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Ostarine Results Before And After Picture

Ostarine (MK-2866; Enobosarm) – Results, Clinical Trials & Reviews

Ostarine is the most well known and extensively studied selective androgen receptor modulator (SARM) right now.

It is categorized as a SARM because of its unique selectivity at the androgen receptor where it exhibits a significant amount of anabolic activity in the body relative to androgenic activity.

It is being researched to determine if it is a potential treatment for the management of muscle and bone wasting diseases.

This article covers Ostarine's potential therapeutic applications, dosages, side effects, and anecdotal findings based on my own personal research.

What Is Ostarine? 

Ostarine, also known as Enobosarm, GTx-024 and MK-2866, is a selective androgen receptor modulator (SARM).

SARMs, like Ostarine, stimulate androgen receptors in a selective way, whereby they induce a significantly greater amount of anabolic activity in the body relative to androgenic activity [R].

Testosterone was the first anabolic androgen to be approved for use in a clinical setting,  however, its scope of versatility has always been severely limited by its androgenicity and its pharmacokinetic issues.

Most notable being its lack of selectivity for muscle tissue to other androgen affected tissues like the prostate, and not being orally bioavailable [R].

Testosterone has a 2:1 selectivity for muscle to prostate [R].

Testosterone exhibits a two to one selectivity of muscle tissue to prostate

This lack of selectivity disqualifies Testosterone entirely in a clinical setting for treating women, as well as men in many scenarios, due to the significant androgenic activity that would occur at a systemic level during the attempted management of muscle or bone wasting diseases.

This is where SARMs like Ostarine display such promise as viable alternatives [R].

The ideal anabolic agent should demonstrate anabolic selectivity in muscle and bone without suppressing luteinizing hormone (LH), not negatively interact with other steroid receptors in the body, exhibit a high level of oral bioavailability without being 17 alpha-alkylated, and avoid 5-alpha reduction to DHT and aromatization into Estrogen [R].

SARMs were first discovered in 1998, following which several different compounds were developed by a variety of pharmaceutical companies in order to find a viable compound to satisfy this obvious need in degenerative disease treatment [R].

Ostarine's Mechanism Of Action

By exhibiting such a favorable selectivity for stimulating increases in muscle tissue and strength relative to androgenic activity in affected tissues, Ostarine has the potential advantage that it could be used at relatively low doses, is orally bioavailable, and could potentially circumvent some of the negative effects that stem from traditionally used anabolic Steroids converting to 5α-reduced androgens in modern medicine that may raise the risk of benign prostate hyperplasia, accelerate the development of prostate carcinoma, increase the probability of acne breakouts, and exacerbate/substantially expedite androgenic alopecia (male pattern baldness).

It could also potentially eliminate the incidence of androgenic side effects in women entirely, while still potentially inducing enough anabolic activity to offset any muscle or bone loss occurring from degenerative disease.

While this is beneficial for both men and woman, its lack of androgenicity in women makes this a very promising anabolic agent.

Even minor amounts of androgens can cause virilization, making it extremely difficult to find compounds potent enough to offset degenerative diseases with no side effects in women.

Not only does Ostarine increase muscle mass and strength, it increases tendon strength, ligament health, bone density and encourages collagen turn-over [R, R].

Ostarine Vs Placebo Change In Lean Body Mass
Percentage change of lean body mass from baseline to end of study

It also has good oral bioavailability [R].

This makes oral dosing viable as opposed to intramuscular injection with traditional anabolic steroids (an obviously less practical method of medicinal intervention), or oral dosing with 17 alpha-alkylated anabolic steroids that are liver toxic and require a methyl or ethyl group, at the C17α position to be orally bioavailable.

Ostarine was the closest SARM to making it through clinical trials and being approved.

Ostarine Clinical Trials

Enobosarm (Ostarine) Pipeline
Enobosarm (Ostarine) Pipeline

Ostarine was the first drug to be put on the FDA's fast track development program to become an approved drug for the prevention and treatment of muscle wasting in patients with cancer.

In mid 2013, GTx announced that Ostarine had failed its late-stage phase III trials as a lung cancer drug intended to prevent muscle wasting [R].

In these trials, 325 patients were given 3 mg of Ostarine per day, or placebo (randomized trial), to assess if Ostarine would significantly prevent muscle loss in those who received the 3 mg dosage, vs those that didn't.

Power during a stair climb test was also used as a measure to assess improvements in physical function.

Secondary endpoints included an assessment of whether patients who were treated with Ostarine had any improvement in their quality of life, or if they required less healthcare resources than the placebo group.

While the trial was a failure overall, the positive takeaway was that Enobosarm (Ostarine) demonstrated significant quantitative advantage in LBM (lean body mass) compared to placebo in both trials [R].

In layman's terms, Ostarine on average increased or maintained a significantly greater amount of muscle mass in the patients that were treated with it, relative to those who were treated with placebo.

Following that, in 2016 GTx started a phase II clinical trial to assess Ostarine's viability as a stress urinary incontinence treatment for women. 

The results of that did not achieve statistical significance [R].

