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LGD-4033 (Ligandrol) – Results, Clinical Trials & Reviews

LGD-4033 is a selective androgen receptor modulator (SARM) currently being researched for its potential applications in the clinical treatment of muscle wasting, osteoporosis and other related conditions.

LGD-4033 is purported to be the most potent SARM currently in clinical trials, with its data exhibiting the most favorable ratio of anabolic activity relative to androgenic activity.

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What Is LGD-4033?

LGD-4033, also known as Ligandrol, was originally developed by Ligand Pharmaceuticals, Inc. and was licensed afterwards to Viking Therapeutics.

It is now officially named VK5211 under Viking Therapeutics.

LGD-4033 is commonly incorrectly referred to as “Anabolicum”, which is actually the brand name for the anabolic androgenic steroid Quinbolone developed by Parke-Davis [R, R].

LGD-4033 is a selective androgen receptor modulator (SARM) developed to be a potential treatment for a variety of musculoskeletal degenerative diseases. 

The main goal of all SARMs essentially boils down to finding the right compound that provides the same therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance.

So far, LGD-4033 has demonstrated an incredible efficacy profile, and the clinical data suggests it could be a best-in-class small molecule SARM.

LGD-4033 Intended Use And Goals

LGD-4033 Potential Clinical Applications

Despite being the endogenous hormone that men naturally produce, Testosterone use in a clinical setting for treating muscle and bone wasting diseases is extremely limited because of its androgenicity and pharmacokinetic issues.

Testosterone is not selective enough for muscle tissue and bone relative to other androgen affected tissues like the prostate, and is not orally bioavailable [R].

This is why a SARM like LGD-4033 is so promising, as it is non-steroidal, extremely selective, and exhibits a high level of bioavailability [R].

Testosterone exhibits a 2:1 selectivity for muscle to prostate [R].

Testosterone exhibits a two to one selectivity of muscle tissue to prostate

In men, treatment with testosterone and other anabolic androgenic steroids (AAS) could result in prostate growth stimulation and artificially induce hypogonadism, hence why a more selective treatment that can target muscle tissue and bone specifically would be a more desirable alternative [R].

In women, treatment with testosterone or other AAS can lead to the development of male gender characteristics (virilization), hence why a more selective treatment that is capable of fulfilling the same functions of androgens would be a more desirable alternative [R].

Testosterone induces significant androgenic activity at therapeutic dosages which disqualifies it entirely as an optimal treatment for muscle and bone wasting diseases.

This is why SARMs like Ligandrol may prove to be safer, more effective alternatives [R].

The ideal anabolic agent should demonstrate anabolic selectivity in muscle and bone without suppressing luteinizing hormone (LH), not negatively interact with other steroid receptors in the body, exhibit a high level of oral bioavailability without being 17 alpha-alkylated, and avoid 5-alpha reduction to DHT and aromatization into Estrogen [R].

SARMs were first discovered in 1998, following which several different compounds were developed by a variety of pharmaceutical companies in order to find a viable compound to satisfy this obvious need in degenerative disease treatment [R].

Mechanism Of Action

LGD-4033 has a high level of bioavailability, meaning it can be dosed orally as opposed to requiring intramuscular injection, as is the case with most traditional anabolic steroids.

It also does not require 17 alpha-alkylation in order to be absorbed and utilized in the body, as opposed to 17 alpha-alkylated oral anabolic steroids that are intentionally designed to be liver toxic with a methyl or ethyl group at the C17α position so they are orally bioavailable.

SARMs, like LGD-4033, stimulate androgen receptors in a selective way, whereby they induce a significantly greater amount of anabolic activity in the body relative to androgenic activity [R].

LGD-4033 binds to the androgen receptor with an extremely high affinity (Ki of ~1 nM) and selectivity, and once it does this it exerts anabolic effects in muscle tissue and bone.

Due to the tissue-selective mechanism of action and oral route of administration, Ligandrol may be effective at producing all of the therapeutic benefits of testosterone with a vastly improved safety profile.

The negative effects that stem from traditionally used anabolic steroids converting to 5α-reduced androgens that can increase the risk of benign prostate hyperplasia, prostate carcinoma, acne breakouts, and substantially expedited male pattern baldness could potentially be averted entirely if LGD-4033 became an approved treatment alternative in a clinical setting.

LGD-4033 could potentially provide a sufficient amount of anabolic stimulation to completely mitigate muscle wasting and bone degradation, while simultaneously avoiding the occurrence of androgenic side effects in women entirely.

The lack of androgenicity is favorable for both men and women, but it proves especially useful in the context of treating women, as even low dosages of anabolic androgenic steroids would induce virilization.

Finding a balance between a therapeutic amount of anabolic activity with a near complete absence of androgenic activity is extremely difficult to integrate into an anabolic agent, but the clinical data suggests that Ligandrol may be capable of achieving just that.

After binding to the androgen receptor, LGD-4033 blatantly exhibits the ability to increase muscle mass and strength, and it is also reported to increase bone formation, bone strength and decrease bone resorption [R].

Aside from Ostarine, LGD-4033 is the closest SARM to making it through clinical trials and being approved.

LGD-4033 Clinical Trials

LGD-4033 (VK5211) Pipeline
LGD-4033 (VK5211) Pipeline

Preclinical

LGD-4033 has undergone extensive testing in a number of preclinical animal models.

Preclinical Rat Models

The data revealed a greater than 500-fold selectivity of muscle tissue to prostate in rats.

A greater than 500:1 anabolic to androgenic selectivity would make LGD-4033 the most selective SARM to date, even more so than BMS-564,929, which has a selectivity of 160:1, and may have had its overall potency in muscle tissue exaggerated in its preclinical findings [R].

In the preclinical studies castrated rats that were given LGD-4033 experienced increased muscle size, and in a rat model of osteoporosis, the rats experienced increased bone mineral density.

To exhibit tissue selectivity in rats, they were castrated and left untreated for 14 days to provide ample time for muscle and prostate atrophy.

Following which, the rats were administered varying dosages of LGD-4033 for the next 14 days.

The following graph illustrates the data derived from the preclinical studies which exhibits how much LGD-4033 stimulated muscle growth relative to prostate growth in comparison to Testosterone.

LGD-4033 Selectivity For Muscle To Prostate Compared To Testosterone
LGD-4033 Selectivity For Muscle To Prostate Compared To Testosterone

According to Viking, Testosterone shows no tissue selectivity in the data, which isn't exactly true, as it does exhibit a 2:1 selectivity up to a certain point.

Any anabolic agent will become more androgenic:anabolic the higher the dosages are pushed, as a diminishing returns effect sets in with the anabolic component.

The goal of SARMs is simply to replicate the therapeutic benefits of Testosterone though, not to create a super hormone that can dose dependently build muscle with limitless capabilities while simultaneously having 0 androgenic effects at all dosages, as that would be unreasonable and impossible to develop (for now).

LGD-4033 stacked up against Testosterone very well in the preclinical models with a greater than 500x tissue selectivity of muscle to prostate.

In the preclinical rat model of osteoporosis, ovariectomized female rats were allowed to develop osteopenia for eight weeks before once-daily oral treatment with LGD-4033 for 12 weeks.

LGD-4033 successfully increased lumbar spine bone mineral density as effectively as Estradiol and Testosterone (graph on the left), and also significantly decreased trabecular bone turnover compared to placebo (graph on the right).

LGD-4033 Rat Model Of Osteoporosis Bone Mineral Density and Bone Formation Rates

Preclinical Primate Model

In a preclinical primate model, Cynomolgus monkeys were orally administered Ligandrol once per day at dosages of 0, 0.6, 3, 15, or 75 mg/kg for 13 weeks.

Ligandrol treatment resulted in a dramatic increase in lean muscle mass compared to the placebo group.

The results showed a significant increase in body weight in both male and female monkeys during the study.

Body weight increase was measured in % gained (y-axis of the graphs).

Preclinical LGD-4033 Study On Primates - Substantial Increases In Lean Body Mass At 13 Weeks

After 13 weeks of once per day dosing, there was a significant increase in body weight for all monkeys except the untreated group.

The 75 mg/kg dosing was stopped after 48 days due to signs of toxicity.

This isn't very relevant to Viking's Phase 2 clinical trial though, as human dosages did not exceed 2 mg per day.

More than than 70% of the mass gained was retained after a four-week recovery period when the weight of the monkeys was checked again.

Body weight gain was significant after 13 weeks treatment with VK5211 in cynomalgus monkeys

The preclinical data suggests that Ligandrol is highly selective for muscle tissue, and could potentially perform with a much improved therapeutic profile in a clinical setting relative to testosterone.

Phase 1

Three Phase 1 studies on LGD-4033 were successfully accomplished.

The Phase 1 trials are the first stage of testing in human subjects designed to assess safety, side effects, best dosage, and formulation method for the drug.

