I found the following study really interesting because to date, no other study has reported findings using a higher steroid dosage.
The study is called “Effect of Methenolone Enanthate in Advanced Cancer of the Breast.” [R]
The study compares 1200 mg of Primobolan per week against 300 mg of Testosterone Propionate per week.
1200 mg of Primobolan per week is the highest steroid dosage that was found to be generally well tolerated in a clinical setting.
What's even more interesting about it is the study was conducted on women.
If an anabolic androgenic steroid is generally well tolerated in women at such a high dosage, it's probably fair to say that it has a favorable safety profile.
Abstract of “Effect of Methenolone Enanthate in Advanced Cancer of the Breast”
“Methenolone Enanthate, a synthetic, long-acting anabolic steroid, was evaluated by a randomized study in the treatment of advanced carcinoma of the breast in postmenopausal women following the protocol established by the Cooperative Breast Cancer Group.
Of 27 patients receiving, Primobolan Enanthate, 48% had objective improvement.
There were no improvements in 13 patients receiving Testosterone Propionate.
The median duration of therapy and the median period of survival from the onset of hormone therapy to death, or present living time was greater for the responders to Methenolone Enanthate, also known as Primobolan than the nonresponders.
The unusual high incidence of regression from Methenolone Enanthate therapy may be due to the massive dose employed, a defect in the method of study being employed in clinical trials, a difference that could occur by chance alone, or a significance in the biological nature of the disease in the two groups.
Since the difference may indicate that Methenolone Enanthate is an effective hormone, further studies are warranted.”
This study evaluates the side effect profile of a supraphysiological dose of the main endogenous androgen in men and women in comparison to a massive dosage of Primobolan.
Keep in mind, Primobolan is a DHT derivative.
Granted the androgenicity of Primobolan is not typical of something derived from DHT, but it's still derived from DHT nonetheless.
The fact that almost half of the women administered 1200 mg of Primobolan per week in this study generally tolerated it, while none of the women in the Testosterone administered group could tolerate even 300 mg of Testosterone per week just goes to show how efficacious Primo actually is.
Granted, the sample size in this study is very small, but even with that being said, if an anabolic androgenic steroid is selective enough for anabolic activity relative to androgenic activity where quadruple the dosage of Testosterone per week can be used without the majority of women experiencing horrendous side effects, that is worth exploring further.
Is Primobolan A Weak Anabolic?
A lot of guys write off Primo as a weak anabolic.
This is something I used to do too.
To be honest, I never even used it because I just always wrote it off.
This was back when I used to blast and use supraphysiological dosages of steroids.
I perceived it as a subpar hormone and had the same preconceived notion your common gym bro would have.
A quick disclaimer before we continue, no dosage of anabolic steroid is “safe”.
In terms of human studies and safety data though, Primobolan is one of the most science-backed, clinically safe, and most well-tolerated anabolic steroids that exists.
Objectively looking at it, even in extreme applications, we have very positive feedback on it in a clinical setting, even in women who have a much lower threshold before they start experiencing limiting side effects.
The 1200 mg of Primobolan per week wasn't just for a short duration of time either.
Primo was administered for 16 weeks at this massive dosage.
Below is a graph of the side effect profile of the study:
Out of the participants, 48% experienced an increase in their well-being.
Only 52% reported Hirustism, which is a pretty typical side effect in women who are producing more androgens than normal.
The fact that 1200 mg of Primo per week still only resulted in a 52% increase in Hirustism when Testosterone and DHT levels lower than a hypogonadal old man in women with PCOS will cause it really sheds light on Primobolan's lack of androgenicity relative to other steroids.
Most bodybuilders wouldn't even use 1200 mg of Primobolan.
Primobolan In A Performance-Enhancing Context
I'm not trying to advocate Primobolan by any means for performance-enhancing purposes.
I'm just saying, if you're going to go down that route, there are steroids that are efficacious and are well tolerated by the body that would be wise to choose before you use some hormone with a complete lack of human data, or a sketchy side effect profile in the data we do have.
Now, that's not to say I'm not for experimentation and explorative research.
Just from a smart and logical health standpoint though, your risk profile will be lower if you choose hormones that are tried and true and have a lot of clinical testing behind them.
Opt for the efficacious compounds that have more favorable safety profiles and predictable outcomes.
Potential Clinical Uses For Primobolan
Interestingly enough, it looks like Primobolan is actually being looked at in a clinical setting for other potential uses.
For example, Primobolan metabolites are actually being looked at right now for their applications as an anti-inflammatory because they have a high level of selectivity and lower toxicity than Glucocorticoids.
Primobolan is a really interesting compound.
Unfortunately, Primobolan is highly faked in the market.
With that being said, legitimate accurately dosed Primobolan I feel is a very underrated and efficacious hormone for the applications in which it is intended to be used.