.

    1. The study was done on females only, however, the same mechanism of action leads to an increase in libido in males as it does females in many aspects, and the study referenced how “testosterone patches increase libido”, which they also do in males obviously. By finding a potential therapeutic for women with sexual desire disorders, we can also surmise that the same benefits would also be present in males, the study just so happened to be female specific. For dosage splitting, I’d split it into 3 doses ideally. However, if that is overly inconvenient (or you are using a dose that is too low to split into 3 doses), my educated guess is that splitting it into 2 dosages in the morning and at night would be negligibly less effective at most, and would likely be just fine.

  3. Good write up Derek. I had great results with LGD 4033 and I don’t hold water on it. Looking forward to trying 3303. I hope to see more logs as well.

  4. Hey Derek,

    I have read the majority of your posts and watched your videos. I followed your plan for first time SARM users (LGD-4033 and MK-677) for 12weeks and am about to my PCT for a month. I am planning out my next stack and would like to add more compounds, I am having a hard time deciding what would be best for muscle gains with all the new SARMS coming out. I plan to stay with the LGD-4033 and MK-677 and add on YK-11 but would be another good SARM to add on for muscle size? S23? One of the new ones? Also would I need a test base on a cycle like that? I plan to get on TRT in the future but right now am not able too. I am around 11% BF and have my nutrition and training in a good place. Any advice is really appreciated. Thank you so much!

    1. Stay away from things that will fully shut you down if you can’t use a test base ideally. I’d just add in RAD-140 on top of LGD-4033 and MK-677 if it were me. Or MK-677 + Ostarine + RAD-140 would be solid.

      1. Should I stay away from YK-11 due to the suppression? Is there a test base you’d recommend other than TRT? I will plan to get on RAD-140.

        Thanks Derek!

          1. Not really comparable. One is a SARM and one is a DHT derivative and Myostatin Inhibitor. 3303 is more anabolic, YK-11 is more androgenic.

  5. i keep hearing people on other forums that lgd 4033 and rad fight for the same receptor. Is this true?? iv taken both together many times and have great results

  6. Pingback: Everything You Should Know About LGD-3303 (VK5211, Anabolicum) SARMs in 2021 - Herculean Strength

  7. Pingback: SARMs in 2022: Everything You Should Know; How to Buy - Herculean Strength

  8. Hi Derek,

    Female, 58, breast cancer survivor (ER/PR+, Her2-), recently diagnosed with osteoporosis, likely due to arimidex for estrogen suppression combined with a few cycles of cardarine (cardarine did not work great for me). I have taken Winstrol and had great results, however the hair loss and body hair are becoming problematic. Lipids and liver values are great and I take liver protectants. The lack of aromatization and dry gains were the attraction. Now considering RAD140 and possibly LGD3303. Looking for gains, bone mass increase, little to no aromatization and something easy on my hair (I do take oral minoxidil 2.5mg/day for hair loss). The reported increase in sex drive with LGD3303, is a big interest for me, since menopause + AI therapy has left me with less than no sex drive and so dry that sex is extremely painful and difficult, even with HA lubes… ALSO, I have picked up a bit of fat lately, going from about 14-16% to 20-21% (I had a double mastectomy without reconstruction, so should carry less than a normal female). I would like to hold steady at about 12%. I want to stay away from compounds like T3 and insulin, cardarine didn’t help much and I am pretty sure tanked my bone density. I do take Vyvanse for binge eating disorder, but am looking for something like DNP, have heard there are some brand new compounds that act min the same way as DNP, but aren’t as dangerous for risk of hyperthermia. Any thoughts? What do you suggest for joint pain in aging…peptides, nootropics etc. hat may be of benefit?

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