The takeaway from all Phase 1 human trials was that LGD-4033 exhibits a very encouraging safety profile and tolerability at dosages that provide significant improvements in lean muscle mass, and positive trends in strength and performance measurements.

Single Ascending Dose Study

The first Phase 1 trial involving LGD-4033 was a randomized, double blind, placebo controlled trial conducted in 2009 on 48 healthy male volunteers.

The volunteers were divided into six cohorts and received an escalating daily dosage of LGD-4033 ranging from 0.1 mg per day to 22 mg per day.

All doses of LGD-4033 tested in humans (even the 22 mg per day dosage) were shown to be safe and well-tolerated, with predictable pharmacokinetics.

The pharmacodynamics results showed dose-dependent reductions in total serum testosterone levels, sex-hormone binding protein (SHBG), and fasting serum HDL, which is consistent with the mechanism of action of SARMs (and all anabolic agents).

21 Day Multiple Ascending Dose Study In Healthy Young Men

The second Phase 1 trial involving LGD-4033 was a placebo-controlled study conducted on 76 healthy men (21–50 years).

They  were randomized to placebo or 0.1, 0.3, or 1.0 mg LGD-4033 daily for 21 days.

Blood counts, chemistries, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and for 5 weeks after intervention.

LGD-4033 was shown to be safe and well-tolerated [R].

There was a dose-dependent suppression of total testosterone, SHBG, HDL cholesterol and triglyceride levels.

FSH and free testosterone only showed significant suppression at the 1 mg per day dosage.

Lean muscle mass increased significantly in a dose dependent manner, with minimal changes in fat mass [R].

Hormone and lipid profiles all returned to baseline after treatment discontinuation.

There were no drug related serious adverse events, no liver toxicity, no negative effect on electrocardiogram results, and no adverse effects on Prostate-Specific Antigen (PSA) levels [R].

There was a dose proportional increase in drug concentration on days 1 and 21, suggesting that accumulation occurs upon multiple dosing, which is very important to note.

If someone took the same dose every 24 hours, LGD-4033 would eventually accumulate to extremely high levels in the blood.

It would be wiser to assume the half life is closer to 36 hours based on the clinical data in this study.

Change In Lean Body Mass - LGD-4033 Phase 1 Trial
Change In Lean Body Mass – LGD-4033 Phase 1 Trial

LGD-4033 increased lean body mass on average 1.21 kg (2.67 pounds) at the 1 mg dosage [R].

The increase in lean body mass was dose-dependent, and can be assumed will increase more as the dosage increases.

The capability of LGD-4033 to increase lean muscle mass in such a short time span without negatively affecting PSA levels bolds well for its efficacy and safety profile moving forward.

7 Day Study In Elderly Men And Women

The third Phase 1 trial involving LGD-4033 was conducted to evaluate the safety, tolerability and pharmacokinetics properties of LGD-4033 in elderly subjects.

This study is assumed to be the most representative of the hip fracture population, which is the main clinical application Viking seeks approval for with LGD-4033.

The end goal is to receive approval to treat patients who have suffered a hip fracture by slowing or prevent the loss of their lean body mass or bone mineral density.

LGD-4033 had predictable pharmacokinetics (similar to those reported in younger male subjects) and was shown to be safe and well-tolerated at all doses evaluated with no serious adverse events observed.

Phase 2

In Phase 2, the scope of treatment applications for LGD-4033 narrows as there needs to be a specific condition that the SARM is meant to treat in order to receive approval.

In this trial, the efficacy and safety profile of LGD-4033 in the maintenance or improvement of lean body mass, bone mineral density, and function in patients recovering from non-elective hip fracture surgery is assessed.

Negative Changes In Body Composition Following A Hip Fracture

Hip fracture is associated with a number of morbidities, most of which are a consequence of lean muscle loss and bone degradation following hip fracture surgery.

Within the first year after a hip fracture, body fat levels increase by up to 7% on average, while lean muscle mass decreases by up to 11% [R, R].

Typically, healthy older females without hip fractures would only lose approximately 1% of their lean tissue per year and gain 1.7% body fat [R].

Bone mineral density also severely declines in hip fracture patients.

The negative changes in body composition following a hip fracture are represented in the following graphs [R].

Body mass outcomes after hip fracture.
Lean Muscle Loss After Hip Fracture
Bone mineral density outcomes after hip fracture.
Bone Mineral Density Loss After Hip Fracture

The ability to slow or prevent the loss of lean body mass or bone mineral density would likely have a profound impact on patient recovery following hip fracture.

LGD-4033 Phase 2 Trial Results

The first LGD-4033 phase 2 trial started October 30th in 2015 and completed in March, 2018 [R].

The clinical trial was 12 weeks long and involved 108 patients (83 women and 25 men) who were at least 65 years old and had suffered a hip fracture within the past three to seven weeks.

Subjects were administered placebo, or 0.5 mg, 1.0 mg, or 2.0 mg of LGD-4033 once-daily for 12 weeks.

The primary goal of the trial was to assess changes in lean body mass, with secondary and exploratory endpoints including assessments of patient quality of life, functional status, change in appendicular lean mass, total lean body mass, bone mineral density and activities of daily living.

LGD-4033 Phase 2 Trial Results - Changes In Lean Body Mass

LGD-4033 produced significant increases in lean body mass and appendicular lean mass following 12 weeks of daily dosing in all subjects.

A consistent dose response was observed across all primary and secondary efficacy measures.

LGD-4033 exhibited encouraging safety and tolerability, and there were no drug-related serious adverse events in the study.

Is LGD-4033 As Strong As Steroids?

It is typically not a relevant comparison to make between Ligandrol and most steroids because the dosages that are compared are so much different.

For example, 10 mg of Equipoise (Boldenone) per day would not equate to nearly as much muscle growth as 10 mg of LGD-4033 per day.

I believe LGD-4033 is absolutely as potent of a muscle builder as moderate dosages of Primobolan, Turinabol, Boldenone, Anavar, and several other anabolic steroids.

I have yet to see data on a steroid exhibiting a lean muscle gain of 2.67 pounds using only 1 mg per day.

At therapeutic dosages, milligram for milligram LGD-4033 will outperform Anavar, Turinabol, Primobolan, Equipoise, and many other traditional anabolic steroids, with a favorable selectivity for anabolic:androgenic activity.

LGD-4033 is significantly more potent than many very well known testosterone analogs [R].

LGD-4033 Vs Nandrolone

In an assessment of change in lean body mass at 6 months in hip fracture patients, LGD-4033 significantly outperformed Nandrolone in muscle gain.

Nandrolone is one of the few anabolic steroids that was approved for clinical use in humans, and remains a very popular steroid for performance enhancement to this day.

More commonly known as “Deca” (Nandrolone with the Decanoate ester) or “NPP” (Nandrolone with the phenylpropionate ester). 

LGD-4033 Vs Nandrolone LBM Gain
LGD-4033 Vs Nandrolone

LGD-4033 Vs Anavar

10 mg of LGD-4033 vastly outperforms Anavar in all efficacy measures.

Lean muscle gains and strength gains are significantly more pronounced with LGD-4033, and it is just as well tolerated by both men and women.

I personally know over 10 women who've tried both on separate occasions for performance enhancing purposes.

Every single one reported far better results from LGD-4033.

How LGD-4033 Compares To Other SARMs

LGD-4033 has a competitive effect on total lean body mass relative to other clinical-stage SARMs, and is more potent on muscle compared with myostatin-targeting approaches.

LGD-4033 Vs Ostarine

While Ostarine also has an encouraging efficacy profile and is clearly very selective for muscle tissue relative to prostate (and other androgen affected tissues), in comparison to LGD-4033 it is weaker in almost all facets.

Milligram:Milligram Ligandrol (VK5211) outperforms Ostarine (Enobosarm) with greater increases in lean muscle mass and strength.

However, Ostarine is less suppressive than LGD-4033, which can be important for recovering baseline hormone levels as quickly as possible after discontinuation.

LGD-4033 Vs RAD140 (Testolone)

RAD140 is commonly compared to LGD-4033 as a “bulking” compound.

RAD140 is reported to be a dryer compound, with the potential to increase strength even more so than LGD-4033.

Some individuals seem to respond better to one or the other, with impressive gains in strength being consistent with either of their use.

When it comes to hypertrophy, LGD-4033 seems to outperform RAD140 in most instances (not always the case), making it the candidate of choice for most for sheer lean muscle size gains.

It should be noted that RAD140 is still in the preclinical stage, meaning it had no current human trials to use as referential data, and those conclusions are drawn purely off of anecdotal logs.

Granted, there are thousands of anecdotal logs (on humans) now to reference, which are quite insightful, but they are certainly no replacement for approved clinical trials.

LGD-4033 Vs S23

S23 is a SARM in the preclinical stage being developed by GTx, Inc as a potential male hormonal contraceptive (the same company that created Ostarine).

