This article will delve into exactly what you can expect from high dose MK-677 vs low dose MK-677, and how that will correlate to your individually specific goals.
Referring to the following study we can see what HGH/IGF-1 level response is to a relatively low dose of MK-677 (10 mg per day), as well as what the response is to a high dose of MK-677 (50 mg per day).
Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.
Read the following results from this study carefully:
“After treatment with 10 mg MK-677, IGF-1 concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline).
Following treatment with 50 mg MK-677, IGF-1 concentrations increased 79 +/- 9% (84 +/- 3 to 150 +/- 6 micrograms/L, P < or = 0.05 vs. baseline) and 24-h mean GH concentrations increased 82 +/- 29% (0.21 +/- 0.02 to 0.39 +/- 0.04 microgram/L, P < or = 0.05 vs. baseline), respectively. Serum IGF binding protein-3 concentrations increased with both 10 mg (1.2 +/- 0.1 to 1.7 +/- 0.1 micrograms/L, P < or = 0.05) and 50 mg MK-677 (1.7 +/- 0.1 to 2.2 +/- 0.2 micrograms/L, P < or = 0.05).”
While there are a lot of random numbers thrown around that may seem confusing, there is one very apparent factor that becomes obvious.
The 50 mg dose of MK-677 resulted in a significantly higher IGF-1 level increase than 10 mg of MK-677 did, but an almost equivalent increase in GH concentrations.
10 mg MK-677 increased serum IGF-1 levels by 52% on average, and increased GH levels by 79% on average.
50 mg MK-677 increased serum IGF-1 levels by 79% on average, and increased GH levels by 82% on average.
What we can conclude from this is that 50 mg doesn’t result in much higher GH concentrations than 10 mg does, but it did result in significantly higher IGF-1 concentrations.
So you might still be sitting there wondering what that really means in terms of which dose you should be doing your own research with.
The answer to that lies in the difference between the function of high GH levels and high IGF-1 levels.
In general, high GH levels typically equate to more fat loss, anti-aging and healing, whilst high IGF-1 levels equate to more muscle growth.
For a more comprehensive and complete list of the benefits of HGH vs. IGF-1, please refer to my original MK-677 article.
Based on the study, if fat loss and the anti-aging/healing benefits of HGH is all that is sought after by the user, a 10 mg dose would likely be sufficient.
Whereas if the user was seeking maximized muscle growth potential, then higher IGF-1 levels would be what they are after, and would then justify a higher dosing protocol.
While this study did compare 50 mg and 10 mg dosing, delving further into other studies you will note that there is a significant diminishing returns effect on IGF-1 levels once you hit a dosage of 25 mg per day.
You can still get almost all of the increase in IGF-1 concentration with 25 mg that 50 mg would produce.
Hence, 50 mg is unnecessarily high to research with, and 25 mg is the benchmark for boosting IGF-1 levels significantly higher, while still reaping all of the benefits of the GH increase.
Keep this in mind when designing your protocol as the optimal dosage will be different based upon your specific individual goals.