RAD140 Review

RAD140 (Testolone) – Results, Clinical Trials & Reviews

RAD140 is a selective androgen receptor modulator (SARM) currently under development for potential use in treating muscle wasting disorders and hormone-receptor positive breast cancer.

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What Is RAD140?

RAD140 is a selective androgen receptor modulator (SARM) developed by Radius Health, Inc.

There are several unofficial slang terms for RAD140 in the fitness community, one of the most popular being “Testolone”.

RAD140 has all of the hallmarks of an effective SARM, exhibiting a high affinity for the androgen receptor with tissue selective anabolic effects in muscle in bone, with a relatively minimal effect on prostate, seminal vesicles, and other androgen affected tissues [R].

RAD140 has a high level of oral bioavailability and demonstrated high in vivo tolerability [R].

It is still in the preclinical stages with recruitment occurring right now into its first phase 1 human trial, and has yet to be tested on humans [R].

In addition, it is often referred to as a potential alternative to testosterone replacement therapy in the recreational bodybuilding community.

Its potential efficacy in a hormone replacement therapy context is implied in some of the preclinical animal data, but the scientists also acknowledge the potential limitations of RAD140 when considering it being used in this capacity.

Its lack of aromatization is all that is needed to make a definitive judgment on its overall efficacy profile as a hormone replacement therapy alternative, which I will delve into later.

Recreational users are quick to label RAD140 as the “safe non-steroidal version of testosterone.”

This is because it doesn't require injections and hasn't exhibited any notable side effects in its preclinical data.

Obviously with no human data, it is extremely presumptuous to make a statement like this, and later in the article I will delve further into the limitations of RAD140, and SARMs in general.

RAD140 is purported by many to be a very versatile SARM that provides a complete replacement for testosterone replacement therapy (TRT), without any of the side effects.

Mechanism Of Action

RAD140 doesn’t require any injections as it has a high level of oral bioavailability [R].

After ingestion, RAD140 binds to androgen receptors in different tissues in the body which a high level of selectivity.

After binding to the androgen receptors, RAD140 exerts tissue-specific anabolic effects in muscle tissue and bone, and neuroprotective androgen-like effects in the brain, with a relative lack of stimulation in prostate and seminal vesicles [R].

RAD140 is a potent androgen agonist in the levator ani, and is also a much weaker partial antagonist on the seminal vesicles and possibly the prostate.

RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM) [R].

To put this in perspective, the affinity for the androgen receptor for Testosterone in this preclinical model was 29 nM, and 10 nM for DHT.

In other words, RAD140 has a greater affinity to bind to the androgen receptor than Testosterone and DHT.

RAD140 does not aromatize into Estrogen, and does not undergo 5-alpha reduction into a more androgenic metabolite.

One thing that needs to be noted is RAD140's preclinical characterization referring to it as a “partial antagonist” in androgen affected tissues [R].

While this implies it is much less androgenic than all other SARMs, this is not necessarily the case.

Most other SARMs are classified as “partial agonists” in androgen affected tissues, and while RAD140 is classified in its preclinical profile as a partial antagonist, partial agonists may also be considered ligands which display both agonistic and antagonistic effects in affected tissues [R].

This is important because at a first glance the majority of readers will assume that RAD140 is the only SARM that has antagonistic effects on the prostate gland, and is therefore the most viable candidate for SARM therapy to date, which is not necessarily the case.

All androgen receptor ligands that have extremely selective functions indicative of a SARM have demonstrated partial agonist activity in the prostate gland, RAD140 included, despite what its preclinical profile may imply.

RAD140 Effects

Increases Muscle Mass

RAD140 is very potent at low dosages and exhibited a mean weight gain of more than 10% in 28 days at only 0.1 mg/kg in a preclinical primate model [R].

RAD140 Preclinical Primate Model

In a preclinical rodent model assessing the efficacy of RAD140 in comparison to exogenous Testosterone Propionate, RAD140 significantly outperformed Testosterone in myotrophic/androgenic selectivity.

In this study, rats were castrated and either given placebo, 1 mg/kg of Testosterone Propionate or graded dosages of either 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg or 10 mg/kg of RAD140.

The “sham” group are untreated rats that weren't castrated that serve as a reference guide for how much anabolic/androgenic activity occurs in a normal healthy rat with normal endogenous Testosterone and DHT levels.

After castrating the rats, muscle mass and prostate size decrease because there is no longer sufficient androgen stimulation occurring in the body, as there is no Testosterone or DHT being produced.

By using RAD140 or Testosterone, this study exhibits exactly how effective these two compounds are at replicating the anabolic activity necessary to maintain normal amounts of muscle and bone mass, and how much androgenic activity will occur in the prostate relative to that.

By referring to the figure above you can see that the lowest dosage of RAD140 capable of maintaining normal levels of anabolic activity in the body was the 0.3 mg/kg treated group.

While Testosterone at 1 mg/kg was able to outperform the 0.3 mg/kg RAD140 group in muscle growth, it stimulated prostate growth as well to a much greater extent.

For therapeutic purposes, RAD140 exhibits a greater efficacy profile at low dosages than Testosterone, as it's able to maintain normal amounts of muscle mass, but greatly decrease the amount of androgenic activity in the body.

The 3 mg/kg RAD140 treated group was able to replicate the same level of muscle tissue growth as the 1 mg/kg Testosterone treated group, with about half of the androgenic activity in the prostate.

It would be interesting to see how the same Testosterone treated group would respond if they were given Dutasteride to inhibit the 5-alpha reduction of Testosterone into DHT, and if that group would still exhibit a less favorable selectivity than the RAD140 groups.

