Table of Contents
What Is RU58841?
RU58841 is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness).
While it certainly isn't a hair loss cure, RU58841 is the most promising anti-androgen available for preventing hair loss.
I have over 3 years of experience with this stuff.
What Causes Hair Loss in The First Place and How Will RU58841 Help Prevent It?
DHT is the main cause of hair loss in men.
DHT (a necessary and otherwise useful hormone) binds to androgen receptors and miniaturizes hair follicles in those prone to MPB (male pattern baldness).
This is why it is far more common for men to go bald than women.
Testosterone converts to DHT in the body, and since men have much higher levels of testosterone in their bodies than women, men who are prone to MPB consequently (and inevitably) are more likely to suffer from extreme hair loss.
Almost every single case of hair loss is caused by DHT; there is less than a 1/100 chance your hair loss is caused by another factor (unless you are expediting it with anabolic steroids).
So, the only way to combat hair loss, is to directly combat DHT (or androgens if you use gear).
RU58841 helps prevent this significantly when topically applied to the scalp.
It works by competing with DHT and Testosterone for androgen receptor binding.
When protected by RU58841, scalp hairs can grow to maturity and not be miniaturized by DHT.
A study in the Journal of Steroid Bio-Chemistry and Molecular Biology concluded the exceptionally high topical activity of RU-58841, combined with unprecedented tissue selectivity with respect to systemic effects, suggest that this compound is a candidate of choice for the local treatment of androgenetic alopecia.
How I Use It, Store It, And Know If It’s Working
A standard dose of 50 mg once per day applied all over the scalp in areas prone to male pattern baldness should suffice, but some individuals may require more (this is dependent on a variety of individual-specific factors).
After applying 50 mg over the necessary areas, I rub it in with my fingertips to make sure the liquid is covering the areas entirely, and then let it dry (it takes less than a minute to dry).
Afterwards, you can apply your Minoxidil if you use that too.
I apply RU58841 after I've washed my hair, and my hair is completely dry.
Ideally, I try to apply it within 30 minutes after showering because the scalp produces sebum which can act as a barrier to RU58841 penetrating the skin and blocking DHT topically.
I don't usually follow this religiously though as I find it much more convenient to apply it before bed each night.
I haven't noticed much (if any) of a difference, but the method mentioned above is the optimal way to apply it.
RU58841 is a bit watery, so it is best to apply within and behind the hairline.
Regarding storage, mixed RU58841 solutions should be stored in a fridge, and RU58841 raw powder should be stored in a freezer in order to last for as long as possible.
Exposing RU58841 to light or higher temperatures will cause degradation of the compound.
Personally, I store my RU mixed solutions in my fridge in 50ml bottles, and my RU raw powder in my freezer, in a tightly sealed Ziploc bag placed inside a small container.
While many people have no idea how much hair they are losing until it becomes obvious that their hair is receding or looks thinner, I suggest that you start keeping an eye on your hair catcher in the shower drain (if you don’t have one it might be wise to get one to gauge your hair loss intensity).
When you shower, if you are very prone to hair loss it may be typical for you to lose 50-100+ hairs in the shower each time you wash your hair.
A great way to assess if RU58841 is working for you is by keeping an eye on the hair catcher and doing a rough count of the hairs lost at the end of each shower.
Obviously I don’t mean literally pick out each individual hair and count them, but it will be pretty obvious if after you start using a hair loss prevention compound there are less hairs in the hair catcher than there usually are.
Within a couple weeks of using RU58841, I went from losing 50+ hairs every shower, to losing 1-5 hairs max.
It was pretty amazing to say the least, and within a month or so I started noticing density coming back to my previously diffuse thinning scalp.
How Do Topical Anti-Androgens Compare To Finasteride And Dutasteride?
Both Finasteride and Dutasteride work by inhibiting the production of DHT, indirectly preventing hair loss because there is simply no DHT left to negatively affect your scalp.
