High Dose MK-677 Vs Low Dose MK-677 Thumbnail

High Dose MK-677 Vs. Low Dose MK-677 Results

This article will delve into exactly what you can expect from high dose MK-677 vs low dose MK-677, and how that will correlate to your individually specific goals.

Referring to the following study we can see what HGH/IGF-1 level response is to a relatively low dose of MK-677 (10 mg per day), as well as what the response is to a high dose of MK-677 (50 mg per day).

Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.

Read the following results from this study carefully:

“After treatment with 10 mg MK-677, IGF-1 concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline).

Following treatment with 50 mg MK-677, IGF-1 concentrations increased 79 +/- 9% (84 +/- 3 to 150 +/- 6 micrograms/L, P < or = 0.05 vs. baseline) and 24-h mean GH concentrations increased 82 +/- 29% (0.21 +/- 0.02 to 0.39 +/- 0.04 microgram/L, P < or = 0.05 vs. baseline), respectively. Serum IGF binding protein-3 concentrations increased with both 10 mg (1.2 +/- 0.1 to 1.7 +/- 0.1 micrograms/L, P < or = 0.05) and 50 mg MK-677 (1.7 +/- 0.1 to 2.2 +/- 0.2 micrograms/L, P < or = 0.05).”

While there are a lot of random numbers thrown around that may seem confusing, there is one very apparent factor that becomes obvious.

The 50 mg dose of MK-677 resulted in a significantly higher IGF-1 level increase than 10 mg of MK-677 did, but an almost equivalent increase in GH concentrations.

Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men - GH Levels
Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men – GH Levels
Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men - IGF-1 Levels
Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men – IGF-1 Levels

10 mg MK-677 increased serum IGF-1 levels by 52% on average, and increased GH levels by 79% on average.

50 mg MK-677 increased serum IGF-1 levels by 79% on average, and increased GH levels by 82% on average.

What we can conclude from this is that 50 mg doesn’t result in much higher GH concentrations than 10 mg does, but it did result in significantly higher IGF-1 concentrations.

So you might still be sitting there wondering what that really means in terms of which dose you should be doing your own research with.

The answer to that lies in the difference between the function of high GH levels and high IGF-1 levels.

In general, high GH levels typically equate to more fat loss, anti-aging and healing, whilst high IGF-1 levels equate to more muscle growth.

For a more comprehensive and complete list of the benefits of HGH vs. IGF-1, please refer to my original MK-677 article.

Based on the study, if fat loss and the anti-aging/healing benefits of HGH is all that is sought after by the user, a 10 mg dose would likely be sufficient.

Whereas if the user was seeking maximized muscle growth potential, then higher IGF-1 levels would be what they are after, and would then justify a higher dosing protocol.

While this study did compare 50 mg and 10 mg dosing, delving further into other studies you will note that there is a significant diminishing returns effect on IGF-1 levels once you hit a dosage of 25 mg per day.

You can still get almost all of the increase in IGF-1 concentration with 25 mg that 50 mg would produce.

Hence, 50 mg is unnecessarily high to research with, and 25 mg is the benchmark for boosting IGF-1 levels significantly higher, while still reaping all of the benefits of the GH increase.

Keep this in mind when designing your protocol as the optimal dosage will be different based upon your specific individual goals.

These Are My Current Trusted/Go To Companies For Third Party Tested MK-677:

Science.bio – 10% off coupon code “DC10”

Chemyo – 10% off coupon code “DC10”

Amino Asylum – 20% off coupon code “DC20”

Swiss Chems – 25% off coupon code “DC25”

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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44 thoughts on “High Dose MK-677 Vs. Low Dose MK-677 Results”

    1. I’ve only used 25 mg myself so I’m not sure, I would imagine it would be a far less dramatic weight gain with the lower dose.

      1. I have been trying to convert the 10mg into millimeters as this it important for oral consumption of the liquid. It sounds like conversion depends on the density of the liquid, which I can’t find. Can someone tell me what 10mg of this translates into milliliters? Thanks.