It binds to the androgen receptor harder than its predecessors (like Andarine) and has an extremely potent effect in muscle, with a high level of selectivity.

Comparing LGD to S23 head to head there are many who would argue that S23 is the strongest SARM in development right now, and they could be right, however, its still in the preclinical stages, and it is extremely suppressive.

This is why it is being developed as a potential male contraceptive right now, it is far more suppressive than LGD-4033.

In the preclinical rat model, S23 suppressed LH levels by more than 50% after only 14 days with doses as low as 0.1 mg per day [R].

There are also reports of aggression with S23, as well as some strange side effects like dehydration and increased body temperature.

While some hardcore recreational biohackers may opt to experiment with S23 because of all of the positive anecdotal experiences that can be found online, LGD-4033 is the more promising SARM at the moment overall.

LGD-4033 Vs LGD-3303

LGD-3303 was hyped up as a superior alternative to LGD-4033, and in its preclinical model appeared to have some encouraging results.

While it appears to still be in the preclinical stage, it is unclear if any developments have taken place since that first study, as it was completed over a decade ago in 2008.

Anecdotally, LGD-4033 appears to be the candidate of choice among recreational users, with it consistently outperforming LGD-3303 mg:mg in lean muscle gains and strength gains.

Some users swear by the efficacy of LGD-3303, so it shouldn't be written off entirely, but there is simply an overwhelming amount more evidence to support LGD-4033 as the superior SARM of the two.

LGD-4033 Results (Anecdotal/Recreational Use)

As shown in the clinical trials, LGD-4033 can increase lean muscle mass by 2.67 pounds within three weeks (on average) in young men at a dosage of 1 mg per day [R].

Predictably, LGD-4033 became a popular addition to athlete's regimens who were seeking performance enhancement.

I have personally seen several very impressive transformations accomplished using only SARMs.

Muscle Gains

Gains upwards of 5-10 pounds of lean muscle mass are commonly reported among recreational users within a 4-8 week cycle.

LGD-4033 is often referred to as the best mass building SARM, as it seems to exhibit greater muscle building potential than all other first-generation SARMs.

Typically, it is incorporated into bulking phases where LGD-4033 is used to enhance strength and hypertrophy in conjunction with a calorie surplus.

Users report some water retention with Ligandrol usage, however, I believe that this has more to do with body composition, daily water/potassium/sodium intake, caloric intake, cardio regimen (or lack thereof), and overall diet choices.

However, predicting how much muscle an individual will gain from LGD-4033, or any anabolic agent for that matter, can vary wildly depending on a variety of factors.

Strength Gains

Substantial increases in strength are commonplace among recreational users as well.

A handful of users have reported increases in strength of their flat barbell bench press, squat, and/or deadlift by as much as 100 pounds in a focused bulking phase.

If a diet comprised of enough macronutrients, micronutrients and overall calories is adhered to for the duration of a LGD-4033 cycle, anecdotal reports suggest that gains of muscle upwards of 10 pounds and strength gains of 50-100 pounds on compound exercises are realistic.

My LGD-4033 Review

I've used LGD-4033 a handful of times, and my experience was fairly consistent with other anecdotal reports, but to a much lesser extreme.

By the time I tried it, I already had several cycles of anabolic steroids under my belt, so I didn't expect it to really blow me away.

My experience is less useful to reference as my body is already above and beyond my genetic limit via years of previous anabolics usage, however, I do believe that of all the SARMs, I feel that LGD-4033 had the greatest overall effect with the best side effect profile for me personally.

I also didn't lose any hair from it, which to me is the number one draw of an anabolic agent.

Once more data comes out on Ligandrol, I may start titrating my TRT down a bit more and start incorporating it in some capacity into a long-term regimen, as opposed to the way I've used it to date which is in intermittent “blast” phases.

The only other compound I believe is formidable to LGD-4033 in regards to overall size and strength gains is S23, which is still in the preclinical stages and hasn't been trialed in humans yet.

LGD-4033 Dosage

Milligram : Milligram, LGD-4033 induces substantially more anabolic activity than any other viable SARM alternative, and even outperforms most anabolic steroids.

The first Phase 1 study conducted on LGD-4033 established safety and tolerability of LGD-4033 up to dosages of 22 mg per day in humans.

It is very unlikely that 22 mg per day will be necessary to replicate the anabolic properties of Testosterone to prevent the loss of lean muscle or bone mineral density in hip fracture patients, however, it is useful to know that it has established a fairly encouraging safety profile even at dosages as high as 22 mg.

LGD-4033 produced dose-dependent effects on primary and all secondary measures of lean body mass, with significant increases in lean body mass and appendicular lean mass following 12 weeks of daily dosing.

The highest dosage utilized in Phase 2 clinical trials was 2 mg per day for therapeutic purposes [R].

In a recreational capacity, it is quite common for men seeking performance enhancement to report using 10 – 20 mg of LGD-4033 per day, with women using 5 – 10 mg per day.

These dosages were determined by recreational users based upon anecdotal logs and personal experimentation, and are not concrete guidelines that dictate correct or incorrect use.

Side Effects

While LGD-4033 was generally regarded as safe in human trials using dosages as high as 22 mg per day, that doesn't mean it had no negative side effects.

These were some of the negative side effects reported in the clinical data, as well as anecdotally among recreational users.

Decreased Good Cholesterol (HDL)

The clinical data shows dose-dependent suppression of HDL cholesterol and triglyceride levels with LGD-4033 usage [R].

A negative effect on HDL levels is consistently noted as a common side effect of all traditional anabolic steroids, and other SARMs.

Despite SARMs ability to be selective about how they exert anabolic activity in the body, they evidently do not differ much from anabolic steroids in regards to their effects on lipid profiles.

Testosterone Suppression

SARMs have shown to suppress luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the hypothalamus-pituitary-testis axis, thus decreasing testosterone in a dose-dependent manner [R].

Ligandrol suppressed Sex Hormone-Binding Globulin (SHBG) and total testosterone levels in clinical trials in a dose-dependent manner.

Serum free testosterone and FSH levels were only suppressed in the subjects treated with 1 mg of Ligandrol [R].

There was no LH suppression in subjects treated with Ligandrol during the 21 day clinical trial conducted on healthy young men.

However, the treated groups were only administered either 0.1 mg, 0.3 mg, or 1.0 mg for three weeks, which are relatively low dosages and is also a short time frame.

Based on the overwhelming supporting data on anabolic agents collected over the past 50 years, I believe it's safe to say that LGD-4033 will show blatant reductions in all of these hormone markers in a dose dependent manner, and the dosages in the studies just weren't high enough to consistently yield this data.

At higher dosages (above 1 mg), I am sure serum free testosterone levels would drop considerably as the dose was titrated up, and other markers would decrease in parallel.

Elevated Estrogen Or Decreased Estrogen

LGD-4033 does not aromatize into Estrogen, however, by suppressing natural Testosterone levels it can create an unfavorable balance between Testosterone and Estrogen in the body.

By occupying the androgen receptor with such a high affinity, LGD-4033 can divert a significant amount of Testosterone to aromatize into Estrogen that wouldn't have otherwise.

The consequence of this is a systemic elevation of Estrogen levels in the body, which is commonly misinterpreted as prohormone laced SARMs.

Common symptoms of high estrogen include:

  • Acne, oily skin
  • Erectile dysfunction
  • Low libido
  • Lethargy
  • Gynecomastia (man boobs)
  • Irritability
  • Depression
  • Water retention
  • High blood pressure
  • Enlarged prostate
  • Shrunken testicles
  • Sugar cravings

While LGD-4033 can cause Estrogen levels to rise via the increased aromatization of circulating Testosterone, long-term use, or high dosages of LGD-4033 can cause an opposite effect, where the body has such a low level of circulating Testosterone via endocrine suppression that the body no longer has enough aromatization occurring to satisfy Estrogen fulfilled physiological functions.

Low Estrogen levels can lead to a variety of health problems.

Common symptoms of low estrogen include:

  • Dull weak orgasms
  • Dry skin and lips
  • Dehydration
  • Erectile dysfunction
  • Low libido
  • Irritability
  • Mood swings
  • Loss of appetite
  • Fatigue
  • Lethargy
  • Decreased bone mass and strength

Applications In Alternative Hormone Replacement Therapy In Men

As Ligandrol does not aromatize into Estrogen, it would automatically be disqualified as a viable standalone hormone replacement therapy treatment for men.

Estrogen serves several important functions in the male body, and those functions rely on a sufficient amount of Estrogen being produced via the aromatization of endogenous Estrogen.

Low Estrogen side effects can be just as deleterious as high Estrogen side effects.

In a hypothetical scenario where Ligandrol would be considered as a potential long-term HRT treatment, it would very likely need to be used in conjunction with exogenous Estrogen to maintain healthy blood serum concentrations that would have otherwise been achieved via adequate Testosterone to Estrogen aromatization.

