MK-2866 (Ostarine) Frequently Asked Questions
How to dose MK-2866?
Keep in mind, the clinical studies assessing MK-2866 were only using a few milligrams, and it proved effective at that dosage. As of recent, phase II clinical trial results were released with women tolerating dosages as high as 18 mg per day.
Typically, the consensus in the community is that a 25 mg dose per day for men and a 10-12.5 mg dose per day for women is the sweet spot for minimizing potential side effects, and maximizing user benefit. However, I believe that those numbers are somewhat arbitrary and should be further investigated before assuming those are the ideal dosages for the highest ROI.
Does MK-2866 need a PCT afterwards?
Yes, if someone has suppressed their endocrine system in any capacity (even a mild amount), a PCT would be very wise. I consider it mandatory myself.
Will MK-2866 affect fertility?
No, it won’t. It is AT WORST, moderately suppressive, and this is very temporary (unless you don't PCT properly then recovery will take longer).
Fertility won't be permanently compromised from MK-2866 usage.
Can MK-2866 be used year round?
No, it is much wiser to cycle Ostarine.
While someone could very likely get away with cycles longer than 8, 10, even 12 weeks side effect free, the 8 week mark is usually where diminishing returns start to present themselves anyways, and the chance of side effects increases.
How long should an MK-2866 cycle be?
How long a cycle should be is dependent on several individually dependent factors, however, in general a standard MK-2866 cycle is typically about 8 weeks, following which PCT would be started immediately for 4 weeks.
How much time off should be taken after an MK-2866 cycle?
After PCT, the amount of time that should be taken off before starting up another cycle of another suppressive anabolic compound should be dictated by a variety of factors and will vary person to person.
A general rule of thumb that is promoted by many in the community is time on = time off, however, I do not believe in that whatsoever and I think it makes far more sense to wait until a PCT phase is concluded, and then make an assessment based on your blood work and state of health at the time.
If full recovery of the endocrine system has been achieved and blood work, organ function, etc. are all spot on, I don't really see the necessity for time on = time off.
On the other side of the spectrum, if you have a guy who's state of health is abysmal, then his time off should be equivalent to however long it takes for him to reach optimal health again.
If that never happens, then he probably shouldn't be taking anabolics in the first place.
What supplements should be taken with Arimistane to help with recovery?
It’s not 100% necessary, but it certainly will help boost your testosterone, which in conjunction with the Arimistane is a very good combo for getting yourself back to 100% as quick as possible and maintaining all progress made.
Does MK-2866 cause testicle shrinkage?
As MK-2866 has shown to be mildly suppressive in some cases among individuals, it has the potential to shrink the testicles a little bit while it is in the system.
However, they should very quickly return to full size after the MK-2866 cycle and PCT following that is completed.
Is it advised to take Arimistane alongside the MK-2866 or wait until after coming off of MK-2866 to start it?
PCT is started immediately the day after a cycle is completed, not simultaneously during the cycle itself.
However, if high Estrogen side effects crop up mid-cycle (ideally determined through blood work, but there are a variety of high estrogen side effects that are fairly obvious just from observation) then it is advised to start utilizing an Aromatase Inhibitor immediately alongside the MK-2866 during the cycle until Estrogen levels are brought back into range (the ideal range is about 20-30 pg/mL in my experience) and to maintain them in the Estrogen sweet spot for the remaining duration of the cycle.
The Aromatase Inhibitor used should reflect how much aromatization is occurring in the body. Hence why using something powerful like Arimidex or Letrozole during a SARMs only cycle where SARMs do not aromatize into Estrogen at all would be a horrible idea and result in tanked Estrogen levels.
Arimistane is ideal and sufficient for most, but Aromasin may be necessary for a small minority of individuals who genetically already had high Estrogen levels pre-cycle, were borderline, or just genetically respond to SARMs by diverting a greater amount of natural Testosterone into Estrogen via abnormally high aromatization levels.
Can women use MK-2866?
Yes. While it is true that some women are willing to accept the masculinizing side effects of anabolic steroids, most women want to maintain their femininity.
MK-2866 really shines here, as it is not 17 alpha-alkylated and is minimally androgenic, while still being able to deliver significant anabolic gains in lean muscle tissue.
Dosages as high as 18 mg have been shown in phase II trials to be generally well tolerated by women for up to 12 months (the duration of the trial) [R].
Will MK-2866 affect a woman's period?
