Cardarine And SR9009 Are Not SARMs
Despite the information being readily available, most people still misguidedly believe that the best SARMs for endurance are Cardarine and SR9009.
The reason why this is comes down to the hordes of misinformation on the internet lumping compounds that are not SARMs at all into the same category as SARMs.
These compounds are absolutely effective at increasing endurance, and are more effective than SARMs at it too, however, the fact remains that the mechanism through which they facilitate this is totally different than SARMs.
Cardarine is commonly referred to as one of the best SARMs for endurance, but it is not actually a SARM at all.
Cardarine is a PPARδ receptor agonist.
To put it bluntly, you will not find anything orally bioavailable that increases endurance more than Cardarine.
Cardarine is bar none one of the most impressive endurance boosting compounds synthesized as of now.
Cardarine works by stimulating fatty acid metabolism and sparing glucose in the body.
The glucose sparing mechanism of Cardarine is facilitated by its suppression of glucose catabolism in the body, which occurs without affecting muscle fiber type or mitochondrial content.
Predictably, by suppressing the breakdown of stored glucose in the body, Cardarine delays the onset of hypoglycemia during exercise and significantly improves endurance levels.
It is most notorious for substantially extending running times, as that is what was used in a preclinical study conducted on mice as a measure of efficacy.
In a preclinical model, Cardarine nearly doubled the running distance of treated mice [R].
Expectedly, athletes using Cardarine who participate in endurance dominant sports like cycling or long distance report significant performance enhancement.
The World Anti-Doping Agency (WADA) developed a test for Cardarine and added it to their prohibited substances list in 2009.
SR9009, also referred to as “Stenabolic”, has a lot of hype behind it, but is lacklustre in real world application due to its lack of bioavailability.
Essentially, SR9009 works by increasing the mitochondria count in the muscles, resulting in a blatant improvement in endurance.
Mice treated with SR9009 showed significantly improved running endurance [R].
SR9009 is a synthetic Rev-ErbA ligand, not a SARM, although it is very commonly lumped into the SARMs category.
It is an agonist of Rev-ErbA.
Rev-erb-α-deficient mice displayed severely reduced running capacity as a result of their compromised skeletal muscle oxidative capacity, and pharmacological activation of Rev-erb-α with SR9009 greatly improved running capacity and mitochondrial respiration in mice.
Consequently, Rev-erb-α emerged as a promising regulator of skeletal muscle oxidative capacity.
SR9009 is not a potent muscle builder, which is another reason why it is so great for endurance.
Like Cardarine, it increases endurance via a pathway in the body that doesn't rely on anabolic activity via androgen receptor activation.
Without bogging the body down with increased amounts of muscle mass, SR9009 doesn’t cause a 2-step forward 1-step backward result; and instead it works by just straight up increasing cardio output capacity.
It causes no testosterone suppression, and there are no negative side effects reported to date from SR9009.
However, it has only been officially tested on mice, and never in humans.
Also, the anecdotal reports of SR9009 usage in the fitness community are almost all useless as they involve oral SR9009 ingestion, as opposed to intramuscular or subcutaneous injection.
With that being said, the minority of anecdotal reports on SR9009 injections report performance outcomes as impressive as Cardarine, as well as improved outcomes in terms of fat loss and body recomposition.
Have I tried it myself, no.
Do I plan on it, probably not, but that remains to be seen.
Supposedly, dosages of 10 – 15 mg of injectable SR9009 yielded maximal results, with dosages exceeding 15 mg yielding diminishing returns.
Dosages as low as 3 mg per day are reported to be effective in some users.
Keep in mind, there are no SR9009 studies on humans at all, and the number of individuals who have actually logged injectable SR9009 I can count on 2 hands.
There is almost no supporting data behind this compound, even anecdotally.
Factors That Will Affect Your Endurance
First of all, let me preface this by saying that the more weight your body has, whether it be muscle or fat, will make your cardiovascular system work harder, consequently needing more oxygen to function.
The result of adding weight (whether it be muscle or fat) is a reduction of cardiovascular endurance.
Even if I’m 6% body fat, at a weight of 210 pounds my endurance is terrible relative to what it was when I was a beanpole weighing 140 pounds with far less muscle mass.
The reason is that my heart and lungs have to work that much harder to operate now just to accommodate all this extra tissue.
So, the first thing I can advise is that those seeking maximum endurance lose as much weight as possible.
Second of all, if the goal is solely to gain cardiovascular endurance I advise against adding in anabolic muscle building agents like Steroids or SARMs in general.
The reason for this is essentially a reiteration of what I just said.
When you add more muscle to your frame from these compounds, you will indirectly hinder your cardiovascular endurance even further, just setting you back from your main goal.
The Best SARMs For Endurance
When it comes down to actual Selective Androgen Receptor Modulators, there are a couple that seem to exhibit more favorable performance outcomes in regards to muscular endurance improvements.
RAD140 is the arguably the best SARM for muscular endurance of all.
It adds significant amounts of strength without packing a lot of weight on, and it is dry.
It has a very obvious effect on muscular endurance that is not rivalled by any other SARMs.
Because of this, RAD140 is a very common choice of athletes and bodybuilders who's goals include body recomposition, strength gains, or overall athletic performance enhancement.
No clinical trials have been conducted on RAD140 as of now, however, recruitment is underway for its first phase 1 trial [R].
This is because it has the most clinical data and is the first SARM to have reached phase 3 trials.
Ostarine has been evaluated in 27 completed or ongoing clinical trials.
Approximately 1500 subjects in total have been treated with Ostarine, with dosages ranging from as low as 0.1 mg all the way up to 100 mg.
Ostarine was generally regarded as safe and well tolerated in all subjects at all dosage amounts.
Viking compared Ostarine to LGD-4033 milligram to milligram in their clinical data as well to exemplify how much more potent their SARM is at building muscle mass.
While several other SARMs are more potent than Ostarine, Ostarine is much less suppressive, and consequently results in a lower incidence of androgen deficiency related side effects.
This in itself makes it the most attractive choice for many individuals seeking increased muscle mass and strength, as it still has a significant anabolic effect.
While the majority of users report greater increases in muscular endurance from RAD140, a significant amount of individuals swear by Ostarine and believe it is a superior SARM for athletic enhancement.
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Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.