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LGD-4033 Vs Ostarine – Which SARM Is Better And Why?

LGD-4033 Vs Ostarine

LGD-4033 vs Ostarine is the most common comparison you will see between SARMs.

Both Ligandrol (LGD-4033) and MK-2866 (Ostarine) have gained a lot of popularity over the last half decade in the bodybuilding community as fantastic muscle building agents.

The question on everybody’s mind is, which is better?

I’m going to break it down for you, as it isn’t as cut and dry as one is outright better than the other.

Size And Strength Gains/Bulking

LGD-4033 has an unmatched ability to build muscle mass relative to other SARMs.

Milligram for milligram, it even outperforms many of the most potent anabolic androgenic steroids.

LGD-4033 Vs Ostarine Increase In Muscle Mass
LGD-4033 Vs Ostarine (VK5211 Vs Enobosarm) Vs Nandrolone (Deca)

While some SARMs come close like S23, LGD-4033 shines in its ability to pack on size and strength.

Ostarine is effective as well, but LGD-4033 is the tip of the iceberg when it comes to gains in muscle mass per milligram as of now.

LGD-4033 is reported to be “watery” by several individuals.

By that, they mean it has a propensity to cause some water retention.

I have never seen that myself personally, and I believe it is more likely a diet and body composition issue being compounded by Ligandrol's mechanism of action in the body in some capacity, rather than the SARM inherently bloating people up.

For example, a completely garbage diet on Anadrol will bloat you like crazy, but if your diet is in check, you're lean, and you're not overeating, you will not bloat whatsoever.

Anadrol is commonly used by bodybuilders pre-contest all the way up to the day of their competition because it simply will not bloat you if you're in shape.

Instead, it will just help you hold intramuscular fullness and maintain a severely elevated red blood cell count (extremely unhealthy, but helpful for the stage nonetheless).

With that being said, if water retention is exacerbated by diet choices in a calorie surplus, then it may artificially inflate the perceived benefits of LGD-4033, sort of like Dianabol.

Based on personal experience, I can say that it is still superior to Ostarine at building muscle, even when factoring this possibility in, and there is a significant amount of clinical data to back this up as well.

When it comes to strength gains, the difference between Ostarine and LGD-4033 is not as staggering as the difference between their gains in muscle size, however, LGD-4033 still edges it out in that category as well.

For Cutting

Muscle preservation is the goal while cutting, not building muscle and strength.

The anabolic demands of a cut phase are lower during a phase of muscle preservation than during a phase of trying to gain supraphyisological amounts of muscle tissue.

The only purpose “cutting” compounds truly serve is to create a certain cosmetic look on stage.

Muscle preservation can be accomplished fairly easily with an array of different compounds with equivalent levels of success, the only thing that makes one cut phase yield different body composition outcomes than another are the androgens used in the weeks leading up to the competition that can dry out the muscle, or provide a granite look that otherwise wouldn't have been achievable at that same body fat percentage.

This is less relevant to our comparison of LGD-4033 vs Ostarine, but it's a good way to exemplify how at the end of the day both will prove sufficient anabolic aids for retaining muscle tissue and strength in a calorie deficit.

One reason that Ostarine is often preferred during a cutting phase is the perceived lack of water retention relative to LGD-4033.

Again, neither compound will bloat a lean physique in a strict deficit with a clean diet.

However, some users report a dryer, harder look from Ostarine.

In addition, calorie restriction and getting extremely lean will inevitably lower natural Testosterone levels.

It's an unavoidable outcome that natural bodybuilders have to endure.

While SARMs will help prevent catabolism during this calorie restricted phase of suppressed Testosterone production, the SARMs further exacerbate Testosterone suppression by suppressing luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis [R].


This is where Ostarine can arguably edge out LGD-4033, as it is significantly less suppressive.

While muscle loss could be staved off with the use of either SARM, the likelihood of low-Testosterone related sexual dysfunction and other androgen deficiency related side effects are less likely to occur with Ostarine.

Both SARMs exhibit blatant endocrine suppression in a dose-dependent manner, LGD-4033 milligram to milligram is far more suppressive than Ostarine though, and low-Testosterone related side effects are reported more often from Ligandrol users.

Consequently, it is absolutely IMPERATIVE that you complete a PCT (post-cycle therapy) after your Ostarine, LGD-4033, or SARMs cycle in general finishes.

This means literally the day after your last Ostarine or LGD-4033 dose, you begin your PCT.

