An image showing Derek holding a bottle of CB-03-01 while giving a CB-03-01 review

CB-03-01 Review (Breezula) | Is It The Cure For Hair Loss?

I finally got around to trying CB-03-01.

I had heard varying opinions on its therapeutic promise in the community, but at the end of the day I had to do a CB-03-01 review myself to see if this compound is superior to other alternatives we already have at our disposal.

Breezula (developmental code name CB-03-01) is a synthetic steroidal antiandrogen being developed as a potential treatment for androgenic alopecia (male-pattern baldness).

CB-03-01 is probably going to be the first topical antiandrogen that actually gets approved for human use as a hair loss prevention treatment.

The first thing that should be stressed when it comes to something like this is that regrowth will not be common with its use.

Prevention is the goal with something like this.

The clinical data on CB-03-01 isn't overly impressive in terms of hair loss prevention and reversal.

The main issue with treatment options like this are expectations.

You should lower your expectations when it comes to topical antiandrogens.

Preventing further loss is the goal, and any regrowth is a fringe benefit.

Having something with a high level of tolerability, low side effect profile, and can also effectively compete at the androgen receptor locally with ALL endogenous androgens, can be a critical component of a comprehensive hair loss prevention protocol.

CB-03-01 doesn't inhibit DHT systemically like Finasteride or Dutasteride, it leaves endogenous androgen levels in tact, but competes locally at the androgen receptor.

RU58841 Vs. CB-03-01 Results – In My Experience

Having years of experience under my belt with RU58841 and other topical compounds, I felt like I had a good reference point to judge the overall efficacy of CB-03-01.

For me personally, CB-03-01 didn't cause any side effects, and neither has RU58841.

How effective was it as a topical antiandrogen?

Mild in my opinion, but still promising.

RU58841 seems stronger to me, however, that doesn't mean that something with a lower potency milligram for milligram can't just be dosed higher to yield a similar outcome.

The issue with that is that CB-03-01 is extremely cost prohibitive right now.

A minority of individuals have found CB-03-01 to be more tolerable than RU58841 with a formidable antiandrogen effect.

However, the majority of individuals, myself included, have not found it to be on par with RU58841, and it is far more expensive.

CB-03-01 Vs. Other Topical AntiAndrogens

If a very high dose of CB-03-01 was the same price as a moderate dose of RU58841, then I believe that would then potentially justify it as the superior alternative, but as of now it seems that there are more cost effective alternatives to CB-03-01 that are also just as effective, if not more effective.

And that's just comparing CB-03-01 to what is viewed in our community as the most traditional antiandrogen.

I believe there are other topical androgen receptor agonists and antagonists that could also have more therapeutic promise than both.

For example, the molecular weight of certain Selective Androgen Receptor Modulators are low enough to work topically (in theory).

I've elaborated on the therapeutic promise of SARMs in a hair loss prevention context before, and I have already seen this in real life application.

The binding affinity of most SARMs are also significantly better than CB-03-01.

With all that being said CB-03-01 is the only topical antiandrogen that is currently being developed for hair loss prevention and has a growing amount of safety data for us to refer to.

For most people, the obvious choice of which topical treatment to use would be the one with the most safety data on it.

Based on what I've seen, CB-03-01 may be moderately effective for some individuals at holding their ground.

And realistically, you can't really expect a whole lot more than that from a topical antiandrogen that doesn't affect the endogenous hormone profile at all.

This is the kind of thing you would start taking before you notice hair loss to maintain, not something you would implement once you've receded several Norwoods and have severe diffuse thinning.

Deploying CB-03-01 before hair loss gets too severe may be sufficient in maintaining perfect hair with minimal side effects for years, if not decades.

A proactive approach needs to be taken to hair loss prevention, not a reactive approach once you've already experienced significant amounts of miniaturization.

Using this as a reactive approach to make up lost ground will likely yield less than satisfactory results because it is a prevention/maintenance drug.

Facilitating significant regrowth would require more intensive protocols with less favorable side effect profiles.

CB-03-01 Limitations


Price is one CB's of the biggest limitations right now.

There are very few companies selling it, and the ones that are have it priced several times higher than alternatives that are just as effective.

In addition, CB-03-01 requires an even higher daily dosage than the cost-effective alternatives, making it even more cost prohibitive.

The results of the human trials have shown that a minimum of a 7.5% strength solution would be needed, and it may even need to be applied twice per day to achieve sufficient maintenance.

That's 150 – 450 mg of CB-03-01 per day just to potentially achieve maintenance (depending on how much solution you need to use to get full scalp coverage with each application).