Androgenic Activity

LGD-4033 exhibits a dose dependent increase in androgen activity in the body.

While it is extremely selective for muscle tissue and bone relative to androgen affected tissues, all SARMs (LGD-4033 included) result in systemic increases in androgen activity, therefore there will still be some potential for androgenic side effects.

The extent to which this will occur is just far less.

As LGD-4033 has an anabolic:androgenic ratio of greater than 500:1, the therapeutic dose necessary to yield the desired level of muscle and bone mineral density retention in hip fracture patients would very likely not be high enough where any notable androgenic activity could occur.

In a performance enhancement context, very high dosages would likely result in some notable androgenic side effects in the body.

Hair Loss

All androgens can cause hair follicle miniaturization, the extent to which they do this is dependent on their individual selectivity, binding affinity, and the dosage used.

In general, therapeutic dosages of LGD-4033 should not cause any notable androgenic alopecia.

However, this does not exclude temporary shedding (acute telogen effluvium) which can be triggered by a hormonal fluctuation.

Any substantial shift in a man's hormone profile can cause hair roots to be pushed prematurely into the resting state.

Any hormonal fluctuation, stressor, autoimmune response, deficiency or chemical imbalance can potentially cause a temporary shed.

This is not to be confused with androgenic alopecia, which is permanent hair loss caused by androgen induced follicular miniaturization.

Liver Toxicity

LGD-4033 did not result in any significant changes in AST or ALT levels in human trials [R].

However, it should be noted that in a relevant clinical trial conducted on Ostarine (a SARM with an identical mechanism of action), short-lived increases in ALT to above the upper limit of normal were observed in eight subjects [R].

Taking this into consideration, it's entirely possible that LGD-4033 could potentially also exhibit some degree of liver toxicity at dosages higher than the 1 mg trialed where they assessed those health markers.

At therapeutic dosages, there appears to be a strong safety profile and the data suggests a complete absence of liver toxicity.

Lack Of Aromatization And 5-Alpha Reduction

SARMs are resistant to metabolism by 5α-reductase and aromatase.

The most potent androgen in the prostate is dihydrotestosterone (DHT), which is formed by 5α-reduction of testosterone.

5α-reductase is expressed in high levels in the prostate, and very low levels in muscle tissue.

A study that assessed how much of a role endogenous DHT plays when it comes to building muscle discovered that it literally does nothing for gains in muscle mass, and that the conversion of testosterone to DHT is not essential for mediating its anabolic effects on muscle [R].

This is contrary to what many people assumed, as DHT on is such a potent androgen.

However, the fact that DHT is expressed in high levels in the prostate, but in low levels in muscle and bone, coupled with the data from that study, exhibits the true significance of DHT in prostate and testosterone in muscle and bone.

Ligandrol does not undergo 5α-reduction, which is speculated to contribute to its sparing effect on the prostate and other androgen affected tissues.

This is not the case though, as there are several androgens that do not undergo conversion to a more androgenic compound when undergo 5α-reduction.

One of the most notable being MENT (Trestolone).

Some androgens exhibit higher levels of androgenicity prior to 5α-reduction, and actually cause more androgenic side effects in the body when they are inhibited by 5α-reductase inhibitors.

A prime example of this is the anabolic androgenic steroid Nandrolone.

Effect of a 5α-Reductase inhibitor on the androgenic activity of Testosterone, Nandrolone and MENT (Trestolone) in castrated rats.

Ligandrol is inherently selective for the androgen receptor, and its selectivity for muscle tissue and bone relative to prostate is not a result of its inability to be altered by 5α-reductase.

Half-Life

LGD-4033 displayed a prolonged elimination half-life (24–36 hours), linear pharmacokinetics, and predictable accumulation with multiple dosing [R].

Dose proportional increase in systemic exposure on days 1 and 21.

There was a dose-proportional increase in LGD-4033 concentrations on days 1 and 21 because of its long half-life.

Despite being reported to have a half-life of 24-36 hours, it would be wise for users to err on the side of caution and take into consideration that serum concentrations were nearly threefold higher on day 21 than on day 1 in the second Phase 1 trial.

This means that once daily dosing will result in concentration build up of the compound over time, as 24 hours is not enough clearance time to assume that once daily dosing will equate to stable blood serum concentration levels [R].

LGD-4033 Bulking Cycle

In a calorie surplus LGD-4033 will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

MK-677 (Ibutamoren) and SARMs like RAD140 or S4 are commonly stacked alongside LGD-4033 in more involving performance enhancement bulking protocols.

LGD-4033 Cutting Cycle

In a calorie deficit LGD-4033 will retain much more lean muscle mass than would otherwise be possible naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user's individual timeline constraints for reaching a goal body fat percentage).

Cardarine (GW501516) and SARMs like RAD140 or S4 are commonly stacked alongside LGD-4033 in more involving performance enhancement cutting protocols.

PCT (Post Cycle Therapy)

LGD-4033 will suppress natural Testosterone levels in a dose-dependent manner.

I believe it is essential to complete a PCT phase (post-cycle therapy) after a LGD-4033 cycle.

Due to the half-life of LGD-4033, PCT should be started the day after the last dosage was taken.

Forgoing PCT will greatly increase the risk of muscle loss, fat gain, among all of the other standard side effects associated with Testosterone suppression.

How much time off you should take after your PCT should be dictated by a variety of individual specific factors and blood work.

I would not advise following the standard “time on = time off” equation.

Buy LGD-4033 (Ligandrol)

Most LGD-4033 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I highly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure LGD-4033:

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

172 thoughts on “LGD-4033 (Ligandrol) – Results, Clinical Trials & Reviews”

  1. Great article. Never heard of this sarm before, and will definitely be getting this.

    What if any… would be a good fat loss sarm for women?

    1. Ostarine, Cardarine and S4 I feel like would be the greatest combination of SARMs for a woman looking for a total body transformation with a substantial amount of fat loss.

      If you are just looking for a pure fat burner by itself though the CODE RED Fat Burner product I have used works very well and I wouldn’t hesitate to recommend that as well (it isn’t a SARM)

    2. Can my labrats stack Arachidonic Acid code red fat burners and lgd 4033? Or would it better better if I stacked mk 2866 , code red fat burners and Arachidonic Acid I appreciate all advise thanks

      1. Makes no difference, the only difference you’ve proposed is your choice of anabolic. If you’re cutting (which I’ll assume you are based on the use of a fat burner) either or will serve the purpose they are meant for in a cut (preserving your muscle mass).

  2. Was waiting for this one, really like these articles you go into awesome detail on everything. And those cycle suggestions are also awesome, keep up the good work.

    1. For several years if you store it in proper conditions (room temperature, in a cool dry place, out of the light)

    1. In almost all cases, no. If you research it responsibly you shouldn’t encounter the need for something like Nolva.

  3. I have a question, when you gain lean muscle mass from LGD, after you stop taking it, will you lose the muscle like from steroids or not ? Thx

      1. Thx, it should work, nice look btw, have you ever used anything else, or the majority of your gains are from Sarms ?

        1. Yes I have experience with AAS as well. My gains are majorly built from enormous amounts of food and training until I puke though 😛

          I definitely paid my dues to get the foundation I did.

  4. Hey Derek Love the site and all the work you do to help us. I was wondering if I should run red pct during my current cycle with lgd or just post?

  5. Why would RED PCT be the choice for PCT off LGD? It is an AI which decreases estrogen. SARMs as far as I know does not increase estrogen but only have mild suppression effects to decrease test. Also Red-PCT has liver support in it, no need to go on that from SARMs.
    Would not Nolvadex be better? Albeit it won’t require a longer PCT like steroids but I am confused on why RED-PCT over SERMs (Clomid or nolva). Thanks

    1. SARMs can cause mild estrogen elevation, and RED PCT isn’t a harsh enough AI to crash them below the sweet spot, it brings them back into the 20-30 pg/mL range quite nicely. Also, it drastically increases natural testosterone levels in a short period of time.

      Basically, RED PCT is good for light/moderate SARM cycles, but if you’re doing a heavy dosed long one with several compounds then a standard Nolva/Clomid PCT will become more necessary.

      Checkout this article for some blood work exhibiting the results of RED PCT: How to ACTUALLY Increase Your Free Testosterone Levels with Red-PCT (with Blood Work PROOF)

  6. Hi I want to start taking LGD 4033 is it vigitarian I mean no gilatin on it or can you advice me for something without gilatine thank you

  7. So i got the stack that has ostamuscle and bunch of fat loss stuff it was $199 from EA (used your code too) but was wondering if it would be too much if i threw in the lgd and the aracidonic acid too? Im pretty heavy set so i definitely want to lose weight but still want to get mad gains too. Should i finish the stack first or just do it all?

    1. You’re cutting and trying to lose fat, you will not be making “mad gains” if you are heavy set and want to get ripped.

