How To Replicate A HIGH Dose Of Pharma Grade GH With MK-677 And Peptides

So you probably already know how MK-677 on its’ own can replicate a modest dose of high quality GH (Growth Hormone).

Mk-677 has a level of diminishing returns (once you pass 25mg per day), and it cannot replicate a very high dose of pharma grade GH no matter how much MK-677 you take.

However, there is something you can add in that will potentiate each MK-677 GH pulse to an extreme degree.

So much so that it will drive IGF-1 levels up to match that of a HIGH dose of pharma grade GH.

(If you haven’t heard of MK-677 then I suggest you go checkout my articles and videos I made about it in 2016/2017 first).

That addition is CJC-1295 DAC.

Also commonly referred to as CJC-1295 With DAC.

CJC-1295 DAC is what I combined with MK-677 when I was younger (and cared a lot more about getting as big as possible) to replicate the IGF-1 levels that pharma GH yield, without having to go out and try and source pharma GH or pay the absurd price tag for it.

If you don’t already know of all of the benefits of elevated HGH and IGF-1 levels, I wrote out a comprehensive list of them in my MK-677 overview article that you can check out.

CJC-1295 DAC

CJC-1295 DAC is a potent Growth Hormone Releasing Hormone (GHRH).

Do not get CJC-1295 DAC confused with Modified GRF (1-29) often abbreviated as Mod GRF (1-29), and also often referred to as CJC-1295 No DAC which needs to be shot multiple times per day with a GHRP to achieve a substantial benefit.

It’s important that you know the difference as Mod GRF 1-29 is absolutely useless to use with MK-677 as you can’t manually match the pulses of MK-677 to the active life of the Mod GRF 1-29.

CJC-1295 DAC is a modified version of the first 29 amino acids of Growth Hormone Releasing Hormone, together with addition of a “Drug Affinity Complex” (referred to as DAC).

The combination of modifications and the addition of “DAC” provide a half-life of about 1 week, and steady blood levels after it is injected.

While the mechanism of action behind MK-677’s ability to increase GH and IGF-1 levels is the stimulation of the Pituitary Gland to pulse out 12 very strong pulses of GH over the course of every 24 hours, the mechanism of action behind the GH/IGF-1 boosting effects of CJC-1295 DAC are quite different.

CJC-1295 DAC results in a bleed of GH to be released over a longer span of time.

It doesn’t stimulate short, strong burst-like pulses like Mod GRF 1-29 couples with other pulsatile GHRP’s do, rather, it simply amplifies the potential of the current pulses occurring in your body via this slow GH bleed effect, making them more effective and raising HGH/IGF-1 levels to a much greater level.

Because CJC-1295 DAC has a long half-life, it produces a GH bleed effect, where the strength of every single GH pulse that occurs during that span of time that the CJC-1295 DAC is in your system is amplified several fold.

Now, on its own, CJC-1295 DAC isn’t overly helpful when it comes to muscle building potential.

But, combining MK-677 (which is a potent GH Secretagogue that results in several new and strong GH pulses in the body) with CJC-1295 DAC (which provides an amplifying GH bleed effect) results in a 1 + 1 = 3 type of results.

By that I mean that by combining the two, they work synergistically to provide benefits that would otherwise be impossible to achieve with each compound used on their own separately.

CJC-1295 DAC amplifies the strength of the MK-677 pulses essentially, resulting in sky-high HGH/IGF-1 levels.

Mod GRF 1-29 Vs CJC-1295 DAC For Building Muscle

Now, there are arguments in the bodybuilding world about why a GH bleed is bad, as it doesn’t match the natural pulsatile fashion of real growth hormone pulses from the pituitary gland, and strong GH pulses are what are necessary to constantly have throughout the day to build copious amounts of new muscle yada yada yada.

At the end of the day, the fact remains that GH DOES NOT build muscle well, rather the pathway to new growth via GH use is completed with the constant systemic elevation of IGF-1 levels in the body that multiple daily shots of synthetic GH accomplish once they are converted in the liver.

So, to get the muscle building effects that we want from GH, we need our IGF-1 levels cranked through the roof.

