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MK-677 (Ibutamoren) – Results, Clinical Trials & Reviews

Ibutamoren (developmental code name MK-677) is an orally-active growth hormone secretagogue and ghrelin receptor agonist being researched as a potential treatment for growth hormone deficiency and sarcopenia [R, R, R, R, R].

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What Is Ibutamoren (MK-677)?

Ibutamoren (MK-677) is a growth hormone secretagogue and ghrelin receptor agonist.

It increases the endogenous secretion of GH and IGF-1.

A growth hormone secretagogue is simply a substance that signals the pituitary gland in your body to secrete more growth hormone.

MK-677 is orally bioavailable, therefore it can be swallowed (no injections needed) [R].

To date, there have been no viable orally bioavailable alternatives to synthetic human growth hormone injections.

Much like SARMs, it is non-steroidal, but contrary to popular belief, MK-677 is not a SARM in any capacity, despite commonly being thrown into that category.

MK-677 will not negatively affect natural testosterone levels or endocrine function in any capacity at all, as it does not suppress any male sex hormones.

MK-677 has a much longer shelf-life than reconstituted GH, and does not need to be stored in the fridge or freezer to prevent degradation [R].

Clinical trials are currently assessing how viable of a potential treatment MK-677 is for addressing growth hormone deficiencies, muscle wasting diseases, Osteoporosis and a myriad of other related conditions.

MK-677 Effects

Increases Bone Density

In a 12 month study conducted on postmenopausal osteoporotic women, 25 mg of MK-677 per day increased bone mineral density and was well tolerated without any significantly concerning side effects [R].

In a 2 month randomized, double-blind, parallel, placebo-controlled study on 24 healthy obese men (ages 19-49), 25 mg of MK-677 per day increased markers of bone formation within the first 2 weeks, and increased serum osteocalcin levels at the 2 month mark.

Predictably, large increases in serum IGF-1 levels were also noted [R].

In a clinical study evaluating the changes in serum IGF‐I and markers of bone turnover in 187 elderly adults (65 years or older) lasting 2–9 weeks, dosages of 10-50 mg were administered once daily.

All treated individuals experienced increased bone turnover, regardless if they were healthy or functionally impaired men or women [R].

Builds Muscle

Growth hormone (GH) can accelerate lipolysis, and has an an anabolic effect in muscle tissue by increasing insulin-like growth factor (IGF)-I and nitrogen retention [R].

In a 2 month study on 24 healthy obese men using 25 mg of MK-677 per day, 3 kg of lean muscle mass was gained in the MK-677 treated group compared to the placebo group.

According to a DEXA scan, total body fat did not change during the study, equating to a gain of 6.62 pounds of muscle in the MK-677 treated group [R].

It should be noted that this conclusion has limitations, due to the fact that intracellular water very likely contributed a fair portion of that “fat-free mass” that was gained.

In another study conducted on sixty-five healthy men and women ages 60-81, 25 mg MK-677 per day increased fat-free mass (FFM) by 1.6 kg relative to placebo.

The average lifetime loss of fat-free mass in adults is ~ 5.5, therefore MK-677 has exhibited the potential to offset aging induced catabolism by as much as 29% [R].

Increases BMR

Basal Metabolic Rate (BMR) was increased by MK-677 at 2 weeks of treatment, even after correction for the increase in fat-free mass [R].

Due to its positive effect on body composition, there is a case to make in regards to MK-677 being a possible treatment for obesity.

BMR (a) and BMR corrected for the increase in FFM (b) during 2-month treatment with MK-677 (25 mg) or placebo daily
BMR (a) and BMR corrected for the increase in FFM (b) during 2-month treatment with MK-677 (25 mg) or placebo daily

Increases Nitrogen Retention

Ibutamoren exhibits blatantly anti-catabolic properties, one of which is its ability to retain nitrogen even in a steep caloric deficit.

Eight healthy volunteers (ages 24–39 yr) were calorically restricted (18 kcal/kg·day) for two 14-day periods.

During the last 7 days of each diet period, subjects received either oral MK-677 25 mg or placebo once daily.

MK-677 reversed nitrogen wasting caused by the caloric deficit, suggesting that if these short-term anabolic effects are sustainable, it could be a viable treatment for those experiencing chronic disease, or other muscle wasting catabolic conditions [R].

Improves Sleep Quality

A study with eight young subjects (18-30 years) and six older subjects (65-71 years) found that MK-677 was able to increase REM sleep by as much as 50% [R].

Many anecdotal logs report much deeper sleep as a result of MK-677 usage as well (myself included).

Longevity

Natural Growth Hormone secretion downregulates with age, consequently lowering serum IGF-1 levels in the body, which results in significant lean muscle catabolism and increased mortality [R, R].

By restoring GH and IGF-1 levels to that of young healthy adults, it is likely that a significant amount of muscle and bone degradation could be prevented entirely.

In a study conducted on sixty-five healthy men and women ages 60-81, 25 mg MK-677 treatment per day resulted in increases in GH and IGF-1 levels to levels seen in young adults [R].

In another study conducted on one hundred sixty‐one hip‐fracture patients aged 65 and older, 25 mg MK-677 treatment per day increased serum IGF‐I levels by 84% [R].

Higher levels of IGF-1 are also associated with longer telomere length (a generally accepted marker of aging) [R].

Improves Immune System

A study on mice showed that a growth hormone secretagogue could generally duplicate the same enhancement of the immune system observed by treating mice with synthetic GH injections.

Statistically significant changes in immunological parameters in the young and old mice treated with the growth hormone secretagogue were noted.

Tumor resistance increased substantially, and there were signs of anti-aging whereby a deficiency in the thymus in mice (a result of aging) was reversed entirely [R].

Currently, growth hormone injections are an approved treatment for treating muscle wasting caused by AIDS, and the findings in this study would suggest that a growth hormone secretagogue like MK-677 could fulfill a clinical need for AIDS patients and individuals undergoing chemotherapy and irradiation.

It would also have the obvious advantage of being orally bioavailable, whereas GH can only be administered via injection.

Hair Loss Prevention

IGF-1 has been shown to affect follicular proliferation and differentiation, remodelling of tissue, as well as the hair growth cycle itself.

More evidence is arising to suggest that IGF-1 plays an important role as a regulator in hair follicle biology.

It should be noted that patients with growth hormone (GH) deficiency resulting from defective hormone binding with low serum IGF-1 levels exhibit very sparse hair growth [R].

Anecdotally, several users of synthetic GH injections and Ibutamoren have reported a faster growth rate of their hair, as well as improved overall hair density.

Prevention Of Growth Hormone Deficiency

MK-677 has exhibited the ability to increase serum GH and IGF-1 levels to that of a young healthy adult, thus it was obviously desirable to assess if it could be a potential alternative treatment to growth hormone injections for those diagnosed with growth hormone deficiency.

In a study conducted on nine severely GH-deficient men ages 17-34 yr who had been treated for GH deficiency with GH during childhood, once daily dosages of 10 or 50 mg MK-677 or placebo were administered.

10 mg MK-677 increased serum IGF-1  levels by 52% on average, and increased GH levels by 79% on average.

50 mg MK-677 increased serum IGF-1 levels by 79% on average, and increased GH levels by 82% on average.

These improvements are indicative of Ibutamoren's potential as an alternative form of treatment for GH deficiency during childhood [R].

Mechanism Of Action

Growth hormone is secreted by the somatotrophes of the anterior pituitary gland in multiple pulses each day.

Growth hormone is released into the blood stream and then stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which stimulates linear growth before epiphyseal fusion and also exerts several metabolic effects throughout life.

After ingestion, MK-677 increases somatotrophe secretion of GH via signalling the pituitary gland to secrete a sufficient amount of growth hormone [RR].

The most common cause of GH deficiency in childhood is believed to be caused by a lack of adequate stimulation of the pituitary gland by hypothalamic GHRH, which is why something like Ibutamoren which can systemically increase IGF-1 levels for 24 hours with a single oral dose is very promising for potential clinical use [R].

The likely mechanism of action following MK-677 administration is the activation of the ghrelin receptor by MK-677, with feedback by IGF-I preventing excess GH production [R].

The mechanism of action through which MK-677 promotes GH secretion is comparable to growth hormone releasing peptides like GHRP-6, GHRP-2, Ipamorelin and Hexarelin, with GHRP-6 being the most similar in regards to the amount of ghrelin secretion that occurs post-administration.

MK-677 does not stimulate a greater quantity of secretion events per day (number of GH pulsations), but rather it stimulates a greater total 24 hour GH production rate [R].

In other words, Ibutamoren can substantially increase the strength of each GH pulsation that occurs in the body.

EFFECTS OF TREATMENT ON 24-H MEAN GH AND IGF-I AND GH SECRETORY DYNAMICS
Effects of treatment on 24-hour mean GH and IGF-1 and GH secretory dynamics

Benefits Of Higher GH Levels and IGF-1 Levels

Healthy GH and IGF-1 levels support a variety of positive benefits in the body.

As mentioned earlier, these benefits include anti-aging properties, which is why HGH is commonly referred to as the real “fountain of youth.”

GH Benefits

  • GH promotes and increases the synthesis of new protein tissues, allowing new muscle to be built
  • Metabolizes fat incredibly well, improves complexion,
  • Has dramatic anti-aging properties
  • Increases hair growth (where you want it)
  • Improves sleeping patterns (making for fewer unintended awakenings and better REM-stage sleep)
  • Produces more energy
  • May improve sexual performance
  • Increases bone density which prevents injury and helps promote healing
  • Can improve the quality and duration of heart and kidneys

IGF-1 Benefits

  • IGF-1 supports cellular division (hyperplasia), making it the only hormone that can actually create brand new muscle cells via muscular cell division.
  • Supports the repair of nerve damage
  • Lowers body fat levels
  • Exhibits anti-aging properties by tightening up loose skin
  • Aids in the repair of bones, tendons and ligaments.