      Your diet will dictate your results, not how much aracidonic acid and SARMs you are using. The purpose of SARMs in a cut is to preserve all your lean muscle tissue, there will not be any colossal size or strength gains being made while in a sufficient caloric deficit to lose a substantial amount of fat.

      Pick one goal and stick to it.

      Save the LGD for bulking. If you were deadset on adding another SARM alongside Osta I would use S4 before LGD if I was cutting.

      Osta + S4 + Cardarine is a fantastic fat loss, muscle retaining, endurance skyrocketing, muscle hardening stack. With the fat burners and a good diet and cardio + training regimen, getting shredded shouldn’t be all too difficult. Osta + the fat burners being the most pivotal of the stack, with S4 coming in closely afterwards (great for muscle hardening and strength retention), and then Cardarine I feel like is the least important if budget is a concern, but it greatly improves endurance and aids fat loss a bit, which is very helpful when doing cardio on a regular basis.

      LGD I prefer in the off-season (bulking).

  8. Hi, I just finished up a cylcle of a Prohormone, could i run this with my pct at the same time? So am i able to take my pct & lgd run those for a month together then run another month on LGD stand alone & be alright with gaining my natural test back? I would run another mini pct after thw 8 weeks of course but I dont want to be shut down for 8 weeks. Please help

    1. LGD is suppressive, so no you can’t run this during PCT because it will prevent your endocrine system from recovering (the purpose of PCT).

  9. Hi Derek,

    First I just want to say thank you for providing great information on LGD.

    I’ll be taking LGD as a standalone product and I just want to confirm the following before starting:

    1.) Start with a low dosage of 5mg… working up to the sweet spot of 10mg… doing no more than 20mg

    2.) Once cycle is complete follow up with RED PCT.

    Thanks!

    1. Yes. 10mg as a starting point for research would be fine too, that approach is just really for those who want to be very conservative starting at 5mg. No need to exceed 20mg in my opinion though yes.

      RED-PCT or Arimi-RX PCT will suffice (exact same product essentially). Use discount code DC15 if you order the Arimi-RX to save some money.

  10. I am 23years Old, 6 feet and 68KG. I wasn’t training from 6months but now back to train and its been 40days. I am thinking of taking SARM once I completed 60-75days of training.

    I want to gain muscle mass that’s my main objective and I don’t want to take much risks.

    What would be safest way?
    Only Ostarine 4weeks then 2 week gap then 4 week again.
    Or
    4week LGD or YK11 ? Then 2 weeks PCT
    Then 4 week Ostarine.
    Or

    1. It sounds like you need to do more research. Read my articles and checkout some more info on the internet before you start these compounds. It isn’t something you just jump into without knowing what you’re getting yourself into.

  11. I have been reading about it from a week now and all of them seems to be doing the same things. While I found out Ostarine is one of the best on the other hand alot of people said YK11 or LGD is best for bulking at the first place.
    I never found anything or anyone who has explained all these three against each other at the same place though.

    I will surely read more of your articles and write back.

  12. Hey Derek,

    Great write up here, thanks for all the solid info. I have a question…

    I’m 4 weeks into a 10mg/day LGD cycle. I think I’m experiencing some “early” suppression – I’m fatigued, a little foggy mentally, and haven’t been getting the usual “morning wood.”

    I don’t want to jump off too soon, I would like to finish the cycle (I was going to run for 6-8 weeks). So, in your opinion, would taking one cap of Arimi-RX PCT a day right now help me out? Is there anything else you would do or recommend?

    Thanks man.

  13. Wish you would promote someone other than Enhanced Athlete. Not only have they raised their prices but they rarely have products in stock. And, what they do have in stock takes up to a week before they shop it out … horrible service.

    Will you consider doing a video/article on stimulating appetite for mass gain? Mk-677 is amazing for stimulating appetite but it only lasts a few weeks. Is there a way to consistently so this?

    1. I do. I’ve been telling guys for months that if EA is out of stock of something or you live in Canada then you should go with Neobolics.com They charge in Canadian currency and their quality is great for all of their products. It’s my second go to up here in Canada when EA is out of stock of items.

      Use discount code DC10 to save 10% off your entire order at Neobolics.com.

      Yes GHRP-6 is a better option than MK-677 at consistently being able to stimulate appetite. That and cardio, and portioning your meals properly. There are some other strategies I’ll try and find the time to make a video/article on it in the future.

  14. Amazing read ! For the cycle could you stack the lgd with the ostamuscle ? Or would that just not work well with one another? As for the times to take the lgd, gh, and pct, what times of the day would you suggest for each pill? I understand you already explained to take it during the am and pm, but would i take the lgd before a workout and the gh and pct after the workout before bed ? And id have to take the pill at around the same time every day or it dosent matter what time i take the pill the next day as long as i take the one dose a day?

    1. I don’t like stacking LGD with Osta as I find they perform very similarly on the androgen receptor. I’d prefer using a GH secretagogue like MK-677 or other SARMs like S4 or RAD-140 depending on goals.

      Timing is ultimately irrelevant because the half-life is 24 hours, however, for MK-677 taking it pre-bed vs. in the morning can affect lethargy levels differently for different people as the initial GH pulses may make you drowsy, hence why I prefer it pre-bed becuase then it doesn’t affect my work day significantly.

      Ideally you’d want to keep dosing at the same time each day because the half-life is 24 hours, but it won’t make a substantial difference if you are off by a few hours at all.

  15. I like the simplicity of your cycle and it helps me a lot.

    My quick question is since EA LGD bottles has enough to run for 30 days and if I buy 2 bottles 60 days.Can the same protocol apply if I were to run LGD for 60 days.

    Day 1-60 : LGD-4033 10mg per day dosed once per day in the AM

    Week 1-60: 1 Pill Arimi-RX PCT dosed once per day in the AM

    (Mini-PCT) for 3 weeks : 3 Pills Arimi-RX PCT dosed once per day in the AM

    Keep up the good work!!!

  16. Hey Derek just had a couple quick questions.
    If I wanted to only do a 4 week cycle…how long would i pct after for?
    And in your opinion what is the shortest yet still affective length cycle?

    I had been training hard natty for about 6 years and I just finished a 4 week osta cycle and put on 18lbs. Will lgd be similar in effect and feeling just stronger?
    Thanks brah

    Also you should do a video on top 10 hair products in your opinion…you must use something good to tame that beast of yours..
    Peace!

    1. I wouldn’t even bother with a 4 week cycle, but if you do it anyways, your PCT should still be the same as it would if it was a longer cycle. Assume you are suppressed no matter what, as you very well could be.

      LGD-4033 in general will put on more size and strength than Ostarine yes.

  17. The Armi-RX is just a pure androsta pill, so I am curious why you say it is “also” a good AI. On that note, I like that its in pill, not capsule form. Do you think that pill form says something about quality? I have this notion that capsules get hand jammed with variant amounts of powders, while pills are probably made with more exact manufacturing detail. Am I right? I wish more PED were available as pills.

    1. It is a good AI because it is a good Aromatase Inhibitor… I’m not sure how else to explain it.

      No, pill vs. caps make no difference. You are ingesting raw powder. It doesn’t matter if it’s pressed into a pill or in a capsule, it does the same thing.

      1. You said, “Arimi-RX PCT isn’t only a great PCT supplement, it is also a potent aromatase inhibitor, …” Since Arim-RX is androsta, and androsta is an AI, is just seems redundant to say that it is “also a potent aromatase inhibitor.” It would be like saying, “Not only is LGD a great bulking agent, it is also a potent SARM.”

        I have seen some documentaries on companies that bottle their own capsules, at home. They have a couple bags of ingredients and some measuring spoons. They scoop the powder from the bag and into the cap and then join the cap. It looks very amateurish at best. Being the PED market is so blackmarket, I assume that this is how many or most caps are being produced. They can bypass the cost of manufacturing by ordering the ingredients from China and bottling it in the garage. When its in pill form, I at least know it wasn’t likely made in the garage with likely hugely inaccurate dosages.

  18. Hi derek-
    Just wondering how arimi rx helps with suppression or aids in avoiding supression? I was under the impression that is was just an A.I.
    Is it able to boost and recover test aswell as control estrogen levels? If so, how does it raises test levels?

    Thanks for all your great info!

    1. High estrogen leads to symptoms of suppression, as does low testosterone. By inhibiting the aromatase process, thereby preventing the conversion of testosterone into estrogen while simultaneously reducing the total amount of estrogen in the body, Arimistane can actively reduce the total amount of estrogen in our body. While reducing and inhibiting estrogen is this AI’s primary function, Arimistane also actively stimulates Luteinizing Hormone (LH) and overall testosterone production. Through this stimulation, total testosterone output can be increased.

      1. I see, that makes sense. But I thought lgd doesn’t aromatise into estrogen? Like deca or dbol etc..
        So is it only the increased test from the ldg that can aromatise and therefore the A.I stops this increased test from converting?
        Sorry if I don’t make any sense I’m just trying to get the purpose of the product straight.