Well, it just so happens that although CJC-1295 DAC doesn’t cause multiple short GH pulses like the human body is programmed to do, rather, its’ GH bleed results in a modest elevated GH serum and IGF-1 level around the clock.

And when combined with MK-677, which acts 24 hours around the clock self-pulsing GHRP in itself (and a GHRH in some capacity as well), IGF-1 levels can get extremely high and stay extremely high for long durations of time.

This = huge muscle growth potential

High levels of GH = minimal muscle growth

High levels of IGF-1 = greatly increased muscle growth potential

If you want to make the most of whatever GH related enhancements you are going after, keeping IGF-1 levels elevated for as long as you can each day is the key to maximizing your progress.

Pulsing Peptide Protocol Vs Peptide Induced GH Bleed Protocol

With a standard pulsing protocol with Mod GRF 1-29 with a GHRP even shot 3x per day (the gold standard), you are achieving GH elevation for only 4.5 hours per day, and only 9 hours per day if you are hardcore and do 6x Mod GRF 1-29 + GHRP peptide shots per day around the clock.

With CJC-1295 DAC, you are getting a bleed resulting in elevated GH and IGF-1 levels 24 hours per day, along with MK-677’s 24 hour constant pulses, you are sustaining high dose pharma grade GH IGF-1 score levels all day long.

Here Is A Beginner’s MK-677 And CJC-1295 DAC Research Protocol:

2500mcg CJC-1295 DAC subQ inject before bed – Monday & Thursday (5000mcg – 5mg total per week)

25mg MK-677 before bed every day

200mcg HUPERZINE A taken 3x per day (600mcg total)

With this protocol, you can reach an IGF-1 level of about 500ng/mL. This is formidable to a very fair dose of pharma grade GH.

This is obviously dependent on several factors, as we know that IGF-1 depending on diet and amount of exercise performed in the last 24 hours will vary 10-15%.

It is also dependent on that individual’s genetic predisposed response to synthetic GH, GH peptides, and GH secretagogues of course.

This lGF-1 level should be more than enough for anybody who isn’t trying to compete at a professional bodybuilding level.

For the record, this is the protocol I used myself when I used to use CJC-1295 DAC with my MK-677.

Here Is A VERY Advanced MK-677 And CJC-1295 DAC Research Protocol:

With this protocol, IGF-1 levels will exceed, or at least match a HIGH dose of pharma grade GH:

3333.33-5000mcg CJC-1295 DAC subQ inject before bed – Monday, Wednesday, Saturday (10,000-15,000mcg – 10-15mg total per week)

25mg MK-677 before bed every day

200mcg HUPERZINE A taken 3x per day (600mcg total)

With this protocol, you can reach an IGF-1 level close to (or exceed) 700ng/mL.

Which is absurdly high, and shouldn’t even be necessary unless your goal in life is to compete at a high level.

The dosage for this protocol is a range because some individuals can achieve a much higher IGF-1 level than others with a lower dose, whereas some individuals need a higher dose to reach that same IGF-1 level.

Side Effects

The side effects from this protocol will parallel the same side effects you get from synthetic GH.

In addition, MK-677 specific side effects include increased hunger from increased Ghrelin, and CJC-1295 DAC specific side effects include facial flushing (doesn’t always occur) post injection.

If You Are Cutting

If you are cutting and wanted to utilize this kind of protocol to replicate a high dose of pharma grade GH but can’t handle the hunger induced by the Ghrelin spikes from the MK-677, then simply swapping it out for another GHRP that doesn’t spike Ghrelin levels would suffice.

CJC-1295 DAC works around the clock, so whatever GHRP you introduce will work several fold more effectively than it would on its’ own.

However, to try and get close to matching the same kind of constant systemic GH/IGF-1 elevation that MK-677 can provide coupled with CJC-1295 DAC, very frequent injections of the swapped in GHRP will have to be done, as the active life of GHRP’s are far shorter than MK-677, with Ipamorelin being the longest lasting one of all at 2 hours.

When it comes to viable GHRP’s to use while cutting, GHRP-6 is out the window, and I advise you forget about GHRP-2 as well unless you are one of the lucky ones who doesn’t get a hunger spike after pinning it (I’m not).