IGF-1 Hyperplasia

The cellular division aspect of IGF-1 is what makes it so attractive to bodybuilders and athletes, as an individuals “genetic potential” essentially refers to how much hypertrophy can be induced in a person's muscle cells.

Only so much hypertrophy can be achieved, even with the addition of exogenous anabolic steroids and/or insulin.

The two primary mechanisms by which muscle mass may be increased are hypertrophy (increase in myofibre size), and hyperplasia (increase in myofibre number).

It is generally well accepted that there are a fixed amount of fibres within a muscle, however, it has been suggested that cell splitting can occur in these fibres [R].

While there is no evidence of this in humans via clinical studies, bodybuilders hypothesize that supraphysiological amounts of IGF-1 in the body can cause cellular hyperplasia, whereby myofibres split in two, to create brand new muscle fibres.

In theory, via this process, one could split new muscle cells, and then induce hypertrophy in those new muscle fibres and achieve greater levels of musculature than would have been possible otherwise via resistance training, diet and hormonal assistance.

MK-677 Clinical Trials 

Lumos Pharma acquired the license for Ibutamoren (MK-677) in September, 2018 [R].

The compound was thereafter referred to as “LUM-201” by the company.

LUM-201 Pipeline
LUM-201 Pipeline

Right now, MK-677 (LUM-201) is in phase 2 trials being investigated as a potential treatment for Pediatric Growth Hormone Deficiency (PGHD).

To date, MK-677 has been studied in more than 1200 people (~200 children and~1000 adult and elderly patients), and was generally well tolerated.

MK-677 Limitations

While MK-677 will effectively stimulate the secretion of growth hormone in those with a functioning hypothalamic pituitary adrenal (HPA) axis in most cases, there are certain scenarios in which it is ineffective.

  1. Individuals who have a non-functioning hypothalamic pituitary adrenal (HPA) axis
  2. Individuals who are unable to secrete growth hormone
  3. Individuals who simply do not respond to MK-677 at all
  4. Approximately 30% of children with PGHD will not be able to restore healthy GH and IGF-1 levels with MK-677 treatment

MK-677 Results (Anecdotal/Recreational Use)

There are several testimonials online reviewing Ibutamoren's applications in a performance enhancing context.

These logs are anecdotal, but anecdotal experiences still can provide insight into how MK-677 performs in scenarios that will very likely never be assessed in clinical studies.

In certain cases, anecdotal logs can actually be far more revealing of important information than clinical studies.

A good example of that is the selective androgen receptor modulator (SARM) Andarine and its potential to cause temporary vision impairment, which is a side effect that was not discovered during its development (although perhaps it could be the reason why it was abandoned).

Anecdotal experiences of Ibutamoren commonly compare its effects to synthetic GH injections.

It is becoming more common for athletes seeking performance enhancement to turn to MK-677 before GH due to the prohibitive costs of HGH, the convenience of oral administration over injections, more flexible storage requirements, and nearly identical results when comparing Ibutamoren to modest dosages of daily GH injections.

Gains of 5-10 pounds of fat-free mass within the first few weeks of MK-677 use are commonly reported, however, it should be noted that the majority of that is intracellular water.

My MK-677 ReviewMK-677 Results

I have used MK-677 a few times over the past couple years now.

Each time the results have been fairly dramatic, even while on moderate dosages of anabolic steroids.

In my experience, intramuscular water and nitrogen retention is more apparent with MK-677 than GH.

That can be a good and bad thing though, depending on the goals of the user.

Every time I have used MK-677, within a week my weight would jump up 7-10 pounds.

The only thing that I can think of that will make more of a dramatic difference in that short a span of time is Dianabol.

This isn't necessarily a positive thing though, and can actually be seen as a negative, depending on the goals of the user as I mentioned above.

If I had to compare 25 mg of MK-677 to something I would compare the results to 3-4 iu’s of high quality generic GH paired with a few daily 100 mcg injections of GHRP-6 coupled with concurrent 100 mcg injections of Modified GRF (1-29).

I also experience ravenous hunger that makes it nearly impossible to adhere to a reasonable caloric intake.

This is due to the increased ghrelin secretion that MK-677 induces.

The incredibly heightened appetite is the main reason I avoid this compound now, as I cannot cut down to sub 10% body fat when I have above average levels of ghrelin being secreted around the clock.

Ghrelin secretion seems to subside to a large extent after attenuation of Ibutamoren's effects starts to set in, which makes it more tolerable, but I now avoid suing ghrelin mimetics entirely unless I am eating above maintenance.

I've also noticed that MK-677 seems to very significantly offset hair loss.

Every time I use MK-677, my hair grows much faster, and there is a remarkable improvement in my hairs overall density.

Areas that are normally more diffuse than I prefer fill in quite a bit, very quickly whenever I use MK-677.

It has become my candidate of choice among growth stimulators for hair loss prevention.

In terms of side effects, I have noticed some fairly significant lethargy from MK-677 (anything that raises GH and IGF-1 will do this), however, I was able to mitigate that to some extent by taking my daily dosage right before going to bed.

MK-677 Dosage 

MK-677 exhibits a dose dependent positive effect on serum GH and IGF-1 levels.

The clinical data suggests that Ibutamoren begins exhibiting diminishing returns above and beyond dosages of 25 mg per day.

The remains consistent among the majority of the clinical studies, with almost every trial utilizing a once daily oral dosage of 25 mg of MK-677 to assess Ibutamoren's efficacy relative to placebo.

When comparing high dosages of MK-677 to low dosages, there wasn't a significant difference between GH levels at dosages of 10 mg and 50 mg per day, however, there was a significant difference in serum IGF-1 levels between the 10 mg per day dosing group, and the 50 mg per day dosing group.

In severely GH-deficient men ages 17-34 yr, on average, 10 mg MK-677  increased serum IGF-1  levels by 52%, and increased GH levels by 79%, while 50 mg MK-677 increased serum IGF-1 levels by 79%, and increased GH levels by 82% [R].

How Much Does MK-677 Increase GH And IGF-1 Levels?

MK-677 has exhibited substantial increases in serum GH and IGF-1 levels in multiple clinical trials now.

In a 12 month study conducted on postmenopausal osteoporotic women, 25 mg of MK-677 per day administered with or without alendronate for 12 months increased IGF-1 levels by approximately 40%.

Serum IGF-1 levels appeared to start tapering down over the next 11 months after they peaked in month 1. This suggests that utilizing MK-677 in a cyclical fashion may be a more beneficial way of maximizing its efficacy during use [R].

In the 2 month study on 24 healthy obese males , after two weeks of treatment with 25 mg of MK-677 per day serum IGF‐I levels increased approximately 40% compared with pretreatment values and this effect was sustained throughout the treatment period [R, R].

Serum concentrations of IGF-1 and IGFBP-3 during 2-month treatment with MK-677 (25 mg) or placebo daily in obese males
Serum concentrations of IGF-1 and IGFBP-3 during 2-month treatment with MK-677 (25 mg) or placebo daily in obese males

In a 2 year study including sixty-five healthy men and women ages 60-81, daily MK-677 significantly increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects [R].

Serum 24-h mean GH results in pivotal year 1
Serum 24-h mean GH results in pivotal year 1
Serum 24-h mean IGF-1 results in pivotal year 1
Serum 24-h mean IGF-1 results in pivotal year 1

In a study conducted on nine severely GH-deficient men ages 17-34 yr, 10 mg MK-677 increased serum IGF-1  levels by 52% on average, and increased GH levels by 79% on average.

50 mg MK-677 increased serum IGF-1 levels by 79% on average, and increased GH levels by 82% on average [R].

Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men - GH Levels
Placebo Vs 10 mg MK-677 Vs 50 mg MK-677 in GH deficient men – GH Levels
Placebo Vs 10mg MK-677 Vs 50mg MK-677 in GH deficient men - IGF-1 Levels
Placebo Vs 10 mg MK-677 Vs 50 mg MK-677 in GH deficient men – IGF-1 Levels

MK-677 Bulking Cycle

In a calorie surplus MK-677 will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

SARMs like LGD-4033, Ostarine, RAD140 or S4 are commonly stacked alongside MK-677 in more involving performance enhancement bulking protocols.

Side Effects

Increased Appetite

MK-677 will almost undoubtedly greatly increase appetite.

Besides acting as a potent growth hormone secretagogue, MK-677 is also an oral ghrelin mimetic.

Ghrelin is the “hunger hormone” that your stomach secretes in order to regulate your appetite.

By artificially stimulating the secretion of that hormone, the body is tricked into being hungry, even when it wouldn't have been otherwise.

MK-677 has a very significant effect on Ghrelin, more so than any other ghrelin receptor agonist with the exception of GHRP-6.

How MK-677 and GHRP-6 differ is that GHRP-6 is in and out of the body very quickly (half-life of 20 minutes), whereas MK-677 will stimulate ghrelin secretion for several hours, thereby resulting in greatly increased levels of hunger all day long [R].

While MK-677 has a positive effect on body composition, I don't believe the clinical data takes into account how important diet adherence really is when it comes down to what will get someone in shape.

In almost all cases, having chronic ghrelin secretion being stimulated would make it nearly impossible to stick to a strict caloric deficit in order to reap the true metabolic benefits that Ibutamoren can provide in the first place.