You could easily end up spending over $100 – $300 per week just to use the minimum effective dosage of CB-03-01, and still be underwhelmed with your results.

With that being said, once Breezula is available as an FDA approved treatment, perhaps the price will become less of a concern, but as of now it is just too cost prohibitive for most of us at the dosage needed to yield sufficient hair loss prevention.


Preventing loss is what should be expected of an effective antiandrogen.

It seems like in less aggressive cases CB-03-01 is mildly effective in doing that.

For many individuals though, it is not turnkey monotherapy option.

Does that mean its useless?

No, not at all.

It is definitely a better line of defense than nothing, that's for sure.

For individuals with more aggressive loss who have implemented CB-03-01 with subpar results, they would likely need to add other compounds into their protocol.

Complementary compounds to CB-03-01 for a more comprehensive protocol may include things like 5-alpha reductase inhibitors, PGD2 inhibitors, PGE2 agonists, potassium channel openers, Non-Steroidal SARMs, Steroidal SARMs, antiandrogens, other bioidentical sex hormones, etc.

The most obvious first choices for most individuals being Finasteride, Minoxidil and a Ketoconazole shampoo.

CB-03-01 (or another formidable topical antiandrogen) used in conjunction with a 5-alpha reductase inhibitor, Minoxidil and a Ketoconazole shampoo will be effective in staving off hair loss for decades for many individuals.

Is it the most effective option?

No, however, it is tried and true and has a fairly predictable side effect profile with lots of human clinical and anecdotal data to refer to.

Keep in mind, treatment options can have a compounding effect in protection, and there can be many pathways to address.

For example, if you are just using Finasteride to inhibit 5-alpha reductase, sure you will knock out a fair chunk of your systemic and scalp DHT, but what are you doing to protect you from the rest of the unaddressed DHT?

And what are you doing to address the massive spike in scalp Testosterone that comes along with inhibiting the 5-alpha reduction of Testosterone into DHT?

Despite many treatment options being marketed as “treatments”, the reality is that most of them just address one pathway in the body, and can even precipitate other issues that then need to be addressed with adjunct treatments.

Remember, DHT isn't the only androgen in the body that causes hair loss.

This is why topical antiandrogens have such therapeutic promise.

Clinical Trial Results

Cassiopea recently published the results of their 12 month clinical trial [R]:

Six Month Interim Analysis Efficacy Results

Primary Endpoints at 6 months (interim analysis on 375 subjects) Clascoterone
2.5% BID
5% BID
7.5% BID
7.5% QD
Mean changes from baseline TAHC 13.0134 12.2109 20.7879 11.5182 -0.1114
P value (vs. baseline) < 0.0001 < 0.0001 < 0.0001 < 0.0001 0.9660
P value (vs. vehicle) 0.0003 0.0010 < 0.0001 0.0017
Favorable HGA (+1, +2, +3) 56% 58% 62% 61% 49%

As you can see, favorable hair growth assessment (HGA) improved in all CB-03-01 treated groups compared to the vehicle treated group.

With a lack of side effects and a high level of tolerability, CB-03-01 looked very promising at the six month mark.

However, the twelve month mark showed less encouraging results.

Twelve Month Analysis Efficacy Results

TAHC Per Protocol (344 subjects) At 12 months Clascoterone
2.5% BID
5% BID
7.5% BID
7.5% QD
Mean changes from vehicle TAHC (n.) 10.2 13.8 14.3 12.7
P value (vs. vehicle) 0.0087 0.0006 0.0003 0.0016
HGA Per Protocol (344 subjects) Clascoterone
2.5% BID
5% BID
7.5% BID
7.5% QD
At 12 months
Favorable HGA (+1, +2, +3) 60.8% 60.0% 61.8% 56.1% 50.0%
Per Protocol (344 subjects)

At 12 months
2.5% BID
5% BID
7.5% BID
7.5% QD
Mean changes from vehicle TAHW (µm) 521.1 615.0 762.5 658.8
P value (vs. vehicle) 0.0105 0.0034 0.0003 0.0018

As you can see, the vehicle increased from 49% > 50% favorable HGA at 12 months, whereas 12 months using the highest dosage of CB-03-01 once per day caused a 4.9% drop in favorable HGA.

That means that the group who was not treated with anything were perceived to have better results than the group that was using a high dose of CB-03-01 once per day by the twelve month mark.

Now, keep in mind that favorable HGA only represents the opinion of the patient on hair growth, expressed with a questionnaire.

It is subjective, but at the end of the day, it is not rocket science to look at before and after pictures of your hair and see if you are happy with your progress or not.

Also, this is only one dosage arm, but still, it's not overly promising, unfortunately.