The only viable options that are left are Ipamorelin and Hexarelin, as these will not spike hunger.

I will eventually do a full peptide guide write up where I delve into how I would most effectively incorporate these different GHRP’s and GHRH’s in a cutting/bulking regimen, dosages, and what you need to know when it comes to saturation dosages and pituitary desensitization, which are all critical to take into account when you are designing your ideal peptide protocol.

Where To Buy CJC-1295 DAC And MK-677

Most peptide and SARMs sources do not third party test their products, nor do they have any quality control in place.

Before you buy anything from a company online, I advise that you evaluate their track record, their third party test results, and how they are marketing their products in general.

These are the only companies I currently use for my own personal research:

Science.bio – 10% off coupon code “DC10”

Chemyo – 10% off coupon code “DC10”

Amino Asylum – 20% off coupon code “DC20”

Swiss Chems – 25% off coupon code “DC25”

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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41 thoughts on “How To Replicate A HIGH Dose Of Pharma Grade GH With MK-677 And Peptides”

  1. Thanks for the great video. Tips for avoiding MK bloat? Does introducing the CJC-DAC have any effect on water retention?

    1. Ya it will probably make you bloat more. Higher the GH output, the more water retention potential until your body acclimates to it and it tapers off. Increase water intake, limit carb intake, cardio, regulate sodium, lots of things you can do that are pretty standard.

    1. To get the same IGF-1 score with Pharma Grade GH that’s $500+ per week, not to mention you will probably end up with fake GH with how difficult it is to source. Whereas with peptides and MK-677 the likelihood of fake product is FAR less.

    1. Don’t think it necessarily has a degradation effect on the pituitary or anything like that, but it results in a GH bleed as opposed to pulses, which some hypothesize can lead to IGF-1 related side effects at an expedited rate. I would think that this would be obvious that the longer your IGF-1 is in the supraphysiological range that the more risk you are at for IGF-1 related side effects though. I’d cycle it. I think it can be taken long-term in a cyclical fashion, but I wouldn’t use it for years on end without breaks personally. With that being said, I would do the same thing with synthetic exogenous GH shots too unless my dose was just keeping me on the high end of normal.

  2. If I was to run a test, tren and anadrol cycle for 8 weeks would the gh cycle you’ve laid out be efftive for only 8 weeks and should 5-10 units of insulin be used pre or post or not nesssary?

    1. You’re not going to create much hyperplasia in 8 weeks. GH is more of a long-term commitment for it to be worth it.

      Insulin use is dependent on your blood sugar levels. Using an arbitrary amount of 5-10 units makes zero sense.

      1. So what would be the minimum to get hyperplasia benefits from this protocol be in weeks? Also would the best way to gauge is to get blood work on glucose levels mid cycle to see if I’m going insulin resistant to then supplement with insulin pre and post?

        1. I can’t predict when your cells will splice themselves. You could do that but I think that using insulin with your carb meals as opposed to just pre and post would serve you better if you were around the clock dealing with elevated blood sugar, and obviously the amount would be dependent on your individual tolerance.

          1. Splicing cells for hyperplasia is almost like a long-term investment. The cells that are created for you to induce hypertrophy in may not achieve maturity (become big enough to make a noticeable difference) for years. This is why it is typically advised to run synthetic HGH for no shorter than 6 month spans of time. I cannot definitively say how long it took for me to see hyperplasia results as I have been using these compounds on and off for years now.

        2. what do you think about the combination of cjc dac + MK enhanced with mod grf and IP 2x per day when building muscle mass? As an extra boost. And what do you think about the reduction of frags only (combo of 2 types of frag), without cjc dac? Doesn’t it make sense to come down from CJC on reduction?

  3. I just started a semorelin/GHRH 2 blend from the doc. Question is which would make better for 24 hr elevation MK 677 or CJC w DAC? I know the semorelin has a short half life.

    1. MK-677 is pulsatile round the clock secretagogue, whereas CJC w DAC is a bleed. They both provide good 24 hour elevation. MK-677 on its’ own is stronger though if you were forced to only pick one.