        Would another product designed specifically to boost test be needed in pct aswell? Or is the arim rx sufficient to inhibit estrogen aswell as recover your suppressed test?

        Thanks for your help, really appreciate it.

        Jared

        1. LGD doesn’t aromatize into estrogen. It suppresses testosterone, which can make the ratio of estrogen to testosterone unfavourable.

  19. Hey about to use ur promo code but would u change anything about this cycle trying to get strong as possible and bulk prolly 8000 cal aday morning fasted cardio starting in may please and thanks!!

    Week1-lgd 5mg each day
    Week2- lgd 5mg
    Wk3- lgd 10mg
    Wk4- lgd 10 mg
    Wk 5-lgd 10 mg
    Wk 6- lgd 5mg
    Wk7- osta 20 mg
    Wk8-osta 30mg
    Wk9- osta 30mg w/ otc pct (got some) clomid 25-50mg
    Wk10- osta 20mg w/otc pct clomid 25mg
    Wk11- otc pct clomid 25mg
    Wk12- clomid 25mg

  20. Have you had any experience with Leviathan Research Arsenal, there have been a few video reviews on youtube and there pricing to dosage is very affordable?

    I have a question In regards to Bulking, this will be my first time taking SARMS, I was wanting to know if you think I should do a stack or single SARM only for the first time, I really like what is being said about LGD, I wanted to know your take on what main compounds to use for suppression during the cycle (ie. Tamoxifen Citrate/Clomifen) should these be taken during a stack to fight suppression or used for a PCT? I was under the impression that if your testosterone is being suppressed its due to the body recognizing it Is in abundance and no longer needs to produce. Is this not the case?

    I was thinking of running a bulk cycle of LGD, RAD-140, and MK677 together for 8weeks, then go to a ReCOMP of OSTA, S4, Cardarine and MK677 for another 8weeks then PCT of Tamoxifen Citrate/Clomifen for 4weeks.

    do you recommend running the PCT compounds during the cycle?
    do you think I should take time off between bulk and recomp?

    Also I am in the Military and want to make sure that none of these compounds will show on a standard urinalysis test.

    I’d like to close this by saying I really enjoy your articles and youtube videos, I feel like you give good unbiased information and that’s very helpful to all your subscribers. I really appreciate your help with my questions.

      1. ok, thanks for the quick reply, what do you think about the recomp right after the first 8weeks without a break in between?

        1. I don’t know why you would do 8 weeks of bulking and then 8 weeks of “recomp” when you could just do 12-16 weeks of bulking and not let yourself get as fat during the first 8 weeks.

          Recomp’s are the biggest waste of time in my opinion. Pick a goal and stick to it. If you want to gain muscle, dedicate your time whole heartedly to gaining muscle, if you are trying to lose fat, then dedicate your time to losing fat and holding onto your muscle.

          A recomp will just be a piss poor version of both of those scenarios, and you will gain a subpar amount of muscle, and lose a subpar amount of fat.

          1. ok, I can totally see where your coming from with that, as far as fighting suppression during the cycle what is a good product? or do you think I would need one with your recommendations of MK with LGD?

            Really appreciate all the help.

          2. You only “need one” if you experience symptoms of suppression, and you care.

            A low dose of Arimistane is typically sufficient to offset this. Use discount code DC15 to save 15% on it (or anything else you order).

  21. ok thanks again, I just reference what you said in your bulk video for newbies with the MK and LGD. My last question is what is in Arimistane, compound wise that fights suppression or helps maintain natural test?

    1. High estrogen leads to symptoms of suppression, as does low testosterone. By inhibiting the aromatase process, thereby preventing the conversion of testosterone into estrogen while simultaneously reducing the total amount of estrogen in the body, Arimistane can actively reduce the total amount of estrogen in our body. While reducing and inhibiting estrogen is this AI’s primary function, Arimistane also actively stimulates Luteinizing Hormone (LH) and overall testosterone production. Through this stimulation, total testosterone output can be increased.

  22. so is there a real difference in Clomid and Arimistane? I only ask because I already have Clomid and was wondering if I used it in place of Arimistane will it have the same effect?

    1. Yes there is a huge difference. Clomid is a Selective Estrogen Receptor Modulator, and Arimistane is an Aromatase Inhibitor. No their effects are quite different.

  23. Sup Derek,

    I was thinking about running LGD with Cardarine and MK677 for 12 weeks. This would be a recomp cycle, as I would like to drop some body fat, yet still maintain or maybe add a little size. After words, I’ll still continue to run MK677 as a PCT. I’ve read through many forums that there’s no need for such PCT like Clomid or Noval and you recommended ArminRX for 4 weeks max. Would any testboosting Pct work like HCgenerate though that’s more on the expensive side. ArimRX would be what I’d like to go with but I wanted to make sure there’s no need for Clomid or Nova.

    1. I have no idea what HCgenerate is so I couldn’t say.

      Clomid or Nolva is used if you are definitely suppressed and want the “safe” PCT. It will work better than anything over the counter you could use, but obviously some individuals prefer to steer clear of Rx PCT compounds, so they prefer the Arimi-RX as it is over the counter and 100% legal.

      Ultimately it will come down to your personal choice of what you want to use. Arimi-RX is perfectly sufficient for mild cycles or for those are aren’t prone to suppression. If you are very prone to suppression, have a hard time recovering, or are using very suppressive compounds, you may want to go the Clomid + Nolva route.

  24. Derek, thank you for all of this info, it is terrific. I wanted to try LGD4033 and would follow it up with Arimi Rx PCT. Does this sound ok to you? When would I start the PCT? Do I need any liver support?

    1. Ultimately it will come down to your personal choice of what you want to use. Arimi-RX is perfectly sufficient for mild cycles or for those are aren’t very prone to suppression. If you are very prone to suppression, have a hard time recovering, or are using very suppressive compounds, you may want to go the Clomid + Nolva route for PCT, but Arimi-RX is typically sufficient for solo-compound cycles.

      The Arimi-RX protocol is outlined in the article, PCT starts the day after your last SARM dose.

      SARMs aren’t liver toxic no you don’t need liver support.

        1. Also, MK677 is on backorder. In the article you say to take 25 mg a day. Is it necessary or can I go with the LGD and PCT for my first try?

          1. Of course. LGD solo will still produce solid gains with a good diet and training regimen.

  25. One hopefully last question, is it fine to have a few weekend cocktails while on this cycle? As long as my diet is good?

      1. Point taken. In the example above you say to take 1 pill of Arimi-RX PCT for weeks 1-12. Is this correct? It also says above that to start it for four weeks after the LGD cycle.

        1. Derek, can you please help me with this? I want to be sure I understand what to do
          In the example above you say to take 1 pill of Arimi-RX PCT for weeks 1-12. Is this correct? It also says above that to start it for four weeks after the LGD cycle.
          Also, do you recommend a fat burner and if so which one? Thank you in advance for your advice.

          1. Yes it is.

            For a fat-burner, CODE RED is pretty solid. You can get it here: CODE RED discount code “DC15” will save you 15% on your purchase.

          2. So 1 pill a day of Arimi for the whole cycle of LGD and continue with Arimi for 4 weeks after the cycle?

  26. Hi derek i was going to use LGD and mk677 together but i realized i cant take mk677 becayse i am a diabetic and mk677 is horrible for blood sugars… LGD is the only thing i can take now

    If i take LGD only w/o mk677 will i still make good gains? how much will i be missing out from mk

    and what about mk2866 instead of mk677?

    thank you derek i love your content

    1. If your diet and training are in check then yes.

      Your second question is unanswerable.

      I’d rather run something else than Osta would LGD.

  27. Background
    24/M
    6 yrs lifting experience / 2-3yrs intense.
    Weight: 185
    BF%: 7-10 measured 3-site calipers
    No prior use of PEDs

    Plan of action: 4wk “Test”
    Coming up to the end of my natural cutting cycle, I’d like to try SARMs for the first time.

    20mg/day wks 1-4: Ostarine
    10mg/day wks 1-8: Cardarine
    3 pills/day wks 5-8: Arimi Rx (PCT)

    If no abnormalities/issues arise I plan on using LGD to assist in my bulking cycle.

    Plan of action: 12wk Bulk
    After finding my new TDEE (1-2months off)

    10mg/day wks 1-12: Ligandrol
    1 pill/day wks 1-12: Arimi Rx
    3 pills/day wks 13-16: Arimi Rx (PCT)

    Nolvadex on hand if needed.
    Possibly adding Cardarine in during wks 10-16.

    How does this look for a first time SARMs cycle? Any critiques/input is highly appreciated.

    Thanks!