If you don’t screw this up, you will likely encounter no issues and should recover in a very timely manner.

I don't endorse the use of either compound, but if you're going to be using them anyways you should be aware of their very real side effects.

Do not use performance enhancing compounds at all if you haven't done sufficient research prior to starting them with a complete concrete game plan of how you are going to address and mitigate potential health implications should they arise.

Both SARMs will cause some degree of Testosterone suppression at the dosages commonly used for bodybuilding purposes.

In Conclusion

Ostarine and LGD-4033 both have their place and serve a very useful purpose.

By researching and understanding how they work in contrast to one another, their potential side effects and their efficacy profiles, you can make a more informed decision about what you feel is ideal for your individual specific goals.

These Are My Current Trusted/Go To Companies For Third Party Tested SARMs:

Science.bio – 10% off coupon code “DC10”

Chemyo – 10% off coupon code “DC10”

Amino Asylum – 20% off coupon code “DC20”

Swiss Chems – 25% off coupon code “DC25”

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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47 thoughts on “LGD-4033 Vs Ostarine – Which SARM Is Better And Why?”

  1. Hello,

    Thank you for your input on SARMS, I’ve read some of your stuff on the GLL forumn.

    Quick Question – other then PEDs (if you choose to take em, I’m all for em), what supps do you REALLY need, man?

    It’s so hard to search your way through the online bullshit advice of people trying to sell ya shit. I take a Opt-Men Multi, Zinc, Vitamin D and B and that’s it. Any input.

    – thank you.

  2. Is there any data on hair loss with SARMS

    I mean , they supposed to be selective but I’m not sure if it wont attack hairline if I’m prone to MPB

    Your opinion?

  3. Hello Derek,

    Thank you for all your hard work. I have been binge reading your blog for 2 days. My questions is about the PCT and an Ostarine cycle. In your older articles you mention taking pct starting in week one and this article you suggest starting the pct on the last day of an Ostarine cycle. I have not taken any supplements other then the regular staples as an all natural athlete. I am going to try a sarms cycle for the first time (Ostarine + MK677) I got from Neoboics. Is there a PCT you recommend that I can get in Canada? what doses would you suggest for a newbie. I am a lean 6’1 185lb male.

    1. I never said start PCT during week one. I said you can take Arimistane at a low dose each day to offset suppression symptoms, but no, that is not the same thing as PCT.

      Arimistane can be used in a low dose to offset suppression symptoms mid-cycle, but also at a higher dose for PCT after your Ostarine cycle to boost your T levels back up.

      You can order Arimistane to Canada, it is legal and OTC. Arimi-RX from EA is a good one. Use discount code DC15 to save 15% on it. It is mild, but is typically sufficient for a cycle where the only suppressive compound is Ostarine.

      1. Thanks DEREK. How would you suggest I take these items. I have a bottle of mk677 90 caps 15 mg and mk2866 90 caps at 25mg. Huperzine a 200 mcg 120 tablets. And based on you recommendation I will be get the ARI I-rx 120 tabs at 25 mg. thanks.

        1. I have articles on both of those compounds with the recommended dosages for research purposes in them.

          Check them out and then let me know if you have any questions brother.

          1. Ok all set. I do have a question. I herd some guys are opening the capsule because they can’t swollow them and the taste was terrible. I open mine and it had no taste. Is that a good or bad thing. I bought from one of your suggested retailers.

          2. If you got it from where I recommended then it’s good to go. Taste means nothing, different companies use different fillers.

  4. I found your article very informative as I am deciding on Ostarine or LGD (first time user of anything to build more muscle mass and actually recomp). My only concern is there is rarely any information regarding PCT and females after SARMS. I’m sure it is necessary for women as well.


    1. Ostarine is more mild and is typically a better choice for females. I have many female friends who have used Ostarine with great success.

  5. You’re a great source of information Derek. Many thanks for the great articles.

    It would be really cool if you did a MK2866/LGD4033/RAD140 comparison with pros and cons and so on.

    Which of the three would be best for mass and strength? And for cutting?

    Does one of these have a distinct advantage in athletic performance/endurance in high intensity training?

    Thanks again!

    1. I’ve already done similar articles/videos brother. LGD-4033 is best for overall mass and strength, RAD140 is a close second though.

      For cutting I’d prefer Ostarine if I had to choose 1 of the 3.