Using MK-2866 in females may result in missed periods, however, it would resume as normal after discontinuing MK-2866 use.
Can MK-2866 be used just pre-workout for a little boost?
As blood plasma serum levels need to build up with MK-2866 use for it to do its job, taking it only on training days for temporary boosts in muscle gain or strength wouldn't be optimal.
For MK-2866 to work optimally, it has to be taken everyday as scheduled to allow the drug to build itself up over each day of consecutive use and fully saturate itself in order to produce the full benefits it can provide.
Not to mention that continuous hormonal fluctuations by having hormones going up and down constantly would yield several side-effects that otherwise would likely not be present (e.g. acne outbreaks are greatly exacerbated by hormonal fluctuations, hence why most people break out the worst during PCT when they aren't even using any anabolics).
I’ve heard MK-2866 can help with shin splints, is that true?
MK-2866 has been shown to increase tendon strength, improve ligament health, increase bone density and increases the rate at which collagen is turned over.
Consequently, previously nagging injuries may have their healing processes expedited while on MK-2866.
Could MK-2866 be used to aid in recovery from surgery?
That is likely one of the main uses it will have once/if it gets approved in the medical community.
MK-2866 may be effective for treating injuries post-operation to help maintain muscle and speed up the recovery of the bone or tendon that has been operated on.
Can MK-2866 be used for bulking and cutting? Or only for cutting to maintain muscle?
In a calorie deficit MK-2866 will retain MUCH more lean muscle mass than one would otherwise be able to naturally, and in a calorie excess (bulk) MK-2866 will promote more lean muscle gains than one would gain under normal circumstances
I've heard that MK-2866 liquid is more potent than capsules or pills, is that true?
No, that is a complete myth.
MK-2866 will be 100% bioavailable regardless if it is in a capsule or in liquid form.
What's the highest safe MK-2866 dosage?
For men, a dosage of 25-30 mg is widely considered to be a ceiling where increases in dosage past that point would start exhibiting diminishing returns and a much higher likelihood of side effects.
With that being said, that dosage is derived by speculation and broscience, so what dosage is “too high” has yet to be established.
What we do know is that MK-2866 will have dose dependent increases in muscle mass, but also dose dependent testosterone suppression, among all of the other side effects associated with MK-2866 that increase in a dose dependent manner as well.
GTx claims that in their clinical trials, dosages as high as 100 mg per day were still generally safe and well tolerated so take from that what you will [R].
What kind of diet is best to follow on MK-2866?
That is completely dependent on goals, and that question doesn't even need to be answered in the context of “on MK-2866” as my suggestion would be the same regardless.
If you are carb-sensitive for example (one of many) and trying to lose body fat, then you would likely be better off with a high protein, medium fat, low carb diet operating at a calorie deficit.
It would take me hours to outline every type of diet you could follow in specific situations, but I suggest that you either do a dedicated bulk, or a dedicated cut to get the greatest level of benefit possible out of what you're doing.
Body recomposition cycles can be utilized with great success still, but in the grand scheme of things it is more beneficial to your long term physique progression to stick to one concrete goal.
Lose fat and preserve muscle, or gain muscle and keep fat gains to a minimum.
Can I be a bit more lax on my diet if I use Osta?
Theoretically, yes to some extent because it will allow you to burn more fat and gain more muscle than you normally would.
HOWEVER, you shouldn’t be using a compound like this if you are just looking for an excuse to be lazy.
Following a strict diet and training regimen is always recommended regardless of what you are/aren't using to produce huge changes in your body composition that would otherwise be impossible on a crappy diet.
I can barely understand what the active ingredients are in the Arimistane, can you put it in simpler terms for me so I understand?
The main ingredient that you need to look at in regards to Arimistane is Androst 3, 5-diene-7, 17-dione (ADD/Arimistane).
Just like the drug Exemestane (Aromasin), Arimistane is actually a suicide aromatase inhibitor (AI), meaning it will permanently bind to the Aromatase enzyme and prevent any estrogen rebound. Arimistane reduces cortisol levels, raises Luteinizing hormone (LH) and increases the body’s testosterone levels.
Arimistane not only inhibits estrogen, it also prevents this hormone from rebounding after cycle.
This is important to have for a cycle because if estrogen side effects occurred, then you would be ready to combat them right away with Arimistane for the remaining duration of your cycle.
It will also be very effective as PCT if used for mild cycles of minimally suppressive compound(s).