It's easy to see why this compound is recreationally used so often as an appetite stimulant, as the ghrelin secretion properties are incredibly potent.

Lethargy

Though not reported in the clinical data, I can assure you that anything that increases your GH and IGF-1 levels will increase your lethargy.

Regardless if GH/IGF-1 is increased via synthetic gh injections, growth hormone releasing peptides, or growth hormone secretagogues like MK-677, increased levels of lethargy is an expected and common side effect.

Intense Dreams

Dreams (both lucid and non-lucid) are much more common during the REM cycle of sleep.

As sleep affects the regulation of growth hormone (GH), typically, getting a deep and restful sleep is associated with optimal growth hormone secretion, and consequently, more dreaming [R].

Stimulation of endogenous GH secretion with MK-677 can improve sleep quality, promote the body to enter the REM cycle, and in turn experience more dreams.

Water Retention

A common side effect from elevated GH and IGF-1 levels is water retention.

Expectedly, the most common side effect aside from increased appetite was transient edema and muscle pain in clinical trials [R].

The muscle pain likely being an indirect side effect caused by intracellular water retention putting increased stress on the joints and muscles.

Increased Blood Pressure

Increased blood pressure is an indirect side effect resulting from edema, which is one of the most common MK-677 side effects [R].

Elevated Blood Sugar & Reduced Insulin Sensitivity

Although several clinical studies found no change in blood glucose levels, there were a couple studies where MK-677 caused an elevation of fasted blood glucose levels and decreased insulin sensitivity [R, R].

GH causes blood sugar levels to rise, which in turn requires the pancreas to work harder to compensate and release insulin to bring blood sugar levels back down to homeostasis.

Chronic GH elevation can create chronic pancreatic stress in certain scenarios, which eventually can result in pancreatic beta cell degeneration, and insulin resistance.

Chronic blood glucose elevation and pancreatic cell degeneration is what eventually leads to Type 2 Diabetes.

Individuals with other lifestyle factors that contribute to insulin resistance as is (excessive carbohydrate intake, holding too much body fat, lack of exercise, etc.), or have genetic predispositions that increase their likelihood of Diabetes, could potentially end up pushing themselves over the brink and become Type 2 Diabetic with MK-677 or synthetic growth hormone usage.

Reactive Hypoglycemia

MK-677 can raise blood glucose levels, which is a mechanism that is autocorrected and regulated by the pancreas in healthy individuals.

In insulin resistant individuals, MK-677 can cause reactive hypoglycemia, whereby sharp spikes in blood sugar can cause an exaggerated level of insulin secretion and glucose uptake into the cells, consequently crashing blood sugar and causing hypoglycemia [R].

This poor endogenous regulation of blood glucose levels is typically indicative of some degree of insulin resistance in an individual.

Signs and symptoms of reactive hypoglycemia may include hunger, weakness, shakiness, sleepiness, sweating, lightheadedness and anxiety.

Potential Cancer Cell Hyperplasia

Despite the clinical data showing a positive effect on resistance to tumor progression and upregulation of the immune system in mice, the proliferative properties of IGF-1 inherently suggest that MK-677 could potentially accelerate the growth rate of existing cancer cells in the body.

This is why Metformin is shown to help prevent cancer, because it lowers serum IGF-1 levels in the body.

This is also an argument commonly made as to why high levels of IGF-1 will shorten the lifespan of a person, rather than extend it.

Tingly Or Numb Fingers And Hands

This is a common side effect of elevated growth hormone levels, and is commonplace among anecdotal reports on Ibutamoren.

Enhanced Fear In Rats

One study on rats evaluated MK-677's potential to cause enhanced levels of fear.

There is evidence to support that one of the ways ghrelin is modulated is through exposure to stress.

What this study intended to assess specifically was if rats would have a greater likelihood of experiencing fear and posttraumatic stress disorder (PTSD) when their ghrelin levels are artificially raised 24/7 with a ghrelin receptor agonist (MK-677).

So, rats were continuously administered MK-677, and frightened constantly, and their difference in response (MK-677 treated vs non treated) was assessed.

The rats with chronic ghrelin elevation were found to have enhanced fear memory compared to baseline [R].

This same response has yet to be replicated in human trials, or in anecdotal logs.

PCT (Post Cycle Therapy)

MK-677 does not cause endocrine suppression, it doesn't lower natural testosterone levels, and it doesn't inhibit LH, FSH or SHBG [R, R].

It does not raise estrogen either, which has an indirect effect on testosterone suppression [R].

As MK-677 doesn't suppress any sex hormones, or increase any antagonizing hormones, there is no hormonal suppression that occurs via MK-677 use, and therefore would not require a PCT phase.

Half-Life

The elimination half-life of MK-677 is 4.7 hours; with IGF-1 levels remaining elevated with a single oral dose for up to 24 hours [R].

Once per day dosing of MK-677 has proven to be a viable frequency of administration throughout all of the clinical studies to date.

MK-677 Vs HGH Injections

The majority of competitive bodybuilders and other performance enhancement seeking athletes view growth hormone as a valuable tool for enhancing their muscle growth and fat loss potential.

However, legitimate GH is simply unaffordable to most.

With a pharmacy-grade kit of GH being upwards of $600-1000 in many instances, it can be extremely cost prohibitive just to use a modest dosage on a daily basis.

With MK-677 exhibiting effects formidable to that of a modest dosage of pure GH in clinical trials, it is easy to see why it has garnered so much attention from those seeking performance enhancement.

MK-677 also has the advantage of being stable in room temperature, orally bioavailable, sustaining elevated IGF-1 levels 24 hours post-ingestion, and works via stimulating natural endogenous GH secretion, as opposed to exogenous synthetic GH injections which will increase serum GH levels irrespective of the body's current endogenous production without a feedback loop to regulate that hormone levels stay within healthy limits.

MK-677 Vs Peptides

The main drawback of growth hormone releasing peptides (GHRP's) is that they all require 3-6 injections per day to sustain stable blood serum concentrations because of their short half-lives.

MK-677 does not have this same issue, as once per day dosing elevates IGF-1 levels for up to 24 hours [R].

Although fast acting GH peptides can be effective, they are certainly not convenient at all, and just the nuisance of their required dosage frequency alone would likely drive away most people from considering it a viable GH alternative.

Another major disadvantage of GHRP's is their inhibited effects in the presence of glucose.

GHRP injections need to be timed correctly as elevated blood glucose levels render them dramatically less effective.

When the dosage frequency of a GHRP requires 3+ injections per day to achieve stable blood serum concentrations of GH and IGF-1, ensuring that blood glucose levels aren't elevated at the time of injection during each of these shots is extremely difficult, if not nearly impossible for individuals who aren't sitting at home doing nothing day in and day out.

Peptides also have the same limitations as GH, where they must be reconstituted, injected, and stored in a fridge to avoid degradation.

While comparing the pros and cons of MK-677 to peptides, the clinical data is generally in favor of MK-677.

However, it should be noted that there are a couple very effective combinations of the two where IGF-1 levels equivalent to high dosages of pharmaceutical grade GH can be achieved.

Supplements To Take With MK-677 (Optional)

Huperzine A 

Certainly not mandatory, but if you want to maximize the benefits you can get from MK-677 it may be worthwhile to look at Somatostatin inhibitors.

A popular supplement that is commonly used with MK-677 is Huperzine A dosed at 200 mcg three times per day.

There are a couple studies with data that are often extrapolated to suggest that Huperzine A is a potent Somatostatin inhibitor [R, R].

When your body has higher than normal HGH levels, it will release Somatostatin as a counter measure to inhibit the secretion of growth hormone from somatotrope cells to bring HGH levels back to normal.

This mechanism is very similar to how the body uses Myostatin to inhibit excessive muscle growth.

In theory, Huperzine A would prevent Somatostatin from inhibiting pituitary released GH, and by using Huperzine A to inhibit Somatostatin, your body would then have more active/usable HGH.

This is all hypothetical, and the evidence to support the efficacy of Huperzine A in this process is weak.

However, Huperzine A is still a great Nootropic supplement, and it is very cheap.

I use it daily anyways, and if it inhibits Somatostatin then I just see it as a fringe benefit.

The reality is that the likelihood of it having a significant impact on the process of endogenous GH inhibition is low.

Insulin Mimetics

As MK-677 can increase your blood glucose levels via increased endogenous HGH production, using supplements as a countermeasure to keep your blood sugar lower and more stable may be a wise decision.

Insulin is what is responsible for shuttling nutrients to the muscle for recovery, and it has a direct and major impact on how both your muscle and fat cells utilize amino acids and glucose.

When your insulin sensitivity is high, muscle cells will readily absorb glucose and amino acids when insulin signals them to open.

However, when your insulin sensitivity is low as a result of having a high level of body fat accrued on your physique, eating too many high glycemic carbohydrates (or too many carbs in general), among other potential risk factors, your natural levels of insulin are so much higher that it can have a severe desensitizing effect on muscle cells and insulin’s nutrient shuttling effects.

Compounding the issue, with diminished insulin sensitivity your body will become more and more prone to convert more of the excess calories you intake as body fat, as the muscle cells are no longer absorbing and utilizing the consumed glucose and amino acids efficiently.

Berberine

Berberine is arguably the best over the counter supplement to improve insulin sensitivity.

Clinical research has shown that Berberine greatly promotes glucose absorption by muscle cells, and is so effective at reducing blood glucose levels it is comparable to Metformin (a prescription drug for blood sugar control).

