Will TRT (Testosterone Replacement Therapy) Cause Permanent Infertility? Thumbnail

Will TRT (Testosterone Replacement Therapy) Cause Permanent Infertility?

Will I Have Permanent Infertility From My TRT Regimen?

I'm often asked if I'm worried about permanent infertility and not being able to have children when I'm older from my TRT regimen.

If the time came, would I be able to have a kid if I'm on TRT?

The short answer is, with the right protocol, yes.

When you take exogenous hormones, TRT suppresses the feedback loop that regulates testosterone production in your body.

Your natural production of sperm can drop to infertile levels, especially if you don't use HCG alongside your TRT.

At that point, you would not be able to impregnate women and would be classified as infertile.

Many men who've been on TRT for years are walking around in a perpetual state of infertility.

I have no plans to have a kid right now or in the near future.

Am I worried about being able to have a child should I change my mind, or should the time come for me to want to have one?

No, I'm not.

If you have a properly functioning endocrine system to begin with, as long as you don't have some severe hormonal deficiency, a screwed up pituitary gland, or had one of your balls chopped off, you would be fertile if it weren't for your TRT.

Based on my experience, I have yet to hear of anyone, regardless of how suppressed they were, not achieve success in regaining fertility after utilizing an aggressive pregnancy protocol.

Dave Palumbo's Fertility Protocol

I don't know if Dave Palumbo is the first person who came up with this fertility protocol, but he's more or less seen as the face of it as of now.

Dave Palumbo's fertility protocol is a combination of HCG, HMG, and Clomid.

The protocol is as follows:

HCG – 2000 IUs every other day
HMG – 75 IUs every other day
Clomid – 50 mg a day

I know hundreds of guys that have used boatloads of gear over the years.

Some of them have been blasting and cruising for 15 years straight.

Even in the most extreme cases, when the time came for them to have a kid, the ones who followed this simple protocol were able to impregnate their wife/girlfriend:

  1. Get off steroids and TRT temporarily
  2. Get their sperm count up with the fertility protocol
  3. Get their girl pregnant
  4. Get off the fertility drugs and jump back on TRT

I have yet to hear of a situation where someone with a properly functioning endocrine system experienced permanent infertility and wasn't able to recover it with fertility drugs.

Standard Doctor Prescribed Fertility Protocols

This is not medical advice, this is just my personal opinion based on my own experiences, so don't misconstrue it as anything else.

I've seen a variety of doctor prescribed fertility protocols now, and typically, the majority of them are not satisfactory.

They often involve subpar dosages of HCG and will keep you on your TRT, or lower your dosage temporarily.

It is extremely rare for a doctor to prescribe HMG or Clomid to men, which I think are integral parts of getting your system back up to a high level of function as quickly as possible.

So, am I worried about infertility?

No, I'm not.

I'm quite confident that if I wanted to have a kid in the immediate future, I could just get off my TRT, run the HMG, HCG, and Clomid protocol, and then be fertile enough to get somebody pregnant in short order.

I know for a lot of guys, it freaks them out and prevents them from ever even exploring whether or not TRT could benefit their quality of life.

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12 thoughts on “Will TRT (Testosterone Replacement Therapy) Cause Permanent Infertility?”

  1. I would love to see a related article regarding recovery of endogenous testosterone levels versus simply achieving fertility…

    1. If you are on TRT in the first place you are already hypogonadal and have suboptimal endogenous Testosterone production, so why would you be on TRT in the first place if you wanted to cycle off to recover poor endogenous production? The reason you’re on TRT is because of the low levels you have in the first place.

  2. Hi, where would I acquire HMG? Most doctors don’t prescibe it, and there are legal options on peptide websites but I’m not sure if they work.

  3. Hi Derek,

    I just discovered I’m almost sterile, trying to have a kid and I’m pretty much helpless now. How long should I take the fertility protocol?
    The whole protocol being quite pricey (especially the HMG), do you think I can start with a lower dose protocol?

    Thanks for your help.

    1. I wouldn’t do any less than the outlined protocol personally, but you can certainly try. Some guys it only takes a bit of HCG.

  4. I have heard that exogenous DHT can cause testicular shutdown even though Clomid was used at the same time, and working, proven by high LH and FSH.

    Can HCG protect shutdowns caused by DHT?

  5. I never see you talk about it, so forgive me if I missed it. What are your thoughts on hcg with trt? I keep reading it’s important for pregnelone but I am reading conflicting stuff. Do you use it on trt? If so why or why not?

    1. I’d also like to hear your opinion on HCG and TRT Derek. It’s very difficult to find reputable information on this topic.

      My Endocrinologist recommended I take HCG during my TRT protocol (150 mg cypionate/week) to prevent testicular atrophy and maintain fertility. I cycle every 3-4 months and implement a PCT of chlomid or enclomiphene and higher doses of HCG to ensure that I can regain natural production if necessary, as I am now 27 years old. I have been cycling testosterone according to this protocol since I was 22 years old, and I just took about 6 months off. My Test levels recovered to around 700 NG/DL with a healthy free testosterone level too. (Other relevant metrics were also in range).

      HCG is quite expensive though and I’m a bit worried about the suppressive effect on the LHFSH Axis. Do you think it would be an overall better strategy to just skip the costly HCG while on cycle and reserve it for PCT?

  6. Is there any science on the likelihood of having a girl vs boy when using a fertility protocol for TRT? I’ve noticed most bodybuilders and other exogenous hormone users tend to have more girls. Does it have some impact on sperm that might cause this?

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