Looking at the results of Ostarine in totality across all of its clinical trials, we can make a more educated assessment on its viability for the purposes of selective increases in muscle mass relative to androgenic activity.

Ostarine has been evaluated in 27 completed or ongoing clinical trials.

About 1500 subjects in total have been treated with Ostarine in some capacity, with dosages ranging from as low as 0.1 mg all the way up to 100 mg.

Ostarine was observed to be generally safe and well tolerated in all of those trials.

One notable Phase 2 clinical trial that evaluated Ostarine as a form of hormonal therapy for women with estrogen receptor positive (ER+) and androgen receptor positive (AR+) breast cancer was broken down into two dose cohorts (9 mg and 18 mg daily).

The Phase 2 trial pre-specified threshold for success, clinical benefit response (CBR), was attained meeting the trial’s primary efficacy endpoint.

The trial enrolled the predefined number of evaluable patients in both dosage arms with at least 44 patients in each of two cohorts receiving 9 mg or 18 mg daily doses of Ostarine (Enobosarm) respectively [R, R].

This study in particular presented the first opportunity for us to gather clinical data representing what results would occur from what would generally be considered “high dosages” of Ostarine.

My Ostarine Experience

I first experimented with Ostarine back in 2014.

Back then, I would bridge between Steroid cycles, and use a low dose of testosterone to maintain high-normal physiological test levels year round.

I experimented with countless different approaches during my bulking and cutting phases over the years, and one of the things I wanted to try at the time was a cut phase immediately after my off-season to regain my insulin sensitivity so I could start bulking again.

My bulk phase was going very well back in 2014, but it was abruptly cut short when I experienced an injury to my leg that required immediate surgery.

I was extremely annoyed to say the least because I had to cut my off-season short mid-way through it.

I wasn’t content with what I had gained during that off-season, and my lack of adherence to a strict diet after my surgery, as well as my inability to do any lifting or cardio both took a toll on my physique.

Not only was my insulin sensitivity in the toilet, my body fat percentage was too high to justify jumping back into a bulk phase right away after I recovered from surgery as I was simply too fat.

My compromise to myself was to start a mini diet just to get back under 10% body fat, regain my insulin sensitivity, and then continue my off-season that was cut short by surgery.

As I was only using a low dose of testosterone during my surgery and recovery phase, I didn’t want use any harsh compounds or high dosages just to cut down to 10% body fat when I was trying to give my body a break and prime it for a bulk phase where I would actually use a strong combination of anabolics.

A friend of mine suggested I introduce a SARM into my regimen to help me preserve muscle during my cut phase as I bridged between my two bulk phases post-surgery.

He told me about his results using Ostarine, and I did a bit more research and decided to give it a go.

My Ostarine Results And Review

The goal for this mini-diet was to lose as much body fat as possible, or at least get into the sub 9-10% range without losing any lean muscle mass, while using minimal performance enhancing drugs.

To be frank, I did just that.

Ostarine Cutting Results Day 1
Day 1
Ostarine Cutting Results Week 1
Week 1
Ostarine Cutting Results Week 2
Week 2
Ostarine Cutting Results Week 3
Week 3
Ostarine Cutting Results Week 5
Week 5
My Ostarine Results After 6 Weeks
Week 6

The mini-cut was really successful and it put me in a good spot to start my bulk back up in a much better position relative to my body composition after the mini-diet.

I lost no strength and I didn’t lose any lean muscle tissue.

I was able to drop down to approximately 8-9% body fat with only 3 cardio sessions per week for about 25-30 minutes a piece at my most involved portion of the cut which took 6 weeks.

The Ostarine definitely kept me harder and stronger than I would’ve been had I simply opted to cut down on a small amount of testosterone.

I actually gained a few reps on a few of my compound lifts during that mini-cut, which is abnormal to occur in a calorie deficit.

Needless to say, I was no longer a hater on SARMS.

Is Ostarine As Strong As Steroids?

While Ostarine did help me reach my goal I set for myself, I absolutely do not think that it is as strong as most steroids are (in certain contexts).

However, I think it does have the ability to match the same level of anabolic activity that moderate doses of certain “milder” steroids provide.

Anavar and Primobolan come to mind when I think of good steroids to compare the results to.

With Ostarine displaying a blatant dose dependent increase in muscle mass, it would be desirable to investigate where the point of diminishing returns is in humans with regards to increases in lean muscle mass, as dosages as low as 10-25 mg of Ostarine are commonly compared to 50-100 mg dosages of traditional anabolic androgenic steroids, which is obviously a ridiculous way to assess overall potency relative to one another.

10 mg of Ostarine will outperform 10 mg of Anavar, Turinabol, Primobolan, Equipoise, and many other traditional anabolic steroids, with a favorable selectivity for anabolic:androgenic activity, and less endocrine suppression.

Ostarine Vs Nandrolone

Milligram:Milligram, Ostarine is multiple times more effective at increasing lean muscle mass than Nandrolone, a very commonly used anabolic androgenic steroid.

More commonly known as “Deca” (Nandrolone with the Decanoate ester) or “NPP” (Nandrolone with the phenylpropionate ester). 