*One important thing to note about Berberine is that it inhibits the enzyme CYP3A4, a member of the Cytochrome P450 family. This enzyme directly dictates how fast the liver can break down medications. Because of this, Berberine may slow down the rate at which the liver breaks down medications, equating to potentially longer life spans of medications you are using, as well as potentially inducing stronger overall effects from those medications than intended. One example in particular is if you are on TRT and use an Aromatase Inhibitor (AI) to keep your Estrogen levels in the sweet spot, having Berberine in your system may potentiate the effects of that AI (as the liver isn't breaking it down as efficiently as normal), which could potentially tank your Estrogen far below what it would normally be at on that same AI dosage without Berberine in your system. Keep this in mind prior to the usage of Berberine.*

Some other effective supplements at controlling blood sugar are

Cinnamon Extract 

Cinnamon Extract has potent anti-diabetic effects, proving to aid insulin function by a significant degree (more than 20-fold in vitro), reducing blood glucose levels, and even improving blood lipid profile.

Other studies also noted blatant improvements in overall insulin sensitivity.

Alpha Lipoic Acid 

A decrease in blood glucose is noted with oral supplementation of Alpha Lipoic Acid, encouraging heightened insulin sensitivity and nutrient partitioning.

Fenugreek 

Clinical research has shown that Fenugreek lowers blood glucose levels and improves the body’s tolerance to glucose itself.

Fenugreek has even been used to mitigate blood sugar metabolism problems like Diabetes.

Kaempferol 

Kaempferol encourages glucose uptake into myocytes and has been alleged to be as potent as insulin itself in regards to this process in particular.

It may also inhibit the enzyme responsible for the production of fatty acids deriving from glucose, meaning more fat loss (or less fat gain depending on the scenario).

Myricetin

Proven to improve blood glucose uptake, Myricetin decreases blood glucose levels and can actually aid in the reversal of the negative effects caused by metabolic syndrome.

The mechanism of action behind Myricetin’s benefits are similar to that of Kaempferol, and it also inhibits the uptake of glucose into fat cells, equating to less fat storage.

Irvingia Gabonensis

Irvingia Gabonensis reduces blood glucose levels and reduces fat storage through several anti-obesity mechanisms such as the inhibition triglyceride uptake.

Fucoxanthin

One study found a huge increase in metabolic rate with the supplementation of Fucoxanthin, roughly equating to an increased metabolic rate of around 450 calories per day.

This was one study though and requires replication to see if those astounding results can be achieved with other sample groups as well.

Regardless, it seems like a very promising compound, and it also was shown in studies to result in a significant decrease in blood glucose, and a significant increase in the uptake of glucose into skeletal muscle.

Chromium

Chromium is an essential mineral that regulates blood glucose, insulin metabolism, and can encourage insulin sensitivity in the body.

Appetite Suppressant

If you are dead set on cutting with MK-677 to get shredded, I highly suggest you get an appetite suppressant, as MK-677 will almost certainly increase your appetite significantly.

To be honest, I advise against cutting on MK-677 entirely unless you have adapted to the Ghrelin spikes.

If you are just starting MK-677, I can almost guarantee you that you will not be able to adhere to a strict diet and calorie deficit with the intense hunger that MK-677 induces when you first start using it.

GH Gut 

MK-677 will not directly cause “GH gut.”

However, it can contribute to it.

GH gut is something that is commonly attributed to the abuse of human growth hormone, however, MK-677 does not increase serum GH and IGF-1 levels in the body as high as supraphysiological dosages of growth hormone.

While it will increase blood sugar, it has not shown to be independently capable of causing GH gut without compounding factors like suboptimal body composition, poor diet and exogenous GH injections.

There is no documented case of this, I'm just asserting a hypothetical perfect storm scenario in which high levels of insulin resistance and compromised gut health could occur that would lead to “GH gut.”

Buy MK-677

Most MK-677 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I highly advise that before you buy SARMs or MK-677 from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure MK-677:

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Be sure to check all laws in your country prior to buying anything to make sure it is compliant where you live with your current government laws.

209 thoughts on “MK-677 (Ibutamoren) – Results, Clinical Trials & Reviews”

  1. Is there a minimum age you would recommend for taking this, or SARMS for that matter? I know a lot of people say 25 minimum for anabolics, would that be true of this and SARMS as well?

    Im 20 years old, and developed pretty early, I was my full height (6’5″) at 14. Im interested in these but don’t want to mess with my endocrine system or any remaining devlopment.

    Thanks and great site!

    1. Remember that SARMs aren’t NEARLY as suppressive as steroids are, so it will be impossible for SARMs to permanently “mess with your endocrine system” if you follow a safe dosing protocol and cycle length and do a mini-pct after each cycle. At your stage of development SARMs will be fine to use soon. Maybe wait until you’re 21 if you want to really go by the book, but ultimately it is up to you.

      1. What sarms should I use for rapid fat loss? I tried cardarine and I’m gaining weight and bloating. I’m using hardcore supplements so maybe not a bs sup

        1. SARMs don’t burn fat, neither do Steroids. Diet and cardio and expending more energy than you take in burns fat.

      1. Is there any need to take insulin along with mk677? Doesort it mess up with your natural insulin production or raise blood sugar.thanx

  2. Couple of questions:

    1) Is it okay to refrigerate this? It’s starting to heat up where I live so storing at room temperature might not be appropriate.

    2) Do you take this on an empty stomach?

    1. Yes you can refrigerate it. Room temp is ideal though.

      If you hold it under your tongue for 30 seconds the grain alcohol pulls a lot of the MK directly into your blood stream sublingually. As long as you aren’t loaded up on sugar causing a massive insulin spike then I think you’ll be fine dosing it having eaten recently. I’m never in a fasted state except when I wake up anyways, and I take MK-677 pre-bed and it works just fine for me.

  3. This is a mini review of MK677 with ostared. Derek didn’t ask me to do this and he has been great to me answering questions over email and here. Just a little background of myself. I’ve been working out for about 3 years and am somewhat knowledgeable about bodybuilding. I’m a hardgainer which makes it easy for me to get shredded but hard to pack on muscle. I’ll also try to update once a week and will try to answer questions. FYI I just dose 18 drops of MK, which is probably roughly a ml.

    I’ve been on osta for about a week and this is about my fourth day on mk and creatine. I do not experience the tingly hands, numb hands, or crazy dreams. At best my appetite may have increased a tad bit. I also can’t vouch for the lethargy since I cycle coffee and can crash.

    With all this being said, the side effects are nothing less than surprising. My muscles are much fuller than when I’m not on all these supplements. Yes I know creatine inflates your muscles but this is just ridiculous. Also maybe my memory isn’t serving me correctly but creatine doesn’t pump your muscles up in just 4 days.

    I haven’t worked out in a couple of days but when I got back to the gym (I use machines 99% of the time) my strength was VASTLY improved. Please note I cannot honestly say which supplement is doing what, but I think if you consider all three that should get you what you want. Also, food is necessary to pack on mass using supplements will not turn you into Hulk Hogan.

    Getting back to the results…..I was just playing around at the gym. I do not normally leg press but I can now press one rep of 415. Row 185 at 5 reps at a time. Chess press (my primary weakness) is slightly improved at 170. Total weight for all 3 is 770. These are numbers I could reach when I was 10-15 pounds heavier and starting out but not on all these supplements (exception is creatine). I want to reach 840 total weight, with my chest press shooting up to 230, along with more reps and sets. The other two lifts are nearly maxed out.

    To sum up, the results are promising. My strength has definitely increased and it’s not a placebo. I’ll try again tomorrow and be a bit more serious.

  4. Update 2:

    My weight is up 5 pounds. Endurance and strength has greatly improved. I usually get tired at the 10-20 minute mark but with the current stack I feel like I can workout for an hour if I wanted too. I usually shoot for 30-45 minutes. My muscles feel very full.

    My appetite isn’t too crazy but if I have to guess I’m eating 600-700 more calories than usual. Still no crazy dreams and can’t confidently say if my sleep has improved.

  5. Thought I’d also write a little mini review here. This blog post convinced me to try Mk 677. I’ll admit after I had made my purchase I had thoughts of whether Derek had overhyped this stuff, however I can say that after 2 weeks of use, my original expectations have been met and maybe even exceeded. This stuff is the real deal! Here are some of my results after 2 weeks use

    * Gained 15 lbs (yes this is probably largely water, and additionally I am already tall and large so think about it proportionally)
    * Increased strength. Most of my lifts are up about 25%, but for some reason my shoulder press is up literally 50%! Insane
    * Less time needed for rest in between sets and ability to do more sets
    * Very little muscular soreness, and the feeling of recovering from workouts very quickly (feel like I can hit the same body parts hard 2x week rather than 1)
    * Improved sleep with vivid dreams. also on days where I have not gotten enough sleep it hasn’t affected me as negatively is it normally would.
    * Improvement in complexion, skin is clearer and more supple
    * Improved mood
    * Joints feel much better when lifting
    * Bigger pumps

    As far as negative side effects go the first week and a half use my appetite was through the roof and additionally I was a little bit lethargic, however these two side effects are largely gone now after 2 weeks.

    To anyone who is on the fence about the stuff I’d highly recommend trying it!

  6. Yo Derek, I’ve been looking into SARMS for awhile, but 1 thing I’m a little confused about is there are liquid and pill forms. I heard the liquid is better, but they’re just too damn expensive compared to the pill form…. So can the pill forms work good also? Because I can’t afford the liquid kind I’ve seen. Thanks

    1. It is arguable whether the grain alcohol in liquids pulls more of the SARM into the blood stream via sublingual administration, it’s kind of just based on broscience and anecdotal logs, I have yet to see scientific proof of such a claim. With that being said, send me an email and I’ll see if your budget will align with the price of my personal research source.