  4. if i run the advanced protocol for 6 months would that give me acromegaly?
    what if i run it for an additional 6 months?

    if i use run testosterone and an AI during the cycle, would that prevent feminine development (hip widening) and promote masculine development (clavicle widening, torso growth)?

    1. I don’t predict the future.

      I highly doubt it though.

      You’re not going to get hip widening from Estrogen aromatization on a Test cycle. Keep your Estrogen in range with an AI obviously, but even if you didn’t it’s not like your taking pure Estrogen pills here. Yes taking Testosterone promotes masculine development.

  5. So I’m really new to peptides and I’m super confused because everyone uses 1ml insulin syringes. You first have to reconstitute the peptide using 2.5 mls of bact water which is like 2 and a half insulin syringes full. And then to dose 5mg on a syringe correctly I’m not sure how much that would be. I’m literally the absolute worst at math, and that’s why I’m having trouble

    1. You don’t have to reconstitute with 2.5 ml, you can reconstitute with however much you want, it will just alter your math for measuring at the end of the day.

      1. How would you personally reconstitute normally? Would you ever be willing to do a video on peptides like reconstitution and dosages? I’m a very visual learner so seeing the needles with the liquids in them as an example would really help me out so I know how much to put in, thank you.

        1. YouTube would remove it unfortunately so probably not. There are many guides out there though, just Google how to reconstitute peptides and you should be able to find something fairly easily.

          1. Thank you, I had multiple people message me nearly pages worth of info and I read it all, while I asked for more advice from others I got completely different answers furthering my confusion. Since math is abysmally difficult for me I have hard time learning without visuals. I watched a video that was informative but never showed the amount of liquid the syringe. Sarms are easy for me because I just need to add pills together, the math is essentially done for me while with peptides I need to do the math. If you ever get the chance I know you’re a busy guy, but if you could try to email me some photos explaining how to properly use the needles for reconstitution and dosing I’d be forever grateful, thank you.

      2. What dose of mk 677 do you think would match the Hollywood actors’ anti aging doses of HGH? (I believe it’s about 2 ius of HGH per day. What dose of MK would match that?) I think I’ll leave the muscle building to anabolics. I am far more interested in the anti aging and youthing effects of growth hormone

  6. If you’re following the advanced protocol that’s 3 bottled a week right? Since there’s only 5mg of peptides per bottle.

    1. All we know is that levels stay elevated and slowly diminish as the hormone works its way out of the system. The main takeaway is there is a big systemic elevation, and it isn’t the result of pulsations (traditional), it’s simply consistently elevated and slowly diminishes (if consistent dosing is not maintained). The word “bleed” is often taken out of context in regards to CJC-1295 DAC. I don’t think you can prove one way or the other, but the point of it is more so to exemplify that you can pin this once and get systemic elevation for a long span of time as opposed to jabbing Mod GRF 1-29 with your choice of GHRP a million times per week to replicate the same benefits.

  7. Hi, Derek!

    Is it okey to this CJC-1295 DAC + MK-677 + Huperzine A for 12 weeks or is it too long?

    Thank you

    1. Hey Derek,

      I see conflicting info and would love your take. Do you take the CJC-1295 before bed *on an empty stomach*? Most sources say on an empty stomach, which to me doesn’t make sense, given the incredibly long half life.

  8. I would really like to see that guide you mentioned you might do sometime about peptides. Especially the ghrp for cutting and that protocal.

  9. based on what you find online Somatropin is bad as it might shut down ur normal production however peptides are the best thing NO SIDE EFFECTS 😀 will help shred and grow……
    i trust ur recommendations

    HAVE you done that?

    “I will eventually do a full peptide guide write up where I delve into how I would most effectively incorporate these different GHRP’s and GHRH’s in a cutting/bulking regimen, dosages, and what you need to know when it comes to saturation dosages and pituitary desensitization, which are all critical to take into account when you are designing your ideal peptide protocol.”

  10. Derek, in a video from 2020 “My Current HRT Protocol – New Shipment Unboxing” you talk about wanting to reduce IGF-1 during a cut (using Metformin).

    I am about to cut and wan to use this CJC DAC protocol. While it increases GH, which should help with the fat loss, it also ratchets up IGF-1. For this reason, would you not recommend using this protocol?


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