      Yes they all will help increase athletic performance/muscular endurance to an extent, but I’d say RAD140 is probably the best SARM for that specifically as it’s ability to increase endurance and speed is the strongest of all SARMs. For cardiovascular endurance, Cardarine is by far the best, but it isn’t technically a SARM.

      1. Hi Derek

        How much more powerful would you say RAD-140 is in comparison to Ostarine in terms of improving Athletic performance. I have ran a cycle of RAD-140 at 30mg and The increase in anger was unbelievable and it is putting me off of wanting to reuse it. Any idea’s for what I could do instead?

        1. Not a ton. They are both great man, if you don’t like the emotional side effect from RAD140, you would definitely benefit from trying Ostarine or LGD-4033 instead.

  6. Hey Derek,

    Thanks for the article! I`m currently on 500mg of test + 500mg equipoise/week, bulking. Would LGD-4033 be a good addition to this stack?

      1. I appreciate the help!

        Based on your response, I assume that there is no need to add any SARMs the stack?

        I`m 205lbs, staying within 13% BF range, gained a little over 16lbs since beginning of cycle (currently 5 weeks in). Mass gain slowed down substantially, so I was considering either increasing calorie intake or trying SARMs (already ordered MK-677).

        1. I’d add MK-677 to that if anything. Or a solid dose of YK-11 maybe. You don’t need any SARMs added to that.

  7. I know it been mentioned that LGD and Ostarine you take in the AM because of the half life.
    Would it make a difference if one works out in the evening. In such case taking the dose closer to that point rather than first thing 12 hours removed from the workout?
    Just trying to see if it would make a difference for maximizing the drug effectiveness.


  8. Hey there. Just a couple questions: Will SARMS show up in a drug test for a job? This is just a basic blue collar job not something like FBI. Also does TSA from the airlines confiscate SARMS? Thanks.

    1. 99.9% of normal jobs wouldn’t test for SARMs, or even AAS for that matter.

      TSA depends on who you’re dealing with I would guess.

  9. Great articles dude, lots of great information.
    Anyways, I’ve been taking 7.5mg /day LGD-4033 ( size of one pill) and 20 mg /day MK-677 for about one month with good results. My question is increasing the dose from 1 pill to 2 pills of LGD-4033 meaning a daily dose of 15mg, if that is a recommended dose, and is there anything to be concerned about with that amount of the product. Currently not taking any pct type product either.
    Thanks in advance

  10. Hey Derek, I forgot to take my ostarine dose this morning, do I wait to take until tomorrow morning or do I take it today and then keep same dosage time going forward? Like if I have been tking at like 9 am and cant take it until 3pm today, do I take a 3 pm tomorrow going forward? Ive been on for about 25 days at 30 mg. Thanks

    1. You’re overthinking things. It has a 24 hour half-life. If you forget, then administer it when you remember and jump back on your normal schedule the next day.

  11. Hey Derek,
    I plan to start my first sarm cycle.
    Would you take 5mg LGD or 25mg ostarine?
    I dont want to start too harsh right away.

  12. Hi Derek. Which sarms has given you best gains. And which oral aas has given you best gains. And how would you compare them. We know sarms are great but will steriods always be stronger.

  13. Hey Derek what’s the max LGD week protocol you’ve seen where it’s actually productive to sustaining long term gains is it 8 or 12 weeks

  14. Hi, is it prudent to stack both of them? one pill a day? does it make a difference? or is it just a waste of money? do they used the same receptors?

    1. I’d stick with one or the other if you are new to SARMs. If you want to know about hypothetical dosages, and everything you’d need to know about them, read my respective articles on them in the SARMs section. Yes they both occupy Androgen Receptors. That doesn’t mean that they use them all up though and won’t work when one another are present.

    1. You would be more suppressed. If it’s too much or not should be based on your goals and if you are willing to deal with extra suppression.

  15. Hey Derek, i wanna use LGD right now but i have some questions to you and i hope you can hjelp me here. When i start with lgd. Should i take other things or only lgd? I have lgd and lgd stacked with ostarine? What about suppression of lgd?

    1. All your questions are answered in my other articles already brother. The AI’s and PCT one is linked in the article right here.

  16. Thanks for the great site Derek. Is it possible that the difference in LBM gains between Ostarine and LGD is simply due to dose? (Is Ostarine underdosed?)

  17. Hi Derek, super quick just wanted your opinion on Aromasin as PCT for an 8 week cycle of ostarine, thanks in advance
    Chris Tummino

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