      I research both a liquid and a pill source and they both work great, but I also know for a fact the quality of the raw powders they are both using. Other labs I couldn’t vouch for (liquid or pill) because I have no experience researching other sources as I have had no need to stray away from my 2 go to’s

  7. Besides the increase in water intake and ensuring less intake of sodium are their any recommended ways to lessen water retention? I have Red Supplements on the way but not certain if they play into the water retention.

    Also is morning or night recommended.

    Thanks for any insights!

    Tyler

    1. You could use a diuretic. I know guys who use prescribed dyazide every day to completely offset the water retention.

      Dosing MK-677 pre-bed is best imo as taking it in the morning can make you tired through the work day.

  8. Thanks. I don’t know if the bloat is due to the preamp I use (CREATINE makes me bloat bigtime), or if it’s the Mk 677.

    The appetite increase is no joke though. It’s very noticeable within the first few days.

      1. Michael Johnson

        Hi there.

        Beem reading about these and want to start a cycle on them instead of the hexarelin and ipam i am currently on. All the pinning is getting to me now and i travel daily with work so its becoming a problem. Not to mention the cost. Ive already got my Huperzine A to take half an hour before as i was doing that with the peptides. How much would a months supply of MK677 cost me? I want to cycle for a few months and see my results. How many weeks would you suggest before taking a break and would it be ok to take it 7 days a week as i read you dont desensitize like you do peptides such as hexarein.

        Finally i trust your source if it works for you. Do you have a discount code? I see other websites offering the discount code but not sure if i trust the source for the mk677. Every little helps as it was starting to rip a hole in my wallet on the peptides.

        Many thanks
        Mike

        1. The cost is dependent on how much you want to use, you’ll have to do some math. MK-677 has been run for over a year straight in studies with no issues, so it’s up to you how long you run it/how long of a break you take.

      2. Hey man, i contacted u about this but got no response so i wanna drop this in here.

        Cancer cell hyperplasia – how much of a concern is this for you? You claim to use this as part of your hair prevention regime, are you not worried?
        This would be my primary worry when using any hgh secretagogue.

  9. I’m hesitant to try this. Been debating about it cause I already have some wild vivid dreams, and sometimes they scare the shit out of me already haha. Sounds stupid but I don’t want to have a heart attack in my sleep from some of the crazy dreams. The two reviews from the other guys were great. Really digging your site man, so much valuable information.

  10. Hi Derek,

    Weird question but does the MK-677 cause any birth defects? My wife and I are trying to have a second child and she’s worried the MK-677 can cause damage to the baby. Can you help?

    1. None that I am aware of. I couldn’t say for certain though. I highly doubt it, and don’t see why it would.

  11. Brian Andersen

    Hi.

    I’ve been reading this post and watched the video a couple of times. I’m currently on mk 677 but I don’t get hungry or tired. There basically nothing to report. I’m afraid that the only thing I purchased was rice flour in a gelatine capsule.

    What are the odds that I got the right stuff?

    What’s your experiencesearch? I’m not on anything else. Just plain mk 677.

    1. I have no idea because I don’t know what source you got it from. If you notice nothing, no weight gain, no muscle fullness, no hunger, etc. then it’s probably bunk.

  12. I just ordered and took my first dose, and it tasted disgusting. However, I read you need to hold it in your mouth. Should I put the dose in a glass of water, or just man up and hold it under my tongue for a bit? Thank you

  13. Stacked MK (25) with Osta (20) (2 weeks earlier), and am 1 week in with both, My joints feel great (tore my acl x 2 and rad meniscus repaired x 2) Makes me feel like my joints were in my 20’s (in my 40’s), I need less sleep than normal, and my energy is only slightly lower. Lifts are already up. It works and works well (just the joint relief itself is worth it). I have run into one issue….. My sex drive is down…. I have heard it is rare but it happens. I’m wondering if my prolactin is rising while on (I have never really had issues with gyno or other during a cycle, even when cycling my drive was always moderate and was back 100% after PCT). I’m not dealing with any nipple pain, but just very low drive. To the point I have turned it down (unheard of with me, started about the 4th-5th day in). I don’t want to get blood drawn up if this is something that stabilizes. If it is unheard of than I will…. ever heard of this happening.. Maybe drop it down to 12.5 and see?

    1. Sorry I know this is not test related, my last draw had me at within norm-to high for age, as was free test.

    2. You could be experiencing slight testosterone suppression from the Osta, or some estrogen elevation. I would add in 1 capsule of RED-PCT to keep your Estrogen in the sweet spot and crank your test levels up to mitigate your sex drive issue. That does the trick for 99.9% of guys, and it is always a good idea to not only have it on hand for your actual PCT post-cycle, but to offset any SARM induced suppression issues on cycle.

  14. Excellent informative post! I just have one question… It’s my understanding that circulating GH is inversely proportionate to insulin. Learned about this while researching intermittent fasting. (please correct me if I’m wrong) So if MK increases appetite & you eat more, wouldn’t the increased insulin response suppress the the increased GH release or does MK cause GH release regardless of blood insulin levels?

    1. There are 12 pulses that occur intermittently throughout the day, and it’s the Ghrelin release that causes insane hunger, not the GH pulses in particular, so it is very unlikely that the few times you eat per day are going to perfectly coincide and clash with your GH pulsations from the MK-677 and blunt their effectiveness. Highly doubt you eat 12 times per day anyways lol.

  15. Quick question, in the initial studies, dosing MK-677 was done first thing in the morning on an empty stomach. Derek, why are you a proponent for dosing at bedtime? Have you noticed a difference?

    One last question, how long into the cycle should Huperzine A be administered? I’d believe the body wouldn’t release Somatostatin immediately.

    1. I’m not a proponent of it necessarily, I simply find that when I used it in the morning the lethargy would hit way harder during the work day which screws up my ability to get work done obviously. Taking it at night time I avoided this because I would sleep through that first hardcore wave of lethargy that comes shortly after dosing.

      Second question I have no idea, I can’t physically see your Somatostatin levels so that would be impossible for me to answer. It’s a cheap supplement that has other mental and health benefits so I just run it the whole time.

  16. Thanks Derek for the Huperzine A tip, I did a bit of research on it and MK-677. I never told you this but I do posses a PhD in molecular biophysics and am currently a professor at a large So. Fl. University. ( Keeping it a bit anonymous.) It seems though, from the journals I pulled, a significantly greater growth hormone response was achieved at 50 mg doses vs 10 mg doses.

    ‘After treatment with 10 mg MK-677, IGF-I concentrations increased 52 +/- 20% (65 +/- 6 to 99 +/- 9 micrograms/L, geometric mean +/- intrasubject SE, P < or = 0.05 vs. baseline), and 24 h mean GH concentrations increased 79 +/- 19% (0.14 +/- 0.01 to 0.26 +/- 0.02 microgram/L, P < or = 0.05 vs. baseline). Following treatment with 50 mg MK-677, IGF-I concentrations increased 79 +/- 9% (84 +/- 3 to 150 +/- 6 micrograms/L, P < or = 0.05 vs. baseline) and 24-h mean GH concentrations increased 82 +/- 29% (0.21 +/- 0.02 to 0.39 +/- 0.04 microgram/L, P < or = 0.05 vs. baseline), respectively. Serum IGF binding protein-3 concentrations increased with both 10 mg (1.2 +/- 0.1 to 1.7 +/- 0.1 micrograms/L, P < or = 0.05) and 50 mg MK-677 (1.7 +/- 0.1 to 2.2 +/- 0.2 micrograms/L, P < or = 0.05).' [1] J Clin Endocrinol Metab. 1997 Oct;82(10):3455-63.
    Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.
    Chapman IM1, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO.

    I'm experimenting with 25 mg dosing BID. With obese subjects at 25 mg dosing the results can be obtained here: http://www.ncbi.nlm.nih.gov/pubmed/9467542

    There's a lot of info out there, Your reader can Google Scholar many articles. Thanks Derek for your tip.

    1. Actually, 50mg doesn’t result in much higher GH concentrations than 10mg, but it did result in significantly higher IGF-1 concentrations. There is a big difference between the function of high GH levels and high IGF-1 levels.

      High GH levels typically equate to more fat loss, whilst high IGF-1 levels equate to more muscle growth.

      So, based on the study, if fat loss and the anti-aging/healing benefits of HGH is all that is sought after by the user, a 10mg dose would likely be sufficient. Whereas if the user was seeking maximized muscle growth potential, then higher IGF-1 levels would be what they are after, and would then justify a higher dosing protocol. 50mg is unnecessary imo, 25mg is standard for getting IGF-1 levels significantly higher, and reaping all of the benefits of the GH still.

      1. Michael Johnson

        Hi mate. How do i get 25mg when the doses are only 10mg each? Would 20mg (2 pills) for the above answer suffice. Or would i have to go with 3 pills a day (30mg) would work out hella expensive that way. Im hoping i can make good muscle gains on just 10mg 1 pill a day before i go to sleep. What do you think my chances are? More than 1 pill a day will prove costly for me.