  28. Derek, once again thank you for your site and comments. MK677 is back in stock but looks like it is 10mg per pill. You say take 25 a day before bed. Is it 2 and split one? It is hard to read the label on the enhanced athlete site. Also if I train at 1 p.m. is it ok to take with LGD and Arimi in the a.m.?

    1. I use 30mg of EnhancedAthlete MK-677 when I take it. You can split one up ya, but I prefer to just have 3, more convenient.

      Yes that’s fine.

  29. im trying to start my first LGD cycle. should i do 8 weeks or 12 weeks?

    Do i need Arimi-Rx on hand just to avoid gyno? should i take one pill daily for my cycle?

    is my pct okay?
    clomid 50/50/50/50
    gw-501516 20 mg day

  30. Derek – I used your Code on a 500$ order of MK677 – LGD – clomid / nolva + Yk11 for 12 weeks – just a heads up:)

    Question: Ive been using 10mgs of LGD for close to 4 weeks now, started 6/26/2017 – and I dont really feel that many effects. Possibly muscle fullness, maybe a little strength increase..but it seemed like Ostarine at 20mg had more of an effect alot sooner.
    (also using Yk11 at 10mgs daily, + 20mgs of MK677 daily)

    —soo do you see LGD taking longer to really kick in? Or should I up the dose?

    Stats: 6’2 / 200lbs , lifting for 7 years / 12-17% BF.

    Thanks – im always using your codes.

    1. Hey Eric.

      You didn’t mention anything about your diet. Are you eating in a calorie surplus? Are you getting in enough protein? Are you bulking or cutting or what are you doing right now goals wise?

      You won’t gain any muscle no matter what drugs you’re on if you’re not eating enough.

      1. I guess im doing the not-so-favored approach, of a sorta recomp. not full blown bulk, but more of a slight caloric surplus – maybe around 200+ calories.

        Protein intake is 200g a day minnimum.

        When I was on osta- it seemed like I felt large strength gains quite quickly, and was expecting similiar results with LGD.

        Do you know if one compound typically takes longer to kick in than others, or is it really an equal thing – just more diet / training based?

        Thank you for the responses!

        1. After 4 weeks it would’ve kicked in by now. Maybe your body just doesn’t react well to the compound. Stick with what works for you, not everything works the same for everyone, for example you might just respond better to Ostarine than LGD. Find what works best for you and stick with it is my suggestion. The issue could just be not enough calories and protein too seeing as you are attempting to recomp which isn’t the most favorable scenario for size and strength gains.

  31. So let me get this correct: If I only run LGD for 12 weeks @ 10mg/day. I can just run Arim-RX @ 3 pills/day for 4 weeks for my PCT correct? BUT if I stack 2 or more SARMS I need to PCT with Nolva and Clomid of 50/50/25/25 for 4 weeks?

  32. Hey Derek, thank you for all the information you put out for us. I am currently starting week 5 of my LGD cycle, went from 15mg daily to 20mg in week 3. I have not noticed side effects yet or much of any suppression so far but I was wondering if blue ox might be a good stack with 20mg of LGD compared to Arim-rx.

    1. No, Blue Ox won’t do a thing for you on cycle. The Arimi-RX is to keep your estrogen to test ratio more favorable, nothing more. You can’t prevent the suppression you will experience, you can only put yourself in a better position to mitigate potential side effects, which is what Arimi-RX does.

  33. A little back ground I have been lifting for 7 years and gained over 50lbs since my journey began. Never used anything besides creatine and pre workout.

    Started a SARM Cycle, about a week ago. Osta-30mg daily and Mk-677-10mg daily. Also added Huperzine A. I bought a 6 week cycle of Osta and I’m thinking about getting a 6 week cycle of LGD.

    Should I run the 6 week cycle of Osta then immediately run a 6week cycle of LGD or should I take a week off (or more) between cycles and PCT.

  34. How’s it going? I just bought 2 bottles of LGD, 2 bottles of Osta muscle, 1 bottle of Arimi-RX, and 2 bottles of organ support from EA. I was going to stack LGD with Osta for 8weeks, but after reading all I can see is basically LGD is a weaker version Osta, right? I’m a hard gainer I’m 20yrs old, 5’9, and 155lbs. I told mk-677 for 3months straight. I just finished my last bottle. When I get off deployment I would like to do something with the SARMS I just ordered. Should I just go ahead and stack LGD with Osta? If no then should I run Ostarine then hop into LGD??? would I need a PCT after ostarine?? and if so do I really take one a day along with my stack?? or should I just take it post cycle after LGD? It’s all kind of confusing to me. Thank you for your help! Love your articles!!!

  35. Hi, amazing article. Im currently researching 5mg of LGD from EA every day. Nothing else.. would you recommend me to order the research PCT and begin that asap once a day and continue to research the PCT 3 times a day for a month after my cycle? Also, would there be anything wrong with moving to 10mgs from week 8-12? thank you.

  36. Hi Derek, love your articles and your videos. M planning on a lgd cycle later this winter after my osta cycle. Do I need a test base for lgd? Is 4 Andro or epi Andro better as a test base for lgd?
    Would be grateful if you would give your input please. Thanks

    1. No you don’t need a test base. The purpose of a test base is to prevent low test side effects from occurring on cycle if you are using a compound that will undoubtedly shut you down, or to get the benefits of test itself at a supraphysiological level. LGD shouldn’t shut you down unless you already have suboptimal hormone levels, so a test base wouldn’t be a necessity during an LGD cycle.

  37. Hey Derek,
    I have question I’ve ran lgd and mk 677 for 12 weeks and then got off and went to prohormone (1 andro and 4 andro) and now I’m back on sarms gonna do another 8 week cycle I’m doing lgd right now and Ordered some Rad 140 from EA . My sarms should still work ??even tho I didn’t take PCT because I laid off sarms for 8 weeks went to 1andro and 4 andro then went back to sarms so I allowed my receptors to recover because I heard you have to stay off sarms 4-6 weeks after running 12 weeks because if not you will have diminished returns (won’t work)

  38. Hey Whats up Derek, hey bro, first of all i truly appreciate your time and knowledge, ive been following EA for a long time and your YT channel aswell, ive been training for 9 years all natural and i think ive reached a good level, anyways, im planing to do my first SARM cycle in a couple of weeks, what would you choose/think is the best first SARM to start, im trying to gain some good 8-12 lbs of lean Mass, should i go with Ostarine 25 mg/40mg a day, or LDG 10mg/15mg a day, i want to get max results, so maybe 12 weeks?, and also what PCT would your recommend if i want to keep most size and of course recover my natural T (Maybe MK-677, Cardarine, Clomid etc), anyways bro, thanks in advanced.



    1. If you’re going to do 12 weeks then rotate anabolic compounds at the end of week 6. PCT go read my PCT article just use the search bar and it’s the first article I believe.

  39. Hey, man! Great work! I’ve been blasting through your articles and they have benefited me incredibly! I’m 17, thinking of giving my rat his first cycle. I’m competing in the NPC Pittsburgh Championships in Men’s Physique, Teen Division and 6’7″ division. My cycle starts Jan 6, taking 60 days of LGD and MK677 with 1 AI a day, then moving onto a 60-day cut of Osta, Cardarine, and 1 AI a day with a PCT of 3 ARIM-RX a day. Would I need anything more, as there’s 120 days straight of mild suppression or should just the one month do the trick? Also, would I need a liver gaurd? And Will my rat get any excess acne? Thanks, brotha!

    1. What is “1 AI”? Which AI, be specific. I’d do a proper PCT (checkout my PCT articel to see what I mean). Acne I answered your other comment.

  40. Excellent post mate, you’ve answered a million questions. I’ve been training for a while now and know quite abit about training etc, weighing 6’0 at 210 pounds, relatively leanishbl but looking to recomp. I know about calories at bulk/cut but I never seem to be able to get an idea if where you eat at to recomp – isit at maintenance? Cut calories? Some would say I should cut but if I have the option with SARMS to continue adding muscle while shedding fat why not! Thanks in advance. And yes, I’m a man.

  41. Hey Derek!

    Read some recent articles of you about PCT after a Sarm Cycle.
    In the post you stated the better safe than sorry method where you outlined a PCT Protokoll with Novaldex and Tamoxifen.
    In this Post specifically relating to LGD you said that 3 Pills of Arimistane would be sufficient.
    Kinda confused what to do now.
    Also wanted to ask, how long should you pause between Sarm Cycles.
    Can I Bulk with LGD for 10-12 Weeks, top it off with a PCT and after that continue with a Ostarine Shredd (maybe 8 weeks?)?
    Last question would be: bulking and cutting on SARMS, how should I change my nutritioning?
    (can I go with the regular “bodybuilding” habits?)
    Thanks for your Answers! Really appreciate you and your knowledge !