Ostarine Vs Nandrolone % Increase In Lean Muscle Mass
1) Change in LBM at 6 months in hip fracture patients. 2) Myostatin antibody. Change in LBM at 12 weeks in older weak fallers. 3) Change in LBM at 12 weeks in men and women >60 yrs old.

Ostarine Vs Anavar

I truly believe that Ostarine is stronger than Anavar now.

When I first started experimenting with SARMs, I was hesitant to imply that it could be as strong as any anabolic steroid that has a notable androgenic effect in the body, as I simply did not think it would be possible to stack up against any of them.

Throughout countless anecdotal experiences now, I have personally seen Ostarine mg:mg outperform Anavar in terms of sheer muscle and strength increases, as well as in terms of side effects.

Ostarine is less suppressive than Anavar, outperforms it in an anabolic capacity, and displays a significantly lower incidence of side effects and androgenic activity in the body.

For women especially, after seeing multiple women try Anavar and Ostarine on separate occasions, Ostarine always outperformed the Anavar and appears to clearly be the candidate of choice when it comes to performance enhancement.

How Ostarine Stacks Up Against Other SARMs

Ostarine has the most clinical data available, so one would generally jump to the conclusion that it is the best overall SARM, however, I feel that is not necessarily the case and should be explored further.

Ostarine Vs LGD-4033

While Ostarine exhibits a blatantly favorable selectivity for muscle tissue to prostate (and other androgen affected tissues), in comparison to LGD-4033 it is outperformed in almost all aspects.

Milligram:Milligram LGD-4033 (VK5211) outperforms Ostarine (Enobosarm) with greater increases in lean muscle mass and strength.

Despite LGD-4033 being more potent, Ostarine is less suppressive, which would make recovering natural testosterone levels a smoother and quicker process after discontinuation.

LGD-4033 Vs Ostarine % Improvement In Muscle Mass
1) Change in LBM at 6 months in hip fracture patients. 2) Myostatin antibody. Change in LBM at 12 weeks in older weak fallers. 3) Change in LBM at 12 weeks in men and women >60 yrs old.

Ostarine Vs S4 (Andarine)

Ostarine's effect on muscle tissue and overall body composition is most similar to Andarine (also called GTx-007, S-4).

Milligram:Milligram, Ostarine is stronger than S4 for building lean muscle mass, however, it does not seem to have the same cosmetic drying out effect of the physique that S4 provides.

Ostarine also has the obvious advantage of not binding to the ocular receptors in the eyes, which is the biggest detriment to S4's potential applications, whereby it causes notable vision impairment in dark settings.

S4 however has less of a detriment to HDL cholesterol levels than Ostarine.

Ostarine and S4 are reported to have great synergy with one another when used concurrently, with several users accomplishing very impressive body composition transformations with the combination.

Ostarine Vs S-1

Ostarine is commonly mistaken as S-1, but it should be noted that (S)-3-(4-chloro-3-fluorophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide (C-6), also called S-1 was one of the earliest SARMs developed, and is far weaker than Ostarine [R].

Ostarine Dosage

Predictably, Ostarine caught the attention of the bodybuilding industry with its impressive pre-clinical profile and blatant potential advantages in a performance enhancement context.

While Ostarine was initially trialed at 0.1 mg, 0.3 mg, 1 mg, and 3 mg per day, it is not well known that dosages of 9 mg and 18 mg per day were generally well tolerated by women in a less commonly known phase II clinical trial [RR, R].

Lean gains upwards of 5 – 10 pounds are typical among recreational users, with average dosages ranging from 10 – 25 mg per day.

These dosages were determined by recreational users based upon anecdotal logs and personal experimentation, and are not concrete guidelines that dictate correct or incorrect use.

Ostarine Side Effects

Decreased Good Cholesterol (HDL)

The clinical data on this is inconsistent as there are some studies that show reductions in serum lipids (namely HDL and LDL) occurring in a dose dependent manner with Ostarine usage, as well as data showing only reductions in HDL levels (otherwise known as “good cholesterol”) [R, R].

We at least know for sure that Ostarine has a negative effect on HDL levels, which is notable as this is a common side effect of all traditional anabolic steroids, and other SARMs.

Despite SARMs ability to avoid significant androgenic activity in the body, they evidently do not differ much from anabolic steroids in their effects on lipid profiles.

Testosterone Suppression 

SARMs have shown to suppress luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis, thus decreasing testosterone in a dose-dependent manner [R].

Ostarine has also shown to significantly lower Sex Hormone-Binding Globulin (SHBG) and serum total testosterone levels in clinical trials in subjects treated with 1 mg of Ostarine or higher [R].

While SHBG was always significantly impacted at notable dosages, suppression of LH and FSH wasn't consistently proven throughout Ostarine's clinical trials.

However, after referencing anecdotal logs of baseline pre-Ostarine blood work compared to mid-Ostarine blood work with dosages several times higher than the 0.1 mg, 0.3 mg, 1 mg, 3 mg dosages used in trials (users commonly use Ostarine at upwards of 25 mg per day for several months), I believe it's safe to say that Ostarine does also show blatant reductions in all of these hormones markers in a dose dependent manner, the dosages in the studies just weren't high enough to yield this data.