        Many thanks
        Mike

  17. Hey Derek. I was wondering if it possible to take mk-677 after the last week of YOUR PCT for A.A.S. as you may know it can be brutal and tiring, but I ordered the mk and haven’t used it yet,but my main concern is will it bring back some of the muscle lost during n after PCT and most of it water weight? It says it is good for the heart and kidneys is this a fact? Also, what about the liver (using liquid form mk 677)? Lastly, I plan on using it daily for the next 2-3 months alone, then stopping before I do another cycle of sauce..I know it does not suppress test but does cause a massive increase in strength hunger etc, but in the beginning article says no pct necessary for the mk677,u just mean of “stacked ” with other sams (bc of suppressio) correct? Sorry one more thing lol if it makes you feEl lethargic and tired even after sleep hoe does it improve sense of well being and mood? In all honesty if taking 25mg daily for a month or 2 will you realistically see positive changes to the mind and body and it claims to put on lean mass (I know diet plays a role) but if so much water retention is this capable and as soon as u stop it, does it effrct you internally as well as mentally….depression, lack of sex drive, more lethargic…sorry for longgg post but do the best you can please lol. Thanks

    1. Holy Jesus that’s a lot of questions 😛

      1) Yes it is great for retaining gains post-cycle
      2) It isn’t bad for heart or kidneys if blood pressure is kept in check
      3) It doesn’t suppress your endocrine system no
      4) Don’t understand your question. HGH improves quality of life, so does MK-677. Start thinking about MK-677 just like HGH and then before you ask a question ask yourself how would HGH do _______? The answer is the same for both, because MK-677 simply cranks your HGH production up.

  18. I like your site, but there’s one thing you could improve; the color of the text. Right now the light gray text is really hard to read against the white background. I think it’d be easier to read, and attract more readers, if you made it a little bit darker.

    Cheers

    1. It used to be black, but when i updated my theme the font got thrown off. I’ll look into getting the font colors changed back to black once when I’m up tomorrow. I hate the light grey too lol.

  19. Thanks for the excellent and informative information. I was curious how well this stacks with an AAS stack (test/tren/var) and to continue running it through PCT to minimize loss of gains. I see it works well for PCT but didn’t see any detailed info on benefits during cycle. I’ve never run HGH due to above stated reasons and the hassle of pinning my gut numerous a day.

    1. The amount of exogenous high quality GH that would be needed to run to cause notable organ growth is out of the price range of 99% of individuals. MK-677 won’t get your HGH/IGF-1 levels high enough to cause organ growth.

  20. If I already take medication that helps me sleep at night would it be a good idea to take the mk 677 and my medication the same time? I am mostly wanting to take this for the increase in appetite and growth of course so I’ve read if that’s the goal then it would be better to take it during the day be fore breakfast and dinner?

    1. It makes zero difference results wise what time of day you take it, the 12 pulses it makes will occur over the next 24 hours regardless, it doesn’t surge all at once. It wouldn’t be a good or a bad idea because I don’t know if you would rather be more tired or not after taking it.

      I’m guessing if you take sleep meds you would welcome something that makes you sleep even easier so maybe try them together, it could make you sleep easier and deeper. Some individuals have the opposite reaction though and it keeps them awake, so in that scenario switch dosing to morning upon waking.

    1. Depends how shitty your diet is. If you abuse the hell out of carbs and are fat then yes. If you are in shape, lean, and keep a balanced diet almost undoubtedly no. You should be more worried about insulin resistance from food you’re eating and your body composition than MK-677 which will have a negligible effect on insulin resistance.

      Read this study on it.

      “Favorable changes in body composition because of MK-677-induced increases in GH secretion could conceivably counteract any unfavorable effects on insulin resistance. GH therapy in GH-deficient subjects has been reported to increase insulin resistance at 6 weeks, but have a diminished effect at 26 weeks when significant decreases of body fat have occurred”

      Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults

  21. Hey Derek. I was interested in MK-677 and wanted to try it but I’m only 16 years old and didn’t know if that is too young and what, if any problems I would have?

      1. Yeah, solid advice. Bro, why would you think about using anything but eating good food and training hard till your 20’s youll grow and grow… I was gaining 20lb a year from 15 to 20. I went from 98lb to 205lb naturally. Can’t say it was all muscle but i could easily hit 330 on bench.

  22. Naturally Skinny Guy

    Derek, I want to thank you for this excellent recommendation. It’s been a little over a week and I’m up 5 pounds. It doesn’t sound like a lot, but with my height/frame it’s much more than I expected. I look visibly bigger in the mirror, and haven’t lost any definition. I’m also sleeping better than I ever have before, and I’m way hungrier than ever before.

    I think mk-677 is amazing for naturally skinny people who’ve had abs their entire life, but never had the muscle mass to look great. Try it, you won’t regret it,

  23. Just had some questions regarding high and MK 677. Is it safe to stack them? Currently on 6iu ED and definitely seeing the results. If I do 3iu am, 3iu mid day/early evening, and take the MK677 before bed, that should be safe, correct?

  24. Just bought a bottle from the company you recommended. As a “bare-bones” protocol, could I just do 20mgs mk677 for 4 weeks or do 10mgs for 8 weeks? The Enhanced Athlete has 60 capsules. I just intend to use mk677 as a standalone because of finances. However, is it necessary for a post cylcle?
    Thanks for any suggestions.

    Sam

    1. 4 weeks of 20mg isn’t a good cycle, and neither is 10mg for 8 weeks imo.

      This is a product that works better for the longer it is used as HGH and IGF-1 levels build in the body, it isn’t something you can use for 4 weeks and gain a huge amount of permanent muscle.

      Don’t understand your second question. Are you asking does it need a PCT? I answered that in my article.

  25. Hello,

    I recently purchased MK 677. I regularly go to the gym and and have always struggle in gaining weight. I know MK 677 can help me with that .. but the reason I bought it is to increase height. So my question is that can I still go to the gym 7 times per week and expect the height increase or does the extra gh get spent on increasing muscle. I want to gain height instead of muscle so….I don’t mind doing cardio every day instead if it would help the mk 677 grow taller.

    Mk677 has been used on growth deficient children and it has been seen as applicable short term. https://www.ncbi.nlm.nih.gov/pubmed/11452249

    Help please. Would 8 weeks be enough or would I have to get in long term? Also I have seen mixed details about its effectiveness over prolonged use … like some say the 24h level IGF decreases, while some say it remains the same as you first started it.

    Would appreciate your answer on this,

  26. 1 – where can I directly inquire about MK-677?
    2 – I’m getting the one in capsule form. At 25mg a day how long does a bottle last?
    3 – is MK-677 enough to help gain mass or I have to stack it with another product?
    4 – I’m from philippines, do you guys have any experience about shipping here? I’m not sure about our regulation and restriction regarding these kind of products.

    1. 1. You can inquire about it right here, what do you want to know?
      2. I don’t know what your source is or how many comes in the bottle, so how could I possibly tell you that?
      3. If your diet and training is in check then it’s fine on its’ own for making substantial progress.
      4. I’ve never been to the Philippines or tried shipping anything there so I’m not sure you’d have to look into that yourself.

  27. Hi i just bought mk 677 from newroids.com. The bottle says its from dn a anobolics. I have been taking it for 7 days. O noticed no increase hunger or sleepiness people say they get. Can you tell me if you think its fake. And should i try enhanced athletes? Im pist i dont think its working.

      1. ok, I’m going to follow the bulking cycle in this article. So that’s lgd-4033, mk667, and armi.

        My question is, should I stop taking my testosterone boosters like tribulus and zma?

        1. Tribulus and ZMA are negligible additions to the Arimistane. Up to you ultimately, but they won’t make much of a difference.

  28. Can I give this to my dog? She’s 12 & has partial ACL/PCL tears & arthritis. I’ve tried laser therapy, glucosamine, chondrontin, CBD, etc. The vet didn’t want to do surgery because of her age. She’s about 55 pounds & it breaks my heart to see her moving around like she does. She’s in good health otherwise & a happy dog.

    1. It’s a research chemical not intended for consumption by anyone. I have no idea if you can give it to your dog, or if the chemical would work the same in a dog as it would a human. You may be the first “researcher” to find out though.

  29. Hi man i was just wondering if i can take mk 677 by itself for a month and how will i cycle off it and will i lose gains or feel different when i stop taking it

    1. It does the exact same thing in females as it does males. In one of the comment sections of one of my MK-677 articles, there is a woman who posted a very positive review as well,

  30. I’ve watch a lot of videos on mk677 and was wondering if the major water retention is just at the beginning or does it last as long as you’re on it?

  31. Hello I was just wandering how mk677 will affect my chances of having kids.im 34 and I want to try a mk677 only cycle for 3 months but I want to try for kids at the same time.will mk677 cylcle only affect my sperm.Thank you

  32. Hey man … I’m running test e at 250mgs per week. About to begin MK 677 with this at 25mg per day.

    Do you have any experience of running the two together?

    Many Thanks

  33. Man this stuff sure sounds great. What are the odds that it gets pulled from the shelf any time soon? Where would I go to get a heads up on such information, so that I could buy before its banned?

  34. Hi Derek,

    Since this releases GH and IGF-1 will it help with cartilage damage? I have read that GH can help regrow damaged cartilage.

    Also, when you cycle off after 12 weeks, how long do you wait to restart again 6 months? 12 months?

    Any negative effects on hair loss, etc?

    Thanks

    Adam

    1. If that is one of the benefits of GH then it would also be one of the benefits of MK-677.

      Completely up to you, this is a research chemical. The pituitary gland doesn’t need to recover to produce GH like the endocrine system does to produce testosterone, so time off isn’t as much of a necessity, and ultimately it is up to the user what they decide is adequate.

  35. Makes sense. I know you recommend cycling it. How many cycles do you do in a year if you don’t mind me asking?

    And you haven’t seen any negative side effects from using this in the past?