    1. The most recent PCT article reflects the accurate up to date information.

      For how long you should take off between cycles:

      What your diet should be comprised of is impossible to answer in a general blanket statement, but at the end of the day when bulking you are in a calorie surplus, and when cutting you are in a calorie deficit, how you allocate your macronutrient ratios at those particular caloric allotments will depend on your body composition, energy requirements (type of workouts, work, lifestyle), metabolism, etc. In general, when I’m bulking I eat the exact same foods as I do when I’m cutting, except I eat a greater quantity of them, opt for more calorie dense cuts of meat, and taper up my carbohydrate intake in order to taper up my calorie intake.

  42. Hey Derek,
    How would you measure exactly 25 mg of MK-677 when using the liquid version? I understand that in 1ml there is 20g and in 0.25ml there is 5mg. I am not sure how to measure the 0.25ml correctly.

  43. HEy derek im on cycle rugby now for 12 weeks : 30 mg mk677 a day
    10 mg YK11 a day
    10 mg of lgd a day
    And i take once pill of Armi-RX pct during the cycle , should i take more armirxpct if i see a little gyno growing like 2 pills a day ? One am one pm ? Or just one am ? Im prone to gyno , i already have a surgery on it (after the 12 weeks i m gonna do a pct with clomid and nolva)

    1. If you have Gyno symptoms then yes you’d need to increase Arim-RX dosage. You may need to jump up to a stronger AI like Aromasin if you still have issues while on 75mg of Arim-RX per day (unlikely).

  44. Hello DC! First I want to thank you for the great info here and at your YouTube channel! I’m from Brazil and got thrilled with all the great info that you freely give us. Before my question a little bit about my stats. 1.86meters 90kg bf around 15%, more like an ecto-meso frame and 40y old:. Had blood test two most ago, here some data’s: lipidic profile: HCL 57mg/dL- total cholesterol 197mg/dL and LDC 126mg/dL. Hormones: testo 826, prolactin 5,1, T4 0,94, Dhea 1,8. My goal it’s to get around 95kg with 10-12bf.
    With that being written my only question is: which is the better choice for me, Lgd or osta? Im very concerned with suppression though. And also presenting some small pain in the knee articulation shoulders and sometimes elbow. I’m very natural, never used roids just basic supps. I’m lifitig for 15 years but never had compromised and with free time because of the studies and job. Now that really can focus in lifting wheigts and get a nice shape
    A huge regard from Brazil !!!

  45. ive gotten a lot of mixed responses on how to pct ostarine. It seems like there’s a good amount of people w some form of suppression….what pct would you recommend for ostarine only for my test subject’s first run through? and would adding lgd be overkill?

    1. Also, the more I research, the more it seems like ostarine is somewhat ineffective….even though lgd is pretty strong, do you think it would be okay to run it on the first cycle?

  46. Hi Derek,

    what would be the right cycle for building back my kneecap cartilage? I do have a slight chondromalacia. Was thinking maybe for a 12 week cycle of Osta (@10mg), LGD (@5mg) and MK677 (@20mg). Then 4 weeks PCT with Clomid, and then if needed one more 12 week cycle.

    Combination of the 3 in order to tackle every angle to the problem …
    Does it make sense?
    thanks

    1. I don’t have much experience with using SARMs to heal injuries. If I were you if your only goal was to fix your knee, I’d look into BPC-157 and TB500 instead.

      1. Thanks! Never thought of petpides. Did a quick search on Internet, they do look promising!

        Still, as they require poinning and i do travel (flying) a lot i think i will give SARMS the first shot as carrying needles around is not easy,

        I think both Ostarine and LGD have a proven record of healing and increasing bone mineral density, plus MK677 increases GH which is vital for cell proliferation.

        I will be happy to post the results of my cycle once done to inform/educate other people with similar “defects”.

  47. Hi Derek

    So I am thinking of keeping things very simple for my first cycle and taking LGD 4033 at 10mg per day in the morning for 12 weeks. And then I will run Arim-RX taking 3 capsules per day for 4 weeks after for PCT. I have done a lot of research into the compound and how it effects your body and where it is most effective, and like you said 10mg seems to be the so called ‘sweet spot.’

    My question is if i were to up the dose to 15mg or potentially 20mg at week 5 or any week during the cycle, what effects would I be likely to experience and would it even be massively beneficial to up the dose or is it just simply a waste of money as it is my first cycle. Also, by upping the said dosage would this effect what is needed for a suitable PCT.

    Thank you very much for all the information you have provided, I look forward to hearing a response soon 🙂

    1. If you increase the dosage then as you would expect the benefits would likely increase, as would the potential for side effects.

      What you use for PCT is ultimately your own judgment call, read this article first and then make an assessment based on your own individual pre-cycle bloodwork, age, how suppressive what you are using is, the dosage used, the duration of use, etc.: https://moreplatesmoredates.com/pct-and-ais-for-sarm-cycles/

  48. Hi Derek.
    If you have to choose between this sarms and s23 for the biggest mass building, which one do you prefer?
    Tx😊

  49. Hi Derek,

    I have been running LGD 4033 for just over 2 weeks now at 10mg per day and I am already encountering problems with suppression. Lets just say my sex drive has dropped compared to how it used to be and when it does go up its never fully up if you get what I mean…

    Is there anything I can take on cycle (like Arim-RX PCT) to counteract this and since I am encountering these problems already will this effect what I should use for my PCT?

    1. You can’t offset suppression or counter it. All you can do is replace the physiological benefits provided by endogenous testosterone in the absence of it with an exogenous test-base, but that is something most guys reserve only for more intensive cycles that have compounds in them that result in full shutdown.

      Yes I’d consider a more intensive PCT seeing as you evidently have a high propensity to suppression, or just didn’t have strong baseline pre-cycle hormone levels to begin with.

      1. Thanks for the reply Derek,

        I will carry on with the cycle and depending on the relative side effects of suppression I may consider a nova/clom PCT.

        Thanks again

  50. I got a question, if I plan for my lab rat to use arimi-rx as AI, can arimi-rx also be used as pct afterwords?

    Great article!

    1. It can, but you should refer to my PCT article first to read about the scenarios in which I’d consider a stronger PCT more of a necessity just in case (type PCT in the search bar, first article).

  51. Great read, great info.

    Did a few cycles of OSTE and reacted great to it and I’m fuckin’ pumped to start this LGD 4033.

    I purchased the 100 ML bottle and this is the first time I’ve used a SARM that’s liquid form.

    ill be using 10gs a day.. how many 100ML bottles do you guys go through at the 10gs a day?

  52. Thank you for the great article. I have just purchased LGD-4043 from PP. I want to be ready with my Nolvadex + Clomid. I can find the SARMS everywhere, but I am having trouble finding those. Where is a solid place to get them?

  53. If you take LGD-4033 for 8 weeks at 5 mg per day, how long will it take for the substance to leave your system completely? I.e. drug testing etc.

  54. Hi derek! Thanks for answering all the comments. I have started bulking sarms cycle
    Lgd 4033- 10 mg/ day
    RAD 140- 20mg/day
    Yk-11 – 20mg/day
    1) How does the cycle look to you for bulk?
    2) how long does it take to see the effect of sarms on body composition and to actually feel some strength and lean mass gains?
    3) On a caloric surplus how much weight gain should I expect to see on scale per week? Does the recommendation of weight gain(500gm/week) remains the same for a natural vs someone who is on sarms?

      1. Sorry, what I meant was, is it likely the increase in testosterone with the addition of ligandrol will necessitate using an estrogen blocker to prevent side effects?

  55. Derek,

    Thanks for all the information. I’m a few days into my first lgd cycle. I’m starting off with 5mg doses and I’ve started to notice chest pains / tightness of chest. Have you ever heard of this? I bought from Proven Pep. My diet is clean and I’m not taking any other medication. Thanks for your input?

      1. systolic BP: 120
        diastolic BP: 81
        HR 101.

        The blood pressure is pretty normal for me. Never really paid attention to what my resting HR was, but 101 seems high. by water, do you mean dehydration? Im usually pretty good about that.

        Some other forums have said that the chest pains are Acid Reflux, but its all anecdotal evidence/bro science with AAS and Sarms info lumped together (link below). Otherwise I’ve had a hard time tracking down credible info that supports that its acid reflux. The solution the sarm is dissolved in is polyethylene glycol 400, which sources say is pretty low in toxicity.
        https://www.isarms.com/forums/steroids-sarms-information/acid-reflux-4211.html

        I stopped the cycle on the 5th day b/c of chest pains. Its been two days since then and the chest pains have almost completely subsided, I expect they’ll be completely gone in another two days. Kinda bummed since I was looking forward to trying out this cycle, so any tips/suggestions/info is greatly appreciated. Thanks

        1. Just to clarify, the values I gave were taken on the 3rd day of my cycle, the same day I started to notice the chest pain. They were also taken in the middle of the day at my office and I sit at a desk all day, so there was no extraneous activity before the testing.

          1. BP is fine, resting HR is way too high. Would’ve been good to have a baseline so you could compare. I’d drop it and see if it goes away.

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