The degree to which even high dosages of Ostarine suppress LH and FSH is far less than that of traditional anabolic steroids though, which should be noted.

The process of recovering to baseline healthy endocrine function would be hindered to a far greater extent in steroid users.

Elevated Estrogen Or Decreased Estrogen

Ostarine does not aromatize into Estrogen directly, however, via the suppression of natural Testosterone levels, it can create an unfavorable balance between Testosterone and Estrogen in the body.

In addition, by occupying the androgen receptor with such a high affinity, Ostarine can actually divert a significant amount of Testosterone to aromatize into Estrogen that wouldn't have otherwise.

This in turn, can create an elevation of Estrogen levels in the body, which is commonly mistaken as the compound being laced with prohormones, or being an anabolic steroid.

Common symptoms of high estrogen include:

  • Acne, oily skin
  • Erectile dysfunction
  • Low libido
  • Lethargy
  • Gynecomastia (man boobs)
  • Irritability
  • Depression
  • Water retention
  • High blood pressure
  • Enlarged prostate
  • Shrunken testicles
  • Sugar cravings

While Ostarine can cause an elevation in Estrogen via the increased aromatization of circulating Testosterone, long-term use, or high dosages of Ostarine can cause an opposite effect, where the body has such a low level of circulating Testosterone via endocrine suppression that you no longer have enough aromatization occurring in the body, leading to an array of health problems derived from the lack of Estrogen needed to fulfill certain physiological functions.

Common symptoms of low estrogen include:

  • Dull weak orgasms
  • Dry skin and lips
  • Dehydration
  • Erectile dysfunction
  • Low libido
  • Irritability
  • Mood swings
  • Loss of appetite
  • Fatigue
  • Lethargy

Applications In Alternative Hormone Replacement Therapy In Men

As Ostarine does not aromatize into Estrogen, it disqualifies it as a viable form of standalone hormone replacement therapy in men.

A variety of basic physiological functions in men rely on the aromatization of Testosterone into Estrogen, as low Estrogen side effects can be just as harmful to one's health as high Estrogen side effects.

In hypothetical long-term HRT applications, Ostarine would likely need to be used in conjunction with exogenous Estrogen to maintain in range blood serum concentrations to fulfill basic physiological functions that otherwise would be dependent on the body's endogenous aromatization of Testosterone to Estrogen.

Androgenic Activity

Ostarine has a dose dependent increase in androgen activity in the body.

While it is extremely selective for muscle and bone relative to androgen affected tissues, all SARMs (Ostarine included) display a systemic increase in androgen activity, hence there is still potential for androgen related side effects, just to a far lesser extent.

The ratio of anabolic:androgenic activity is favorable enough whereby the therapeutic dose necessary to yield the desired level of muscle retention and bone mass would ideally not be high enough where any notable androgenic activity could take place, and that the drug would still be generally well tolerated with a great safety profile.

Establishing the balance between all of these factors is the reason why no SARM has yet been approved for human use, as it is very difficult to develop a compound with a substantial amount of anabolic activity, with a near complete absence of androgenic activity.

Hair Loss

All androgens can cause hair follicle miniaturization, the extent to which they do this is dependent on their individual selectivity, binding affinity, and the dosage used.

In general, Ostarine (at the dosages commonly used) would not cause any notable androgenic alopecia.

However, this does not exclude temporary shedding caused by a hormonal fluctuation.

Anything that causes a hormonal fluctuation in the body, can potentially cause a temporary shed.

This is not to be confused with androgenic alopecia, but it is hair loss nonetheless, albeit temporary.

Liver Toxicity

Short-lived increases in ALT to above the upper limit of normal were observed in eight subjects in one of Ostarine's clinical trials.

The ALT observations in seven of eight subjects had resolved while still continuing their daily dosage, and no subject had clinically significant abnormal levels of ALT or AST at the end of study.

One subject was discontinued due to an elevation in ALT 4.2 times the upper limit of normal.

The ALT level in that subject returned to normal levels after discontinuation of the Ostarine [R].

This was with dosages of no higher than 3 mg per day, so it is only logical to assume that common recreational dosages of Osatarine (upwards of 25 mg) may exhibit some level of liver enzyme elevation.

This is contradictory to common broscience theories that assert that there is zero chance of liver toxicity from SARMs at any dosage amount, or that an increase in ALT in their blood work must mean that they received methylated prohormones instead of SARMs.

At therapeutic dosages, there appears to be a low risk profile, but it should be noted that there may be some notable degree of liver toxicity at dosages commonly used for performance enhancement, which would likely resolve itself after cycling off.

Lack Of Aromatization And 5-Alpha Reduction

Ostarine does not aromatize or create a layer of subcutaneous water retention.