RU58841 on the other hand competes for androgen receptors, leaving DHT levels intact, and just partially prevents it (depending on the dose) from binding to receptors and causing the miniaturization that ensues in those prone to hair loss.
On paper, and in practical application in numerous individuals, topical anti-androgens that locally bind to androgen receptors and leave systemic androgen levels intact may be a superior alternative to Finasteride and Dutasteride.
Why Topical Anti-Androgens Are More Promising For Steroid Users In Particular
It is important to note that Finasteride (which is typically the first resort for guys looking for hair loss prevention) is very effective for treating hair loss related to steroid usage, BUT will only protect you from Testosterone converting to DHT.
Although it is a common belief that DHT derived steroids may have their androgenic effect inhibited as well, this belief is incorrect, as they do not convert into more androgenic compounds via 5-AR.
Finasteride is a type 2 5-AR inhibitor, not an anti-androgen.
Since 5-AR is what is necessary to convert Testosterone to DHT, Finasteride (a 5-AR inhibitor) will absolutely not be effective against DHT created by Dianabol, trenbolone, anadrol, winstrol, masteron, equipoise, etc.
Consequently, your options for steroids you can run will be severely limited as you will essentially only have hair loss protection against mild doses of testosterone.
Testosterone at high enough doses will still cause androgenic alopecia in individuals prone to hair loss, even if on Finasteride.
RU58841 competes with all steroids for androgen receptor binding, it has no bearing on the activity of 5-AR.
RU58841 Effect On Your Results/Gains Vs. Finasteride/Dutasteride
Based on the literature available, neither RU58841 or 5-AR inhibitors have shown any negative impact on muscle growth or strength metrics.
What Else Should I Be Using To Prevent Hair Loss
Even if you're using a topical anti-androgen, there are some other compounds that are worth considering stacking alongside it.
- Ketoconazole shampoo: A high quality Ketoconazole shampoo should be applied by rubbing it into your scalp, and leaving it for 5-10 minutes before washing it out, each time you wash your hair. Ketoconazole is a powerful antifungal, and also behaves as a mild anti-androgen. It works well and I use it alongside my RU58841. A high quality Ketoconazole shampoo differs from Nizoral in that it contains a variety of other useful ingredients that Nizoral does not contain, and as a result, it won't dry your hair out like Nizoral potentially could. However, Nizoral is quite a bit cheaper, so it's not a bad idea to alternate between a high quality Ketoconazole shampoo and Nizoral to save money. If Nizoral doesn't cause your hair to dry out, I would stick with that as it is cheaper and has the same amount of Ketoconazole in it anyways (the ingredient you want).
- Minoxidil: Minoxidil will actually revitalize hair follicles and regrow hair that has been lost. It is amazing stuff. There is a clear difference between brands though, so I would recommend getting a high quality Minoxidil that is formulated to leave your hair presentable and not oily/greasy like most generic brands (e.g. Kirkland).
- Finasteride: Finasteride is worth evaluating as well, as it can be used as an adjunct to a topical anti-androgen to strengthen your protocol, but the use of either should be carefully considered against a variety of individual specific criteria.
Where To Get RU58841
Pre-mixed RU58841 solutions (or the Raw RU58841 Powder if you want to make your own solutions) can be ordered here: Anageninc
The only other company I also trust with equal quality is the following: Chemyo
I haven't noticed a difference in quality between the two.
For the carrier (what the RU58841 raw powder is mixed in), I prefer PG (propylene glycol) + Ethanol.
I would find it rare for someone's scalp to be irritated by the PG/Ethanol to the point of needing to use KB as the carrier instead. Both carriers work fine, some people just seem to have skin irritation to particular carriers as opposed to others.
You won’t grow a thick mullet on a severely balding head overnight using any hair loss prevention compounds so keep your goals realistic and be patient.
The key is hair loss prevention; any re-growth is a fringe benefit.