So you probably already know how MK-677 on its’ own can replicate a modest dose of high quality GH (Growth Hormone).
Mk-677 has a level of diminishing returns (once you pass 25mg per day), and it cannot replicate a very high dose of pharma grade GH no matter how much MK-677 you take.
However, there is something you can add in that will potentiate each MK-677 GH pulse to an extreme degree.
So much so that it will drive IGF-1 levels up to match that of a HIGH dose of pharma grade GH.
(If you haven’t heard of MK-677 then I suggest you go checkout my articles and videos I made about it in 2016/2017 first).
That addition is CJC-1295 DAC.
Also commonly referred to as CJC-1295 With DAC.
CJC-1295 DAC is what I combined with MK-677 when I was younger (and cared a lot more about getting as big as possible) to replicate the IGF-1 levels that pharma GH yield, without having to go out and try and source pharma GH or pay the absurd price tag for it.
If you don’t already know of all of the benefits of elevated HGH and IGF-1 levels, I wrote out a comprehensive list of them in my MK-677 overview article that you can check out.
CJC-1295 DAC is a potent Growth Hormone Releasing Hormone (GHRH).
Do not get CJC-1295 DAC confused with Modified GRF (1-29) often abbreviated as Mod GRF (1-29), and also often referred to as CJC-1295 No DAC which needs to be shot multiple times per day with a GHRP to achieve a substantial benefit.
It’s important that you know the difference as Mod GRF 1-29 is absolutely useless to use with MK-677 as you can’t manually match the pulses of MK-677 to the active life of the Mod GRF 1-29.
CJC-1295 DAC is a modified version of the first 29 amino acids of Growth Hormone Releasing Hormone, together with addition of a “Drug Affinity Complex” (referred to as DAC).
The combination of modifications and the addition of “DAC” provide a half-life of about 1 week, and steady blood levels after it is injected.
While the mechanism of action behind MK-677’s ability to increase GH and IGF-1 levels is the stimulation of the Pituitary Gland to pulse out 12 very strong pulses of GH over the course of every 24 hours, the mechanism of action behind the GH/IGF-1 boosting effects of CJC-1295 DAC are quite different.
CJC-1295 DAC results in a bleed of GH to be released over a longer span of time.
It doesn’t stimulate short, strong burst-like pulses like Mod GRF 1-29 couples with other pulsatile GHRP’s do, rather, it simply amplifies the potential of the current pulses occurring in your body via this slow GH bleed effect, making them more effective and raising HGH/IGF-1 levels to a much greater level.
Because CJC-1295 DAC has a long half-life, it produces a GH bleed effect, where the strength of every single GH pulse that occurs during that span of time that the CJC-1295 DAC is in your system is amplified several fold.
Now, on its own, CJC-1295 DAC isn’t overly helpful when it comes to muscle building potential.
But, combining MK-677 (which is a potent GH Secretagogue that results in several new and strong GH pulses in the body) with CJC-1295 DAC (which provides an amplifying GH bleed effect) results in a 1 + 1 = 3 type of results.
By that I mean that by combining the two, they work synergistically to provide benefits that would otherwise be impossible to achieve with each compound used on their own separately.
CJC-1295 DAC amplifies the strength of the MK-677 pulses essentially, resulting in sky-high HGH/IGF-1 levels.
Mod GRF 1-29 Vs CJC-1295 DAC For Building Muscle
Now, there are arguments in the bodybuilding world about why a GH bleed is bad, as it doesn’t match the natural pulsatile fashion of real growth hormone pulses from the pituitary gland, and strong GH pulses are what are necessary to constantly have throughout the day to build copious amounts of new muscle yada yada yada.
At the end of the day, the fact remains that GH DOES NOT build muscle well, rather the pathway to new growth via GH use is completed with the constant systemic elevation of IGF-1 levels in the body that multiple daily shots of synthetic GH accomplish once they are converted in the liver.
So, to get the muscle building effects that we want from GH, we need our IGF-1 levels cranked through the roof.
Well, it just so happens that although CJC-1295 DAC doesn’t cause multiple short GH pulses like the human body is programmed to do, rather, its’ GH bleed results in a modest elevated GH serum and IGF-1 level around the clock.