Increases in lean muscle mass are absent of artificially inflated water weight, not only making the SARM favorable from a cosmetic standpoint in a clinical setting, but also from a health standpoint, as water retention induced from previously approved anabolic androgenic steroids like Anadrol can often lead to increased cardiovascular stress, increased heart rate and blood pressure, electrolyte imbalances, among a myriad of other issues.

More importantly, the lack of aromatization limits potential side effects that could occur from aromatization from traditional anabolic steroids like Testosterone.

Ostarine does not undergo 5-alpha reduction, which is speculated to contribute to its sparing effect on the prostate and other androgen related tissue.

This is not the case though, as there are several androgens that do not undergo conversion to a more androgenic compound when they hit 5α-Reductase.

One of the most notable being MENT (Trestolone).

In fact, some androgens are more androgenic prior to 5-alpha reduction, and present an increase in androgenic side effects when they are inhibited with 5-alpha reductase inhibitors like Finasteride or Dutasteride.

An example of this is Nandrolone.

Effect of a 5α-Reductase inhibitor on the androgenic activity of Testosterone, Nandrolone and MENT (Trestolone) in castrated rats.

Ostarine is inherently selective for the androgen receptor, and its selectivity for muscle tissue and bone relative to androgen affected tissues like prostate is not a result of its inability to be altered by 5-alpha reductase.

Half-Life 

Ostarine has a half-life of 23.8 hours, making once per day dosing a viable option for maintaining stable blood serum concentrations [R].

Ostarine Bulking Cycle

In a calorie surplus Ostarine will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

MK-677 (Ibutamoren) and/or S4 are commonly stacked alongside Ostarine in more involving performance enhancement bulking protocols.

Ostarine Cutting Cycle

In a calorie deficit Ostarine will retain much more lean muscle mass than would otherwise be possible naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user's individual timeline constraints for reaching a goal body fat percentage).

Cardarine (GW501516) and/or S4 are commonly stacked alongside Ostarine in more involving performance enhancement cutting protocols.

Ostarine PCT (Post Cycle Therapy)

Ostarine will suppress natural Testosterone levels (and overall endocrine function) in a dose dependent manner.

It is wise to complete a PCT phase (post-cycle therapy) after an Ostarine cycle.

Due to Ostarine's half-life, PCT should be started the day after the last Ostarine dosage was taken.

Forgoing PCT will put one at risk of muscle loss, fat gain, among all of the other standard side effects associated with Testosterone suppression.

If you are dead set on using performance enhancing drugs shortly after Ostarine, I would not advise following the broscience derived “time on = time off” equation.

Time off should be dictated by a variety of more individual specific factors, and blood work.

Buy Ostarine

Most Ostarine sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I highly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure Ostarine:

Proven Peptides – 10% off coupon code “DC10”

Science.bio – 10% off coupon code “DC10”

Chemyo – 10% off coupon code “DC10”

Narrows Labs – 25% off coupon code “DC25”

Swiss Chems – 11% off coupon code “DC11”

Androbolics Canada (CAD Currency)

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

86 thoughts on “Ostarine (MK-2866; Enobosarm) – Results, Clinical Trials & Reviews”

  1. Would you take the RED PCT alongside the Ostarine or wait until after coming off of Osta?

    What supplements and dosages would you use during the PCT?

    1. I would wait until your last dose of Ostarine is taken, then start the PCT immediately the day after. However, if you are noticing estrogen side effects during your Ostarine cycle (libido hitting the shitter, erectile dysfunction, etc.) then you would benefit to use the RED-PCT DURING your cycle as well alongside the Osta. It will help offset the estrogen side effects if you are prone to them (rare, but it happens).

      During PCT I would use the recommended dose on the bottle.

      For supplements during PCT alongside RED-PCT I highly recommend D-Aspartic Acid (DAA). It’s not 100% necessary, but it certainly will help boost your testosterone a decent amount which in conjunction with the RED-PCT is a very good combo for getting yourself back to 100% as quick as possible and keeping all your Ostarine gains. I usually use SD pharma for my singular ingredient products like DAA. I linked it below for you if you choose to pick it up. It’s probably one of the only natural test boosters I would recommend.

      http://amzn.to/2gdUycy

  2. I enjoyed your review, I’ve been looking at Ostarine for a while now. I’m not a competitive bodybuilder at all… I’m more of a lanky basketball player. I’ve been looking for a supplement that will help me add some lean muscle (not too much, about 10 pounds) cut a little more fat off and help my left knee recover a little more from a minor injury. From all that I’ve read on Ostarine, it seems to fit as closely to that as anything.

    But since I am inexperienced with anabolics I wanted to fully research it, make sure I use it and diet properly, and workout at a good rate when I cycle through it. My one question is, does Ostarine allow you to increase the rate at which you workout (i.e. work out more days per week) the way I’ve heard steroids can? Again, I’m new to this stuff and that’s possible a noob question, but I just want to prepare myself to get the most out of it. Since it’s relatively mild, the risks are still low, but I want to use it as properly as I can.

    I appreciate your help. Thanks for all the info!