  36. I am about to start 10 mg/day of EA MK-677 and hope to ramp up to 25 mg/ day. I wanted to get your opinion on whether stacking Ostarine from EA with that would be effective. Looking to drop some weight and add lean mass, workout 4x week and am over 40 and been working out since back in the day and fighting the aging process. Thanks.

    1. Yes it’d be effective.

      However, your goals are totally contradictory and you aren’t going to have much success dropping fat and adding muscle at the exact same time. Pick one goal or the other and do it properly is my suggestion.

      At your age, I’d go get blood work done and see if you qualify for TRT. The last thing I’d be doing is cycling suppressive SARMs at over 40 years old.

    1. You can take it with whatever you want or as little as you want dude. It’s up to you based on your goals and what you’re willing to do.

  37. Hi, there
    I dont currently work out and i am going to follow a workout plan and clean up my diet. I was wondering theoretically would mk 677 still have a positive affect on me if i was just to diet, with no diet. Once again i will be working out if i decide to purchase this but i was just wondering.
    Thanks, hopefully i can refer to you if i have any more questions

    1. If you were “just to diet, with no diet”?

      I’m not 100% what you mean by that to be honest man, but yes GH has a wide array of benefits that are above and beyond just basic bodybuilding application. It would help regardless of what you’re doing lifestyle wise, you would simply be hindering your potential results by not applying a proper diet and/or training regimen.

      Hope that answers your question.

  38. I was only planning on researching 25 mg a day for just a month, as I am experimenting with an alternating routine of 1-month bulking, 1-month cutting, and so on. Would it be better to continue the MK longer than one month, though? Would it help with muscle retention while cutting?

    1. If you’re looking for the appetite stimulating benefits, quick boost in fullness, joint lubrication and strength, then ya just using it for a month is fine. If you are looking to get the true benefits of HGH/IGF-1 (hyperplasia) then no 1 month won’t do much for you.

      Yes it helps retain muscle in a deficit.

  39. Hi Derek,
    Great site! I’m 49-years old, 202-lbs at 25% bodyfat. My goals are to lose weight, reduce bodyfat, and obtain anti-aging benefits. Base on your response, it seems like MK-677 (continue to do this year round), RAD-140, and Cardarine would be optimal for those goals. What protocol/dosages would be optimal to achieve my goals? I workout and my diet is not too bad (just lost about 20-lbs in the last six months).

    Thanks.

    1. Have you had your testosterone levels checked? At 49 years old, you likely have subpar levels (they start declining once you hit 30 years old and steadily decline for the rest of your life). You would get everything you want and more (probably) by simply getting on TRT and getting your levels back up to where they used to be (when you were in your early 20’s and peaking).

      MK-677 and Cardarine will help a lot too yes, I would advise against RAD140 though at your age as it is suppressive unless you were on TRT, as suppressing an already subpar level of testosterone is usually a recipe for disaster.

      1. I have not checked my testosterone levels yet. I’m scheduled to do it next week with the rest of my blood work to see if I should be on TRT. So if I am prescribed TRT then would you recommend RAD140 as well? Or just stick to the TRT?

        Thanks.

        1. Stick to TRT until you know how you respond to it, then consider adding in RAD140 if you want after that. You need to know how your body responds to one thing at a time ideally before you start combining things.

    1. I think that if it worries you you should cycle off periodically once and a while. I definitely wouldn’t do eod or e3d dosing though. Personally, I’ve already looked over it and it doesn’t worry me one bit.

      1. Could you please explain why it doesnt worry you exactly? I dont have enough knowledge in the subject to dispute their claims. Like why dont think mk677 with its long half like and chronic ghrelin stimulation will cause the negative effects stated in the article. Thanks for your time

        1. Throughout the study, sentences are started like “It is not clear why” such and such thing occurs. I have never experienced “fear” or “anxiety” from MK-677, or mental degradation of any capacity, and neither has anybody I know who has run it for a long time. The supposed side effect has never once occurred in real life use that I’ve known of, and this study is proposing findings based on things that are “not clear why” they are even happening.

          Not to mention that this is the only article on the internet talking about this whatsoever, and other clinical studies have found MK-677 to have contradictory effects.

          One forum poster in that thread summarized it pretty well:

          “After combing through with friends, here’s the response:
          1 The “study” is based on projection not tests.
          2 The tests that were quoted were not done with MK677, so again the “study” projects the results on to MK677 (which would also imply that MK677 does what it claims).
          3. The sum of the “results” quoted as being negative was not reported by people currently using MK677, and quite the opposite: nothing but positive results when dosed properly. ESPECIALLY cognitive function.
          Conclusion (so far): makes one project a financial or underlying motive against MK677 to possibly get funding to test a NEW compound which will be projected as “Safe & Effective”.”

          1. Appreciate the explanation man, that definitely makes sense. I myself after running it for a little over 2 months have actually felt like my anxiety has been a bit less and well being slightly better so i am with you and the other users experiences on that one.

  40. Stupid question. The caps supplied by EA are 10mg. How did you get a 25mg dosing? Are you breaking the caps open?

      1. I am researching the liquid from EC now. I think its been a little over a week and I am not sure I am getting any noticeable effect off of 20mg/1ml. Should I up the dosage? I am going to start the Huperzine today.

        1. I’m not in a position to tell you what you should or shouldn’t do. I’d run no less than 25mg but that’s me personally.

          1. Fair enough. Its just that you said you felt the effect within a few days. I hope I didn’t get a bottle of Benedryl. I think my appetite has increased, but I feel like that is bad, because I am craving bad food. Any other tips for how to take it, like calorie intake? Maybe I need to get on test therapy as a #1 prio, as you recommended to someone else in their 40’s.

  41. Hey Derek I’m on Trt currently I’ve dieted down in the last year and half and lost nearly 50lbs currently at 202lbs changed my body comp completel (8.9% BF) my problem is at 48yrs old I can’t seem to tighten up that lower tear of my abs? I recently purchased MK-677 will this do the trick? My diet has been on point and I’ve even had to put a cheat day in to hold fullness due to low carbs! Any advice would be appreciated!

    1. When you say “tighten up” do you mean there is fat still there to lose, or it just looks like loose skin?

      And no MK-677 will make you hungry as hell and you will more than likely overeat past your calorie restriction requirements necessary to lose more fat. This is why I never advise using MK-677 during a cut, and especially not introducing it for the first time during a cut, as the hunger response is always the most intense when you first start it.

      1. Actually Derek , the hunger does not effect me I’ve been in a low carb state for a year and a half went from 24% body fat to 8.9% I used the keto diet with a refeed! After 2 weeks at 20mg I’m sleeping well yes the hunger is up but I still limit my carbs and feel awesome. I think the sluggishness is what gets me! Now back to my original questions my stomach is tight it’s just that last bit of subcutaneous fat I struggle with! Overall this stuff has worked well for me even after 2 weeks! I will run it at 20mg for 6months. Thanks not sure if that’s enough info for you lol!

        1. If you can actually stay within your calorie allotment then yes it will help burn more fat. Most people typically overeat on it though.

        1. Mk677 hands down man. I’ve had some joint/back pain at times from lifting too aggressively, and a course completely reversed it. I’ve cut myself working construction, and seen the skin heal much faster.

  42. I’ve read that Serms lower gh production, which I’ve seen (25mg mk677 while on tamoxifen did nothing for me). Raloxifene has shown lower effect on igf. So would mk during ralox be a waste? Plus, would the mk slow gyno reduction even if it’s estrogen-depleted?
    Thanks for the great resources man!

  43. Hey Derek,
    I want to run MK-677 along with lgd and rad for 12 weeks. I noticed on some of your posts you only advise taking arimistane for pct while in other places you’d recommend a full Clomid Nolvadex and arimistane. What would be your thoughts on pct for that cycle? Also, would you recommend 25 mgs arimistane during the cycle? Thanks!

  44. Anirban Banerjee

    While dosing the mk 677 prebed, isn’t there a chance that you wake up middle of the night due to hunger? And also, what’s the ideal diet while on mk?

  45. Yo derek im thinking starting a cycle of mk677 alot people are saying it needs be run for 6 months to see results ? Im going run it for 3 months i got me brothers wedding coming in april i want look a bit jacked up in a suit i was wondering cause its me first ever cycle what can i expect i know you said u gain 10lbs water weight in couple weeks but im looking to gain muscle i know u cant stop the water weight but what kind of muscle gains can i expect to see in few months on this lbs wise ? If me diet and traning was bang on thanks bro

      1. thats fair play bro what do u reckon if i stacked this with sr9009 and lexogenin im trying stay away from supppressive sarms is that a good stack ? thanks

          1. whats your take on gw to build muscle ? im going stack gw with mk677 what do u think about this stack thanks bro

  46. Thanks bro apperciate your time couple quick questions ? What about sr9009 ? U reckon that better than gw ? Also alot people are saying mk677 is inuslin senstivity or something i dont get that ? What does that mean i have need2slin nutrion pationer would this make a difference taking this with mk677 to keep insulin at bay ? Also im thinking running mk677 for 4 months then cycle off for a month is that alright ? Thanks bro

    1. GW is much better than SR9009 in my opinion. You need to be more specific about your question regarding MK-677. You can cycle off as often or as little as you want, there is no rule book for this compound, it is a research chemical at the end of the day.