Twice per day dosing of the highest CB-03-01 concentration dropped 0.2% by the twelve month mark, which could be argued to be representative of maintenance, but with how expensive this stuff is (as of now) using a 7.5% strength solution twice per day is not really realistic, let alone once per day.

With all that being said, even if maintenance is achieved with a complete absence of side effects, that would be considered a win for a topical antiandrogen candidate.

Binding Affinity Of CB-03-01 Vs. RU58841

CB-03-01 binds to the androgen receptor with approximately 100-fold lower affinity than DHT [R].

A common feature of pure antiandrogens, such as Hydroxyflutamide and Casodex, is their relatively weak binding affinity for the androgen receptor, 50–100 times less than that of Testosterone.

However, RU58841 binds to the androgen receptor with an equivalent affinity to Testosterone (ka = 1.1 nM) [R].

DHT has a binding affinity of 0.25-0.5 nM for the human AR, which is about 2-3 times higher than that of Testosterone [R].

By extension, we can estimate that CB-03-01 binds to the androgen receptor with approximately 40-fold lower affinity than Testosterone.

Consequently, we can assume that RU58841 has a binding affinity 40 times higher than CB-03-01.

Topical RU58841 also showed no detectable abnormalities in body weight, hematology, and blood chemistry tests, serum levels of testosterone, dihydrotestosterone, and luteinizing hormone during examination [R].

My CB-03-01 Review

At the end of the day, I do believe that CB-03-01 is promising, however, I do not believe that it is going to be a turnkey monotherapy solution that is effective in staving off hair loss in anyone with even moderately aggressive androgenic alopecia.

I also believe that there are more cost-effective alternatives that already exist that are also more effective at preventing hair loss.

With that being said, we still have to see if further research in the future reveals more promising data and if it becomes less cost prohibitive.

As of now though, I do not think that it is better than alternatives that are already available to us.

Where To Buy CB-03-01

Most CB-03-01 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I strongly advise that before you buy CB-03-01 from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These are the only companies I currently use for my own personal research:

(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)

Anageninc – 10% off coupon code “DC10”

Science.bio – 10% off coupon code “DC10”

Chemyo – 10% off coupon code “DC10”

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30 thoughts on “CB-03-01 Review (Breezula) | Is It The Cure For Hair Loss?”

  1. Derek, any advice on ru58841 usage, I’ve been using it for less than 2 weeks and an insane change In my diffuse thinning,and more density in less than 2 weeks, only thing is this chest feeling that comes and goes, wanna say its placebo based because of all the forums I’ve read but I’ve been using less that 50mg, and I dont wanna stop because of how good its working but wanna see if you have any advice ? Would it just be because some scalps are more permeable that others?

    1. Maybe. I wouldn’t keep using it if you’re getting chest pains on it. Lower your dose would be my first piece of advice. You might be a good candidate to try CB-03-01 if you get good results with RU but you experience side effects.

      1. I havent really made any adjustments, I’m going to be getting cb0301 and mixing it with the k and b solution, just making sure I use the right amount of cb so it works and I dont waste my money by not using the proper dose.

        1. K&B solution has too much water in it. It will breakdown the CB to its metabolite thus rendering it ineffective. Just use Ethanol/PG.

  2. If I did go with cb 03 01 can I mix 2.5 grams or 1 gram with the k and b solution I still have?? Not sure how to mix that antiandrogen and thanks man!! If I wasnt for videos my thinning would just keep getting worse and I’m only 22!!

    1. Yes it should mix fine in it. Some guys think it needs a special vehicle, but then others have success literally just mixing it with Everclear. K&B should be sufficient.

      1. I’m going to try 25mg of ru and see how that goes and if I still feel some chest stuff I’ll just get off of it,sucks cause it’s been working really good and cb is insanely more expensive than ru58841.

  3. What is your guesses to what could be causing the drop from 6-12 months? I find it also weird that the vehicle group gained more hair without any CB for a few months. Maybe whatever vehicle they used in their last trial is responsible for the loss at 6-12 months? Hard to tell. I’m just scared that the reason the drop is so big is up regulation of androgen receptors and the speeding up of hair loss or something like that.

    I personally just bought 10g of CB and will mix it in just an ethanol vehicle since the patent says it is highly soluble in alcohol. Or would it be better to do ethanol/PG. What is the difference? My CB is in the mail now and I will keep you updated with results.

    Regarding your CB experience. How long did you use it for and what dose? I don’t think you specified.

      1. What is the difference between a straight ethanol vehicle vs combining the ethanol with other things like PG? I’d like to use just straight ethanol due to convenience. I will likely be making daily batches just to avoid any degradation.