    1. Hey Dave, thank you for the kind words.

      Yes, this would be a great supplement choice to help you reach your goals. 10 pounds is a very realistic expectation from Osta-Red with a sufficient diet and training regimen, with zero-minimal side effects, as well as the benefit of improved tendon strength, ligament health, bone density and collagen turn-over to promote the healing process of your knee.

      To answer your question, yes it will increase your recovery ability during your workouts, so you will get fatigued less easily by your training, consequently being less sore, allowing you to be able to train more frequently at a higher intensity and higher strength level.

    1. Thanks brother 🙂 Ya I’m almost always on a very low dose of hrt regardless of what I’m doing. I do cycle off completely once in a while though as I believe the time off helps

  3. Hey Derek, I’m 10 weeks into the GLL fat loss diet (~180lbs) and I’m almost 20 years old. Should I use ostarine or am I too young?

  4. Hey man I took the first batch of osta red even before the pct was out, after getting off I didn’t take a pct and I feel like it has messed me up with erections etc. Now this was months ago but I still feel this way. What should I do? I think I’m going to get my test lvls checked out.

    1. Ya you should always have a PCT lined up, even if it isn’t the RED-PCT product, you should have something for the end of each SARM cycle. Go get blood work done and see where your test and estrogen levels lie, then you can proceed accordingly from there. I anticipate that you will just need to complete a normal PCT phase still to return back to hormonal homeostasis.

  5. Great post man, im interested in this but not for the muscle building properties per se. Im more interested for the joint/tendon healing properties. What would yo say is a good dose to get the healing benefits without so much the anabolic effect (if it makes any sense).

    Thanks man.

  6. Hello is novadex needed at a 4 weeks cycle? and also i heard ADD isnt a sufficent after a sarm cycle is this true?

    1. I highly doubt it.

      And for ADD, it is an ingredient that is great to have in your PCT product, and will suffice for milder SARM cycles that aren’t several months in duration.

  7. Hello Derek!
    Great Article!

    I will soon do My first sarm cycle and i’am looking at the kirby bulk stack from EA,but there is no pct included just their Blue ox test booster that goes with the stack. Do i need anything more for pct? I Will dose 20mg ostamuscle for 8 weeks.

    1. Ostarine is very mild suppression wise, so the Blue ox test booster used post cycle at the full dose for 4 weeks should suffice.

      1. Thanks for reply 🙂

        would this be best for My first cycle? Im currently in a heavy bulk phase and read that lgd is the best bulker. Should i jump right into lgd or Start with something milder like the ostamuscle ?

      2. Hey can you use osta muscle a pct and blue ox all together and when you get of the ostamuscle how long would you continue to use the pct or blue ox

        1. I wouldn’t recommend using suppressive SARMs at all during PCT, my stance that I took in this post almost 2 years ago regarding the low dose Osta during PCT has changed and I would no longer advise it.

      1. Cool, thanks. One more question for you if you dont mind. In terms of relative strength gains(gains in strength compared to size) which is better ostarine or lgd? I know lgd puts more mass on people but which one puts on more strength per lb of mass gained?

      2. Hi Derek, thanks for sharing your Ostarine experience. As a first time 45 year old Os user I went at 9,5mg (week1), 12,5mg(week 2), 15mg (week 3), 17.5mg(week 4), 20mg( week 5), 12,5mg(week 6). I quite honestly had no strength increase at all, I did however pick up 3.5lbs despite not changing diet at all. All gains were 100% clean without any bloat. I have been off for 2 weeks and gains have remained, not on any pct and erections are all good… just my 10c for other users who are guessing on dosages/outcomes.

  8. Hey love your blog and channel I’m looking to try sarms for the first time, ostarine and cardarine . I am from the uk and have found a site that distributes Alphaform lab products. Do you think this source is reliable ? Please could you reply in an email thank you for your time.

  9. Please, im need dosing and timing to PCT.
    I need the dose and duration of the PCT and which product to do it

    1. For an Ostarine only cycle, Arimistane should be sufficient.

      3 pills per day for 4 weeks post-cycle.

      There are two Arimistane products I like:

      RED-PCT is one of them

      and Arimi-RX is the other one (discount code “DC15” will get you 15% off at checkout for Arimi-RX).

  10. Hey Derek,

    What compounds would you recommend for someone wanting to have the most endurance, strength and speed for their weight class in jiu jitsu? I wouldnt mind gaining some size and going up in weight as long as those attributes all increase relatively more so.

    Thanks!

  11. Hey Derek,

    Enjoy your content, have a question.

    I am decently lean 9-11% bf, going for my first cycle, need 8-10 pounds of muscle (lean if possible).
    If you are in my place, would you do solo ostarine cycle, or solo mk 677, or stack ostarine with mk 677?

    Ty in advance.

    1. If you are set on Ostarine then ya Osta + MK-677 would be good for your goals if you can keep your diet tight and not overeat.

      1. Currently I’m on doctor prescribed TRT. With that being said, is a PCT even needed upon the completion of an Ostarine cycle? Also, what would be an optimal time to run another Ostarine cycle after the initial one is completed?