        1. Mg doesn’t convert into ML like that. They are measuring 2 different things. For ex. I recently received a 30 ML bottle of MK677 and it is 10 mg per ML. Which means every ML has 10 mg of MK677. Some have 5, some 20 etc..

    1. I’ve covered this in my original MK-677 video. If you have cancer, don’t use HGH or MK-677. It causes hyperplasia of cancer cells only if you already have cancer. If you don’t have cancer, it will not give you cancer.

      1. Hi Derek.. I had genetic small bowel cancer 2.5 years ago and since then i am checking myself and no sign of returning disease. Can i take today MK-677?

  1. Hey Derek, really appreciate your research and detailed comments. Just interested in a few questions. Seeing as mk677 is not involving the androgen receptor, what is the initial significant weight gain from? Is it water retention or muscle creation through hyperplasia? I’ve read your article mentioning 10-20 lb gains possible just curious as a result of what?

    Other question is the effect carbs have will cycling mk677.Ive read not to take carbs with dosing and I’ve read that you can keep your diet the same as long as it’s clean.I assume it’s to do with elevated blood sugar levels and carbs would only increase that?

    Last question is with regards bloat/ water retention. What is the mk677 doing to cause water retention?

    Really appreciate your time and answers, sorry if you’ve answered them elsewhere, can’t seem to find them.
    Keep up the awesome work!
    P.s dem delt gaiiiinz are impressive!

    1. Nitrogen retention, water retention, increased blood flow, etc. The same thing as when you gain a significant amount of initial weight from AAS. The gains that are made throughout the entire cycle are comprised of muscle, the initial surge in weight gain is mostly what I just mentioned, but it looks great.

      You can have carbs, there is no reason why you would not be able to.

      GH pulses increase water retention.

  2. Quick question – how much do you think the somatostatin regulation is limiting the HGH at 50mg? If, for example, someone were to take 50 mg and Huperzine A do you think you could see a greater lift in the HGH concentration?

  3. Hey..I tried to contact neobolics to ask about third party testing and have never heard back..how do you know what their MK677 quality is if they don’t provide their own third party analysis? I can buy the liquid with third party analysis from a company in the USA but as I live in Canada I would like to buy there. I also prefer the pills over liquid due to transport ease and I don’t want the horrible taste..

    1. You’re going to be hard pressed to find any company that does HPLC testing on their raws or any kind of third party testing at all.

      EnhancedAthlete.com is actually one of the only companies who does so. Neobolics I bought based on a slew of positive reviews and I wasn’t disappointed.

      I base my MK-677 potency on how I feel for the most part, although it isn’t scientific, I’m quite in tune with my body when it comes to my GH/IGF-1 levels spiking and the effects I get when they reach a certain level. I’ve also seen IGF-1 tests that confirm the quality/potency.

      1. Thanks..I’ve think irc.bio does all the testing for their products..I may go with them even though they have the liquid..the powder they sell is raw uncapsulated. I prefer capsulated but there is too much hanky panky with supplement companies these days..even in the SARMS market..

      2. @Derek, so have you done or seen tests/results that prove the quality, effectiveness, purity, potency and legitimacy of Neobolics.com’s MK-677 to make it the approved source you listed above in the article?
        I was actually considering buying from Neobolics.com but Sarms.ca seemed more legitimate… what are your thoughts?
        I live in Canada and so it would be convenient for me to buy from a Canadian source.
        Waiting for your response…

        1. Yes or else I wouldn’t use them. I’ve never used the other site you mentioned so I don’t have thoughts on it. I know that everything I have tried from Neobolics has been spot on and they have a great price point so I don’t look elsewhere.

  4. Ill chime in here a little to provide some info.

    Ive taken both 10 and 30 mg. Ive also used GHRP’s and Real GH. I find that the least side effects but still getting benefits is best at 10 mg. From a cost & efficiency perspective MK 677 is the best out of these 3.

    I do draw issue with the 10vs25 talk here. GH rose the same in the studies in both doses but igf went from 52% increase to 79%. Yes this is a good amount of increase but nothing groundbreaking. MK 677 at 100$ a bottle is not cheap(though not GH expensive) in its own right and the higher dose probably is not worth that extra 27% increase in IGF.