If you were to compare MK-2866 gains to a certain steroid, what would it be?
As MK-2866 gains are dry, lean, but not insanely dramatic, I would equate MK-2866 results to a mild dose of Turinabol, Primobolan, or even a bit of Anavar.
Those are the first steroids that come to mind when I think of drugs that deliver the same kind of results as MK-2866.
I am on Accutane right now for very bad cystic acne and I can’t run gear with it. Could I use MK-2866 during my accutane cycle safely?
MK-2866 is not 17 alpha-alkylated (unlike oral anabolic androgenic steroids), so it is generally regarded to not be Liver toxic.
However, in some of the MK-2866 clinical trials, increases in ALT levels were noted at dosages as low as 3 mg per day, so it would be safer to assume that there is some potential liver toxicity, especially at the dosages commonly used by recreational users that are using it for performance enhancement [R].
MK-2866 vs MK-677, which would give better results?
MK-2866 works off of the body’s androgen receptors while MK-677 stimulates GH pulses so the comparison is essentially apples to oranges.
This is like the equivalent of asking which drug is better Testosterone or GH…
One would be used for the anabolic properties of the compound (MK-2866 for muscle gain/retention and strength), while the other would be used for body composition benefits and promoting cellular hyperplasia.
Can MK-2866 cause gyno?
In almost every single case, no, however, signs of oncoming gyno could present themsleves if you genetically aromatize more Testosterone to Estrogen than normal.
When MK-2866 occupies the androgen receptors, more Testosterone is diverted to aromatize into Estrogen as it has less receptor sites to bind.
Much like how Finasteride can cause gyno by preventing Testosterone from converting in to DHT, MK-2866 can have a similar outcome where there are less vacant receptor sites, thus more Testosterone is left circulating that can then be aromatized into Estrogen than normal.
There is also the general hormonal imbalance between suppressed Testosterone levels relative to Estrogen that will also determine if gyno occurs.
If this scenario occurs and gyno starts to flare up, there is an immediate need to start an Aromatase Inhibitor (like Arimistane or Aromasin, depending on how prone you are to high Estrogen) alongside the MK-2866 to lower Estrogen levels back into range and eliminate any gynecomastia symptoms.
How long does MK-2866 take to kick in?
MK-2866 has a half-life of 23.8 hours, so it is fully active in the body the same day it is taken.
Because it is so mild side effect wise, it isn't uncommon to not actually physically “feel” any different, but the benefits it has on body composition and strength would still become noticeable regardless.
Does MK-2866 give a full look to the muscle once it’s saturated in the body?
While this is largely dictated by diet, more specifically one's carb/water/sodium intake, MK-2866 will almost certainly give a fuller look and a “pop” during a bulk phase in a calorie surplus, and help maintain muscular fullness in a calorie deficit when one would otherwise be flat.
If diet and training are in check and gaining as much muscle as possible is the goal, what kind of results can be expected (lean muscle gains wise) from a full MK-2866 cycle?
Obviously this will vary individual to individual, but I would ball park it anywhere between 5-10 pounds of solid lean muscle mass, with 5-7 being closer to the average.
I am on 250 mg per week of test cyp (125*2)… If I am on TRT would I still need PCT after a cycle?
Regardless of what you take alongside your TRT, you have exogenous Testosterone replacing what would have otherwise been suppressed by whatever else you are adding into your regimen.
There is no need to PCT if you are on TRT, the synthetic Testosterone will fulfill all physiological functions that you would have otherwise needed natural endocrine support for.
Can MK-2866 be used during PCT to preserve more muscle from a cycle?
I don't suggest it.
This is a big change from my initial impressions a few years ago because you can technically (in some cases) get away with a very low, minimally suppressive dose of MK-2866 while partially recovering during PCT and then drop it and continue PCT as normal to hypothetically retain more cycle gains from whatever you just ran.
However, I advise against it.
You are just slowing down the recovery process and hindering yourself from getting back to hormonal homeostasis as quickly as possible, which is ultimately the final goal here to maintain whatever you just gained on cycle.
Most MK-2866 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.
I strongly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.
These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure MK-2866:
Proven Peptides – 10% off coupon code “DC10”
Science.bio – 10% off coupon code “DC10”
Chemyo – 10% off coupon code “DC10”
Narrows Labs – 25% off coupon code “DC25”
Swiss Chems – 11% off coupon code “DC11”
Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.