        Also how long were you on CB and at what dosage?

        Once it arrives I’m going to try it as a monotherapy option for couple months so I can accurately gauge my response it.

          1. If i wanted to mix 50mg of CB into 1ml, how many ml of ethanol and how many ml of PG would i use for the 5% solution?

    1. Kirk, Bryan and others that’s have tried Cb, can you please come back and state your results and any side effects you may have had?
      Derek, I’m having a tough time finding feedback about CB sides. Has anyone reported any sides from using CB yet?

  4. With ru, you were using 50 mg, but with cb you were using 150 to 200 mg?? Is it because ru58841 is alot stronger of a compound than that of cb0301?

      1. With ru, the amount needed for effectiveness is 2.5 grams with a 50 ml solution that does allow for penetration, in the cb0301 the studies show, 7.5 solution which equates to 3.75 grams of cb0301, if one were to just mix that 3.75 grams with a 50ml of k and b solution and played around with the dosage amounts, would that be a solid amount of mixture for results if one does respond to antiandrogens, dont wanna waste essential 500 dollars to end up using the compound in the wrong manner for my research. Thanks again for your time and information derek!

        1. 3.75 grams mixed in a 50 mL K&B solution, or another vehicle (Ethanol and PG works fine too), would be a 7.5% solution and would be sufficient imo. Dose is individual dependent though man, just because a study says one thing, doesn’t mean you need that exact amount.

  5. Hey Derek, have you tried any of the peptides designed to promote hair growth like GHK-Cu? if so, what are thought on them?

    1. I’ve tried all the GHRP’s, GHRH’s, and a myriad of other peptides. I’ve never tried GHK-Cu. I prefer GH over pulsatile/bleed peptides.

  6. not all you wrote here is right….my researches has shown that cb is a much stronger weapon against hairloss than ru58841…
    i bought cb before from wuhan, used it at 8% bid, slowed hairloss down about 30 %…i bought cb from kane only use 3 % and no hairloss anymore…think both sources are legit and are 98>% cb0301, but it depends how they synthesize it, and even from the same company, eatch batch can be different strong….sides can occur or also not….
    i use minox and fin too,think that’s also a reason why my lotion don’t have to be more than 3 % to work fine……
    maybee somebody here use cb less than 3 % with sucess…?….

    1. What I wrote is based on my experience and clinical data. There is nothing “incorrect” about what I wrote, it is subjective based on my opinion. If you got good results using only 3% then that’s great. Doesn’t mean every one else will have the same experience as you. You’re also using Finasteride and Minoxidil, so clearly there are some major interfering variables in your assessment.

  7. Hey Derek,

    Thank you for your videos, I wondered if I you could clarify something about the affinity of RU. You mentioned in your video that you have had really good results from the compound but that your results could also be down to your personal experience. From the research you have read and your own opinion how likely are people to achieve similar results. Are there people in which RU does not effect and are there any permanent side effects one should consider when taking RU?

    I am considering using a topical anti-androgen along with Finasteride which I have been on for a month and I am considering using CB or RU. My APA is progressive but not aggressive, I am currently a Norwood 2 with small signs of thinning. How could someone start using RU slowly enough to notice if they would suffer from side effects and if the compound is an effective solution?


  8. Hey Derek,

    Thanks so much for posting this – I’ve recently been in full stress mode because of mpb and have found your website to be really informative!

    Question: I’m gonna take the plunge in trying CB-03-01 (happy to keep a log and share results), although I have never purchased a raw ingredient where I have to mix with something in order to use. I see that Anagenic has a K&B solution where I’ve read I can mix CB with, but would you mind briefly explaining that process? Do I just dump the CB powder in the bottle ?
    Also, is there another standalone vehicle solution you’d recommend I mix with?

  9. Hey Derek, I also get chest issues when using RU. Unfortunately even a light single spray on the scalp makes
    My chest feel heavy and hard to breathe for hours… I expect this is uncommon but still I saw another post on here about another users similar experience.

    I wanted to make a CB solution and can use KB, I wanted to ask how do I know how many mg is in the 2.5/5/7.5% mix respectively? I’ve not brewed before , this will be my first attempt.

    1. Branden can you please offer us feedback? You mentioned you did have chest pains on Ru. Any chest pains with CB?

  10. Derek, the phase II dosing study showed that by the 6 month point, CB works as well as finasteride does in a year, however after 6 months is stops working.

    Do you have any idea why and how the diminishing returns might be avoided?

    Some people think it might be due to AR upregulation. If so, do you think cycling off CB and then back might be a way to avoid inducing upregulation?

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