      1. Sorry what i meant was alot people are saying mk677 and something about it messing with your insulin levels what does that mean ? Also theres youtuber goes by the name off 44 swole he said mk677 raises prolactin levels 6-7% therefor decreasing testosterone ? Which he pulled a study up from ncbi some study site which does studies ? Whats your take on that thanks for your time bruva

        1. It increases your blood sugar which can increase insulin resistance if left unchecked for a long span of time. Ya there is a connection between increased GH levels and prolactin. And there is also a connection between increased prolactin reducing Testosterone levels. If it were the case that the amount it hindered you was so significant that it severely hindered your progress then there would be no natural competitors using GH though, so I feel like that’s just looking for problems with the compound at that point. Greatly increased GH and IGF-1 levels will outweigh negligibly suppressed Testosterone levels (if it even occurred), otherwise there would be no point of taking anything GH related unless you were on gear.

          1. Thanks derek been really helpful bruv that sums it up what can i do to keep insulin at bay ? Im going run mk677 from january till april time then take a month off then back on again ? Thanks man appericiate your time and effort

          2. That’s up to you there is no set in stone way to go about researching it. There are many ways to stay insulin sensitive, just do a quick google search. Limit carb intake, don’t eat sugar, do cardio, + more. There are lots of things you can do.

  47. i’ve heard some things about hgh causing enlarged organs. is that just on high doses? or is mk677 much different than hgh in that regard?

  48. Any difference from this MK-677 from EA versus the MK-677 from Enhanced RX?
    Just curious if you have had any experience, opinions or otherwise.

    1. It should be the same raws used in both so the quality shouldn’t differ. I haven’t used the RX tabs though to try and compare.

    1. Not important at all. It just stimulates faster hair growth. Does nothing for prevention at all as it has no effect on androgens.

  49. Hi Derek,

    Can I take MK-677 while on Finasteride?

    What I mean by this is would Finasteride lessen the efficacy of MK at all (or vice versa)? And would being on the two compounds simultaneously cause any potential adverse reactions?

    Thanks in advance,

  50. Hey Derek,
    Amazing site and especially the time you’ve taken to answer questions in the comments. I’m 51, in decent shape but not a body-builder, workout 3 times a week, body-fat 19%, etc. Mostly interested in general health, anti-aging and staying young as long as possible. 🙂 MK-677 looks amazing and i’m considering adding it to my supplement regime.

    Any info, links or such you’d have for someone like me?

    Frank

  51. This was great information! Very informative. I am 54 years old and have been bodybuilding (and other sports) since I was 12. As I get older it is increasingly difficult to maintain strength and muscle growth. I’ll need to look into this MK-677. Thank you for posting and maintaining this site.

  52. Hi Derek!

    I’m looking for the sleeping benefits from the MK-677 (I suffer the middle-of-the-night type of insomnia, wake up often during the night). I’ve read some people claiming taking MK-677 worsened their sleep instead of improving it.

    I’m a little confused about this.. Also, what would be the optimal timing/dosage for this goal?

    Many thanks man!

  53. hey derek, i made this same comment with another email but i’m not sure if it went through so i’m asking again just in case

    when i take my mk solution/liquid sublingually i can’t tell if it’s actually absorbing or not. is the liquid actually supposed to disappear? or does it get absorbed after a couple minutes then i swallow whatever is left?

    1. Sublingual administration of anything doesn’t require absorption of the liquid. I don’t even thing it really makes a difference (sublingual vs not) anyways to be honest.

  54. thank you for your work on SARMS, its the best ive ever tracked down.

    im coming off a 12 week RAD-140 cycle from PPs. i always use you code and thank you for that!!

    MY QUESTION – is MK 677 ok to run during your PCT? Waste of time? not as effective? better to run on cycle?

    im running 40mg of nolvi and 20mg of clomid, but id like to have that extra benefit of MK 677 to help me during the PCT.

    SECOND QUESTION – do u need to run an AI if youre running nolvi and clomid?

    the first time i came off rad 140, didnt have a good PCT ready and got SLIGHT gyno in one pec but the AI took it away quickly.

    – thank you again for your work on this site

    1. MK-677 isn’t suppressive, it has nothing to do with endocrine function at all, so when you use it is irrelevant to your endocrine recovery, so ultimately it’s up to you. It works exactly the same regardless of when it is used.

      Depends what your Estrogen levels are at.

  55. Hey Derek I know you’re busy didn’t get a chance to see your response to my question. I have the MK 677 at 10 mg each would you recommend taking 30 mg or 20 mg daily

  56. Hi Derek, great article. Question regarding the hair density gains, after cycling off, can we expect to shed the hair we gained?

    1. You don’t grow new hair with Ibutamoren, it just seems to drastically improve the growth rate, which indirectly equates to more density.

  57. Derek,

    Very informative article…thank you.Had a couple of questions.First,it seems like the sweet spot is 25 mg. a day.Was looking at Narrow Labs,and their pills are 10 mg. each.Would you say that there is much difference between dropping 5 mg. and going with 20 a day or adding 5 and going with 30?Second question…I have a pretty physically demanding job,is there any supplement you recommend that can help reduce the lethargy that comes with MK usage?Look forward to your reply and thanks again.

    Best,
    Jason

      1. Hi Derek, started with Ciccone mk-677. The hunger is no joke and I feel good energy. But, I feel that I can’t focus. It feels that I can’t even sit on my chair and write an email. Feeling very hyper active.

        Is this common side effect?

  58. Hi will Ibutamoren (MK-677) work on a 43 year old male who is trying to gain 5-10 pound in lean muscle mass ???

    I have Hit a plateau and neither can I get my calorie surplus nor getting the result I want on my power lifting.

    1. MK-677 won’t add 10 pounds of lean muscle mass. I’d advise getting a blood test to see if you are Testosterone deficient or IGF-1 deficient before you decide what you want to use.

  59. I asked because you recommend 4 brands and I was wondering which of them do you actually use. And really could not find the info regarding liquid vs. pills.

  60. Hey Derek,
    I’m turning 20 next week and been training for 2 year. I only hit puberty when I was 18 so I’m still peakin through puberty at the moment. My start weight was 52kg at 6foot and I’m 84kg at 6.2 atm. My question is do you think it would be safe or run mk667 now or wait? I had a blood test recently and they doctor said I had perfect result. I’m care a lot about my health which is why I don’t want to touch Sarms or any anobolics. I’ve only heard good things about mk667 though so I’m really considering it. Thank you for your advice 🙂

  61. Hey Derek
    im currently 18 years old and had a shoulder reconstruction in november. Iv lost alot of muscle and also put on fat around the stomach area. Would you recommend taking Mk-677 at 18 and would it also help in recovering from my injury, Would Mk-677 help in aiding in muscle growth and fat loss? Cheers

    1. I think you’ll end up overeating if your goal is fat loss, and if you are already at too high of a body fat % I wouldn’t advise using a ghrelin mimetic at all.

  62. Hey Derek,

    Great, well written articles.
    I have a few questions regarding a SARM stack. Firstly, do you know of the quality of the IRC.bio SARMs? Their site is closed but the products are still available wholesale.

    I am planning on running an MK677, cardarine, and LGD 4033 stack.

    I read that cardarine doesn’t necessarily have to be cycled, but I will probably run it for 12 weeks (10mg daily) along with the LGD 4033 (5mg daily).
    The MK677 I will run about 8 weeks (25 mg daily).

    If I am newer to SARMs, would you consider this stack to be reasonable?

    Also, I hope to use ashwagandha and n-acetylcysteine for PCT. The ashwagandha to boost T and the n-acetylceistine to regulate liver enzymes. Thoughts on this?

    Thanks!

    1. Hey man I’m 21 years old and recently ran a cycle of rad 140 30mga nd lgd 10mg a day. I did that for my first cycle ever and probably shouldn’t have done those high dosage and got very suppressive from it and starting losing much of hair. Didn’t do a pct either because the source I got it from now said I didn’t need one. Ita been about 6 weeks since the last time I took anything. I have mutant test boosters. Is it to late to run a pct? Also I ordered a stack of mk677 and mk2866 ostarine. Gonna start taking mk677 in few days at low dosage for first week 12.5mg then add the ostarine in at 15mg for next week and see how body reacts then might bump up to 25mg of mk677 and 30mg of ostarine. I have a bottle of estrogen blocker. And should I run a pct after this? Sorry for all the questions. Idk if my testosterone is back to normal still or what I just know my sex drive is normal and my hair thinning stopped completely. I know its alot man but what do you recommend for all this crazy information haha

  63. On MK-677 from Narrow Labs for 9.5 days. 10mg’s morning and eve, for 20mg total/day. Side effects began yesterday, but very bad today and I will be stopping the regimen. Dizzy, nauseous, blurred/dark/tunnel vision, difficulty concentrating.

    I’m 45, approx 13%BF. Had hoped this would help with nagging injuries from 30-yrs lifting. Never taken anything other than regular supplements before. It hasn’t helped the nagging injuries thus far. I did notice an increase in appetite, and put on approx 8lbs, but assume it is basically all water.

    Felt 10 yrs younger almost immediately (which you won’t understand unless you’re older), but side effects outweighing benefits. Might give it a couple of weeks and try cycling it for 1 wk on, variable off, assuming side effects go away relatively immediately given the half life is so short.

    Any insights appreciated. Thanks.

    1. Update: I was just dehydrated – blood sugar was fine – thought I could eat and drink like normal but not the case. Drank a ton yesterday and today and side effects gone. Sticking with it!

  64. Hi Derek,

    Do you know how much of an effect huperzine a actually made on igf-1 levels when taking it with mk677 vs not taking it, have you see any blood test results either from your own blood tests or anyone else on a forum showing how many points difference it actually made?

    Thanks,
    Ronald

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