          1. I wanted to ask is Arimi-RX PCT enough for the Ostarine + mk 677 stack? and how much weeks should i take it?

            Ty

  12. Hey Derek,

    I just started a cut and was wondering if Ostarine would be a great sarm to add to my cut to help with maintaining muscle mass. Overall I’m trying to bring my bodyfat to the 10%-12% area and I’m at a starting weight of 173 and around 18-22% body fat.

  13. Hi Derek,

    I would like to run Ostarine with Cardarine for recomp cycle. Ostarine for 4 weeks at the recommended dosage of 10ml or 12ml then Cardarine for 12 weeks. Would it be beneficial to run Ostarine for 6 weeks or is 4 weeks long enough? As far as PCT goes, I’ll run your recommended ArimRX and DAA for 4 weeks, what are you’re thoughts on this cycle?

    1. 4 weeks is way too short of a cycle to expect to gain any appreciable amount of muscle mass. Building new slabs of muscle tissue is a slow process, you won’t gain much of anything from a 4 week cycle except a bunch of temporary glycogen/nitrogen retention. Some muscle sure, but not very much at all.

      The “recommended dose” isn’t 10-12ml either… I’m not even sure what you mean by that. I don’t think a male should bother using less than 20mg tbh.

  14. Thanks Derek,

    Guess i’ll run 20-30mg for 6 weeks (Would running it 8 weeks be ok also). I’ve never used PED’s in my life so I’m hoping putting these new compounds in my system might produce better some results as in little more mass and leaner look. My diet itself is pretty good and weight training routine is pretty good also, 5 days a week….just hoping to lose some bodyfat running it alongside Cardarine along with 1-2 pills of Blue Ox on Cycle.

    Would you suggest running MK677 with ArimRX as a post cycle be beneficial.

    1. 8 weeks is better than 6. MK-677 is always beneficial unless you are trying to cut down because it will typically make you overeat.

  15. Question for you Derek,

    I want to stay as natural as I possibly can by just taking Ostarine and cardarine and none of the other harsher compounds. If I go on Ostarine for 8 weeks, come off for a month or two, then start up Ostarine again, will I keep on gaining muscle mass, provided I eat over maintenance, eat clean, and workout hard. Will my body get use to the Ostarine, making it harder to gain thus I’ll have to add other compounds like s4, Rad140, etc…. I want to avoid the harsher compounds as much as I can, but will Ostarine ultimately stop at some point and I’ll have to add the other harsher compounds?

    1. Eventually if you want to keep making progress you will have to eat more/up the dose/add other compounds. It’s not like you can get to 300 pounds on Ostarine only. It doesn’t work that way.

  16. Sup Derek,

    My Cardarine and Ostarine came in the mail today, so I’m ready to start but I’d like some advice from you before I start it as I’m new to SARMS so this will be my very first cycle.
    Here’s my plan:

    Week 1 ( 20mg Ostarine, /20 mg of Cardarine, /2 capsules of Blue Ox (at night)
    (I have Arimistine on hand just in case of any estrogen side effects)

    week 2 (20 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 3 (20 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 4 (20 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 5 (20 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 6 (30 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 7 (30 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 8 (30 mg Ostarine, 20 mg of Cardarine/ 2 capsules of Blue Ox)

    Week 9-12 (PCT) (Arim-RX 3 capsoles a day, 3 capsoles of D-Aspartic Acid 1500mg) (Maybe 10mg of MK677 as well)

    Any information you can help me would be greatly appreciated…keep up the great videos brother!!

  17. Sup Derek,

    After my Ostarine, cardarine and Post Cycle are finished…I wanted to take month off and start doing a 6 week Arimistine cycle only (Starting off at 100mg then tapering off each week to 75mg then 25mg. Would I need a post cycle for Arimistine only cycle?

  18. Hi Derek,

    For someone on HRT, how long would you recommend waiting between cycles? From my understanding, the PCT phase becomes unnecessary, but there is still some desensitization that occurs.

    Thanks for the site, lots of great content on here.

    1. There is no set time limit. These are research chemicals. You should give your body a break once and a while, but there is no set in stone cruise time where you should stay before you are able to make gains again.

      Some IFBB pros blast 11 months per year and cruise for 1. Some blast only for 3-6 months prior to a show. Ultimately, it is a personal decision that you must decide for yourself.

  19. Hi Derek, I’m on the last few days of week 3 on a week 8 Ostarine and Cardarine Cycle. I’ve been dosing it at 20mg per day. During the first 2 weeks, my muscles were pretty hard all day long, but on week 3, my muscles aren’t as pumped, would it be recommended to bump it up to 30mg per day or just stay with 20mg. I did plan on doing 30mg for the last 3 weeks of my 8 week cycle…What would you suggest?

    1. I wouldn’t run anything less than 25mg as a male anyways. Muscles not being as pumped isn’t an indicator that it isn’t working btw.

  20. Hi Derek,
    I’m sure anyone researching SARMS -Osterine to be specific, appreciate the valuable information you have provided in your article/video as much as i do.
    My wife is looking to gain lower body mass all the while trying to shed some upper body fat without loosing the mass she has already gained. How do you recommend her using SARMS to achieve this goal and over what period of time?
    And do you recommend stacking it with something else like Creatine?
    I appreciate your feedback.
    thank you.