And when combined with MK-677, which acts 24 hours around the clock self-pulsing GHRP in itself (and a GHRH in some capacity as well), IGF-1 levels can get extremely high and stay extremely high for long durations of time.
This = huge muscle growth potential
High levels of GH = minimal muscle growth
High levels of IGF-1 = greatly increased muscle growth potential
If you want to make the most of whatever GH related enhancements you are going after, keeping IGF-1 levels elevated for as long as you can each day is the key to maximizing your progress.
Pulsing Peptide Protocol Vs Peptide Induced GH Bleed Protocol
With a standard pulsing protocol with Mod GRF 1-29 with a GHRP even shot 3x per day (the gold standard), you are achieving GH elevation for only 4.5 hours per day, and only 9 hours per day if you are hardcore and do 6x Mod GRF 1-29 + GHRP peptide shots per day around the clock.
With CJC-1295 DAC, you are getting a bleed resulting in elevated GH and IGF-1 levels 24 hours per day, along with MK-677’s 24 hour constant pulses, you are sustaining high dose pharma grade GH IGF-1 score levels all day long.
Here Is A Beginner’s MK-677 And CJC-1295 DAC Research Protocol:
2500mcg CJC-1295 DAC subQ inject before bed – Monday & Thursday (5000mcg – 5mg total per week)
25mg MK-677 before bed every day
200mcg HUPERZINE A taken 3x per day (600mcg total)
With this protocol, you can reach an IGF-1 level of about 500ng/mL. This is formidable to a very fair dose of pharma grade GH.
This is obviously dependent on several factors, as we know that IGF-1 depending on diet and amount of exercise performed in the last 24 hours will vary 10-15%.
It is also dependent on that individual’s genetic predisposed response to synthetic GH, GH peptides, and GH secretagogues of course.
This lGF-1 level should be more than enough for anybody who isn’t trying to compete at a professional bodybuilding level.
For the record, this is the protocol I used myself when I used to use CJC-1295 DAC with my MK-677.
Here Is A VERY Advanced MK-677 And CJC-1295 DAC Research Protocol:
With this protocol, IGF-1 levels will exceed, or at least match a HIGH dose of pharma grade GH:
3333.33-5000mcg CJC-1295 DAC subQ inject before bed – Monday, Wednesday, Saturday (10,000-15,000mcg – 10-15mg total per week)
25mg MK-677 before bed every day
200mcg HUPERZINE A taken 3x per day (600mcg total)
With this protocol, you can reach an IGF-1 level close to (or exceed) 700ng/mL.
Which is absurdly high, and shouldn’t even be necessary unless your goal in life is to compete at a high level.
The dosage for this protocol is a range because some individuals can achieve a much higher IGF-1 level than others with a lower dose, whereas some individuals need a higher dose to reach that same IGF-1 level.
The side effects from this protocol will parallel the same side effects you get from synthetic GH.
In addition, MK-677 specific side effects include increased hunger from increased Ghrelin, and CJC-1295 DAC specific side effects include facial flushing (doesn’t always occur) post injection.
If You Are Cutting
If you are cutting and wanted to utilize this kind of protocol to replicate a high dose of pharma grade GH but can’t handle the hunger induced by the Ghrelin spikes from the MK-677, then simply swapping it out for another GHRP that doesn’t spike Ghrelin levels would suffice.
CJC-1295 DAC works around the clock, so whatever GHRP you introduce will work several fold more effectively than it would on its’ own.
However, to try and get close to matching the same kind of constant systemic GH/IGF-1 elevation that MK-677 can provide coupled with CJC-1295 DAC, very frequent injections of the swapped in GHRP will have to be done, as the active life of GHRP’s are far shorter than MK-677, with Ipamorelin being the longest lasting one of all at 2 hours.
When it comes to viable GHRP’s to use while cutting, GHRP-6 is out the window, and I advise you forget about GHRP-2 as well unless you are one of the lucky ones who doesn’t get a hunger spike after pinning it (I’m not).
The only viable options that are left are Ipamorelin and Hexarelin, as these will not spike hunger.
I will eventually do a full peptide guide write up where I delve into how I would most effectively incorporate these different GHRP’s and GHRH’s in a cutting/bulking regimen, dosages, and what you need to know when it comes to saturation dosages and pituitary desensitization, which are all critical to take into account when you are designing your ideal peptide protocol.