Man applying topical Estrogen cream to his head for hair loss prevention

Topical Estrogen Cream For Hair Loss Prevention – My Experience And Review

I've been asked a few times about topical Estrogen cream for hair loss prevention.

BiEstro-Care cream and Estrogel in particular.

BiEstro-Care is a is a combination of 1 mg of natural Estriol USP and 0.25 mg of natural Estradiol USP per pump.

I've also tried their Estradiol-only topical, Estradiol Care.

Each full press of the pump provides approximately 0.1 mg of natural Estradiol USP in that topical preparation.

I've also tried pharma grade Estrogel, which is an FDA-approved, bioidentical 17β-estradiol transdermal gel at 0.06% w/w strength.

Estrogel Tube

The hypothesis in the community is that the topical Estrogen cream will bind to Estrogen receptors in the scalp and produce a more conducive environment for hair loss prevention without going systemic as it remains localized on the scalp.

Think of it like topical Minoxidil vs oral Minoxidil.

The topical version doesn't go systemic to the same degree, and still exerts significant pro-circulatory effects.

Localized Estrogen Receptor Activation

On paper, it is easy to extrapolate the potential benefit of being able to topically apply Estradiol or Estriol and get some sort of localized binding with a relative lack of systemic estrogenic activity.

However, it just doesn't seem to work like that in practical application.

I noticed absolutely no difference on my hair growth or hair loss prevention, whatsoever.

It's also not very predictable in terms of pharmacokinetics in the body going through the scalp.

Does Topical Estrogen Cream Promote Hair Growth

I can confirm that topical Estrogen cream on the scalp is very poorly absorbed and has minimal impact on hair growth, or the progression of androgenic alopecia.

I checked my blood work via a high sensitivity assay (LC/MS-MS) and I was actually shocked at how poor the systemic absorption was through the scalp.

If your goal is to try and maintain physiologic amount of systemic estrogen fulfilled via transdermal administration of topical Estrogen cream, you will likely be unsuccessful.

The absorption through the scalp is extremely poor.

I was drenching my head in this stuff to really test it out.

Even when I had several milligrams of Estradiol cream on my head per day, my E2 levels were low.

The hypothesized topical localized effect on Estrogen receptors also doesn't seem to play out as we thought it may.

I noticed no additional growth out of it, and feel that it is an overhyped growth agonist that may just do more harm than good.

The most notable biomarker that changes with topical Estrogen cream on the scalp is Estrone, which goes through the roof.

To date, I have never seen anyone actually get good results from topical E2 to begin with, and any cases of regrowth with its use were in cases where other therapies were used in conjunction with it.

Anybody who deploys this as a form of monotherapy to prevent hair loss will be disappointed with their lack of results in my opinion.

At the end of the day, preventing hair loss at the root of the issue just boils down to managing your overall systemic androgenicity relative to systemic estrogen levels.

My Verdict On Its Efficacy For Hair Loss Prevention

As a growth promoting agent (what it would mainly excel at), I feel that is probably not even worth exploring to be honest.

It certainly doesn't seem to exert any antiandrogen-like effects at the androgen receptor either that would justify its use in my opinion.

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17 thoughts on “Topical Estrogen Cream For Hair Loss Prevention – My Experience And Review”

  1. I’ve used ru58841 50mg at 1ml for 4 days now, day 3 had light chest sensations, thought it might be nocebo effect. Day 4 used full dose, next day left testicle started aching. day 5 testicle still aches, and lower abdomen is spazzing. Libido is through the roof which is weird af, sex drive is stupid high I am horny all day long wanna fuck everything I see. Testicle pain is enough to force me to discontinue use unfortunately. Weird experience, thought I would share for whoever is interested.

  2. Ive been using ru58841 50mg in KB/ 1,25 ml for 1,5 year now and it literally saved my degree, relationship etc.

    1. I sometimes feel the DHT „effecting“ the parts on my scalp where i didn’t apply it e.g. the sides and back scalp, thus been experiencing hairloss and itchiness there. Would you recommend going full scalp Ru?

    2. Where would the DHT „go“ if not docking on the hair follicles receptors? Do they stay in the system e.g. the neck area etc?

  3. What is a good range for free roaming testosterone that would support functions even if dht is suppressed? Going to get blood work done and want to know if there is a range that is safest so I can check when my blood work comes back if I decide to take finaateride if my body can support it with minimal side effects.

  4. Thanks derek, as always man best content for health, fitness and hairloss prevention!, by chance have you known anyone who switched from 5% ru58841 to 3% ru58841 after side effects and had good outcome?

  5. Hi, Derek, a big fan here!
    Sorry for my english, it isn’t my native languaje.
    Have you considered topical dudasteride ? (Not mesotherapy, only usual topical aplication with normal vehicles) I’ve been reading a lot about it and seems that it can reduce to a big extent scalp dht while getting systemic only a little (due to molecular weight, only once a week application, etc )

  6. Derek,

    Once u start RU, do the hairs become dependant on the chemical like the way minoxidil works? If I stop using RU, will I have hair fall? I. Also using minoxidil,finasteride, and derma rolling. Thanks

  7. Good article Derek. I’m sure you already know that AI’s like aromasin, and especially letro, will wreck havok on one’s hair. I believe people that are taking an AI for gyno combative reasons would benefit the most from topical estrogen because it would mitigate the negative effects of the AI on their hair. The topical estrogen not going systemic is a positive, not a negative, in my opinion.

  8. It seems the topical absorption of estradiol through intact scalp is quite poor, but has anyone tried a micro needling roller to create very small breaks in the epidermis to enhance absorption?

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