    1. Those are two totally contradictory goals, I’m not a fan of recomposition cycles to be honest. The SARMs she would benefit from are the same that anybody would benefit from, as they are non-androgenic. Take a look through some of my articles and you’ll get an idea of what SARMs do what, and then you can comprise a stack for based on that. I think Ostarine on its own is quite good for women to be honest. LGD-4033 is solid too.

      Creatine is always a staple.

  21. Hi Derek,

    I started using Ostarine afew months ago, wasn’t as effective for me because I wasn’t on the ball for training and diet wise due to busy working schedule. Now I’m more free and is willing to get back onto my 2nd cycle.

    Since my 1st cycle wasn’t proper, I’m giving it another go,

    (Running for a total of 8 weeks)

    Week 1-8 : Ostarine (Pill form 10mg per capsule) 20mg daily
    Week 9-12 : Arim-RX 3 caps a day?

    How’d you think?

    Goal is to get lean,build some muscle mass while im at it.

  22. Hey Derek,

    Love all your informative content on sarms man, keep up the good work!

    My question is If I am taking 10mg of ostarine just for the healing benefits would any on cycle or pct be necessary?

    Thanks!

    1. Probably not, depends on your age and propensity to suppression though, I can’t give you a yes or no answer for sure. A dose that low will not significantly suppress you so it will be a judgment call for you if you want to PCT or not.

  23. I am currently running a low dose of Ostamuscle 10mg ED just to see how my body reacts. I have been noticing some slight gyno (my bf has gone up slightly in the past month before I even touched SARMS) but I notice it more now. I am currently taking 25mg of Arimistane and a milk thistle tab with the ostarine. Should I bump my arimistane dose to 50 ED or would that cause more problems. I do plan to run 20mg ED of ostarine.

  24. Hello Derek,
    I have 1200mg of osta, so I can run:
    60days (8 and 1/2 weeks) on 20mg
    48days (6,8 weeks) on 25mg
    Or something else like 1-5 at 20 and 6-8 at 25. What is the best for bulk?
    Always natty, just want to reach my natural potential faster.
    183cm x 83kg 12%
    Thank you for sharing your experience!

    E.

    1. I’d just do the first option if you are a newbie who has never used anything before and aren’t at your genetical potential yet.

  25. Would a SERM such as Clomid be sufficient for a 4-8 week 25mg cycle of Ostarine? I notice your recommendations of a FULL PCT do not include SERMS, which I thought is a the definition of a full pct.

  26. Hi Derek,

    I have been running my first ever cycle of ostarine at 25mg per day for the last six weeks and I have experienced amazing results and no sides.. apart from one which has only just started. My libido has completely disappeared and I can hardly get an erection.

    I have 30 days left of osta and would love to continue but I also have your pct protocol ready to go. Should I continue and add something to help with libido or finish the cycle and begin pct, saving the osta for a cut in summer?

    What would you advice?

    Thanks in advance.

    1. You likely can’t do anything to fix your libido on cycle, you are suppressed. You’ll have to recover that during PCT. If you continue it or not that’s up to you.

  27. Hey Derek, I am 19 and will be 20 in June. I diet fairly well during the week days and I train in the gym about 3 to 4 days out of the week while I train Brazilian jiu jitsu and boxing about the same days as well. I’m 6’2 and lengthy but kind of a skinny fat. Some muscle mass but fat as well. I’m looking to give ostamuscle a try to hopefully burn some of my fat and maybe add some lean muscle. Will doing this help recover my body from the martial arts I train and should I use any other supplements while on cycle and what all should I use when I get off? Thanks

    1. Anabolics don’t directly burn fat, they put your body in an anabolic environment conducive to packing on tissue in a calorie surplus, or retaining it in a deficit when it would otherwise be lost. If you want to burn fat you need to adjust your caloric intake accordingly. If you are looking to add muscle, then you need to eat enough and forget about fat burning because those are two totally counterproductive goals to one another. Yes Ostarine helps recovery. You need to PCT when you come off. Everything you’d need to know is outlined in this article already.

  28. Hey man I’ve got a few questions.

    1) I am about 12% body fat right now. Would you suggest doing a mini cut to get down to ~9-10% before starting my bulk? Nowhere near my genetic potential right now FWIW.

    2) If I were to use ostarine during said mini-cut, would it be unadvisable to immediately start an LGD/MK-677 with bulk right after it?

    3) Immediately after a cut, should a SARMs cycle be started right away when I go into my bulk? Given that I will lose some muscle mass from the cut, should I wait until I’ve gotten that muscle back before starting the bulk with the SARMs?

  29. Hi derek, is normal to shed hair and litlle bit of eyebrows on Ostarine ? I even use nizoral shampoo and stil experience this on top of that i use just 10mg. This happend to me even on RAD140. Thx.

  30. Hey Derek
    Great info on ur site … been on trt 100mg week want to add ostarine for an extra boost …25mg /day ostarine with my trt sounds good for help bulking as well as joint help? Thanks

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