    If someone is after Raising IGF particularly than taking IGF LR3 or IGF DES would be a far better choice. Both of these particularly LR3 will increase test results far more than 79%. Ive seen individuals go from 250 reading to 1000 reading on there bloodwork. These are injectable peptides keep in mind.

    The idea of raising IGF particularly is controversial as most PRO Bodybuilding experts only really advise its use if one is near there genetic maximum potential and need muscle cell hyperplasia to thus increase that potential. if a major Injury is present than perhaps there too.

    Just my two cents of info. Nothing wrong with Mk-677 it is a fantastic convenient GH product. Throwing it in a Sarm Cycle or AAS cycle is beneficial but from a cost and results perspective 10 mg is probably good enough for most people and the small % of genetic peaked individuals there probably better off with direct IGF.

    1. What about how long does it have to be taken if it is just 10mg a day? I will really appreciate the information cause I’m in doubt and only bought MK677 GH+ – 60 Capsules /10mg each, Is that enough?? just for 2 months? or one moth? Thanks in advance

  5. Nobody has mentioned the problem with this study.
    The 4 day length seems just too short. Other studies have shown that the longer it is run the higher IGF levels go(not much but somewhat). This is quite similar to real HGH blood results.

    This study cannot be concluded for much especially considering GH is more effective when taken for longer periods of time.

    Blood results between the 2 doses would have been better at 3, 6 & 12 month times.

  6. Are the gains keepable from Enhanced Athletes MK-677? I have been taking Osta from them and I lose my gains after. How do I keep my gains if I were to take MK-677?

    1. Gains are “keepable” from anything if your diet and training are in check, you PCT properly, and you aren’t past your genetic potential.

  7. Can mk 677 help you to grow past your genetic potential, like steroids do?

    I know sarms can not help you to get past your potential but i heard some people talking about mk677 could help your grow past your natural potential

  8. Have you heard anything about MK-677 decreasing insulin sensitivity?annals.org/aim/fullarticle/743451/effects-oral-ghrelin-mimetic-body-composition-clinical-outcomes-healthy-older

    1. Yes, it slightly increases fasting glucose levels, which can result in decreased insulin sensitivity (just like synthetic HGH).

        1. I wouldn’t advise someone that young to use it (I don’t feel like hormone manipulation should be done until full growth has been reached), however, what you do is entirely up to you. As for your second question, this article you are commenting on answers that exact question.

  9. Hi Derek

    Great video so thank you for that.It answered a question i have spent hours reading up on .You have really packed on some serious muscle at the making of this video by the way ….

    1. As stated in the article, 10mg yields almost the exact same GH output as a higher dose would. GH is what is responsible for the sleep benefits, hence a low dosage should result in improved sleeping.

  10. Stay on it for a year 30mg. 3 months in and I’m up 14 pounds. 193lbs to 214lbs with a minimal fat gains for a bulk. Sleep is amazing. Stay hungry.

  11. I am considering the low dose mk677 15mg for fat loss and healing run for an extended period of a year or so. Can this product be run long term or does it get less effective over time. Also I read a 5 day on 2 off protocol lessens cortisol response, is there any evidence this is the case or is it just bro science?

  12. Do you think I could take 25mg at once. Instead of taking 12.5 mg twice daily, because of the lethargy associated with taking it.?

  13. Hi Derek the mk677 tablets I have come in 20 mg tablets. I see a lot of research saying 25 mg is the sweet spot, should I just take 20 mg or take 40 mg for maximum igf-1 also if I take 2 tabs would u take all at night or split morning and night at 20 / 20

  14. Hey Derek you stated 10mg is basically the dosage for people who want the health and hair benefits. I was wondering if this dosage is safe to stay for a long period of time? and how would you dose off if needed? Last question if your peaked to having some recession at age 30, and you’re taking a low dosage of MK at age 24 cycling off and on if needed will it cause you have some recession that you’re already prone to have earlier?

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