For all we know, it could be more beneficial to use Testosterone concurrently with a 5-alpha reductase inhibitor rather than RAD140, especially considering Testosterone aromatizes into Estrogen, which is a severely limiting flaw of SARMs in general, but that all remains to be seen.

In a therapeutic context, RAD140 looks very promising based on the preclinical data given, and it blatantly has the ability to selectively increase muscle tissue, even at supraphysiological levels.

Fat Loss

No direct fat loss was noted in the preclinical trials conducted on RAD140, however, as a human accrues more muscle mass, their basal metabolic rate will increase in parallel.

This is a given, therefore anything that can increase lean muscle mass in a human would theoretically increase total daily energy expenditure.

The net result of that would be an increase in the amount of calories expended just by having more muscle tissue via RAD140 usage, and greater overall fat loss.

Therefore, it is very likely that RAD140 can indirectly increase fat loss to some extent, dependent on the amount of muscle growth it induces.

Increases Bone Mineral Density

All SARMs that have reached human trials have shown the ability to inhibit bone turnover, stimulate bone formation, and retain bone mineral density in a state of catabolism [R].

While RAD140 hasn't gone into human testing yet, its tissue selective anabolic effects in bone have been demonstrated in preclinical animal models [R].

As exemplified via other more thoroughly studied SARMs like Ostarine and LGD-4033, these effects will very likely translate in humans just the same in further clinical trials.

Reduces Prostate Size

RAD140 has proven capable of exhibiting tissue selective anabolic effects in muscle and bone equivalent to that of a therapeutic dosage of Testosterone while simultaneously reducing prostate size by approximately 70% [R].

RAD140 has a much lower level of androgenicity in the body and simultaneously suppresses natural Testosterone production.

The net result of this in hypogonadal males would be a fulfilment of Testosterone's important functions, with a lack of androgenic activity.

The net result of this in healthy males with normal testosterone levels would be a drastic decrease in prostate size and androgenic activity, in parallel to natural testosterone suppression.

The reason being that healthy men still operate with a significant amount of androgenic activity occurring via their natural Testosterone production and its 5-alpha reduction to DHT.

When a healthy male has their endocrine system suppressed, they will produce less Testosterone (and consequently DHT as well), which will cause a dose dependent decrease in muscle size, bone mineral density, prostate size and the size of seminal vesicles.

This is what makes RAD140 and other SARMs so interesting, as they will suppress the endocrine system and can reduce systemic androgenic activity, while keep anabolic activity exactly the same, or even increasing it to supraphysiological levels, depending on the dosage used.

There are a variety of therapeutic applications in which a very selective potent agonist in muscle tissue with a far lower level of androgenic activity would be beneficial in a clinical setting, with just one of those being a potentially viable treatment for benign prostatic hyperplasia in men.

Neurodegenerative Disease Protection

SARMs target androgen receptors in different areas of the body, and RAD140 has also shown neuroprotective effects in the brain of androgen deficient rats [R].

Endogenous androgens are responsible for several important functions in the body and brain, the majority of which are mediated via androgen receptor activation [R].

In hormonally deficient rats RAD140 activated those androgen receptors in the brain and prevented neurodegenerative disease progression from occurring in the absence of sufficient endogenous androgens.

RAD140 was able to activate androgen receptors in the brain, protect hippocampal neurons from cell death, and induce anabolic activity in muscle tissue and bone as effectively as Testosterone, all with a near complete absence of stimulation in androgen affected reproductive tissues [R].

Suppresses Breast Cancer

The androgen receptor is frequently expressed in many estrogen receptor (ER)-positive, ER-negative, and triple-negative breast cancers.

As RAD140 facilitates its effects via the androgen receptor, assessing its potential clinical applications in this context was worth exploring.

In a preclinical study RAD140 significantly suppressed the growth and proliferation of breast cancer cells in in vivo and in vitro models of AR/ER+ breast cancer [R].

RAD140 has a promising preclinical profile, and Radius Health is currently in the process of recruiting 40 postmenopausal women with hormone receptor positive breast cancer into its first phase 1 clinical trial on humans [R].

The main goal of the study is to evaluate its safety profile, tolerability, and pharmacokinetic characteristics in hormone receptor positive breast cancer.

RAD140 Pipeline
RAD140 Pipeline

RAD140 Clinical Trials

Phase 1

One Phase 1 study on RAD140 has been conducted [R].

The Phase 1 trials are the first stage of testing in human subjects designed to assess safety, side effects, best dosage, and formulation method for the drug.

Dose Escalation Study In Estrogen Receptor Positive, HER2 Negative Breast Cancer

The first Phase 1 trial involving RAD140 was a dose escalation study with a 3 + 3 design conducted in 2017 on 16 postmenopausal women with hormone receptor positive breast cancer.

The primary objective was to determine its safety profile and the maximum tolerated dose of RAD140.

The secondary objectives were to evaluate pharmacokinetics and antitumor activity.

The median age of the 16 patients enrolled in the trial was 58 years old.

88% of them had visceral disease and 94% had androgen receptor positive tumors determined via immunohistochemistry.

6 patients were given 50 mg RAD140 orally once per day.

7 patients were given 100 mg RAD140 orally once per day.

The other 3 patients were given 150 mg RAD140 orally once per day.

The median time on treatment was 8 weeks, with a range of 1-25 weeks for the entire group of patients.

Over 30% of patients experienced an elevation of their ALT/AST levels, decreased weight/appetite, and constipation.

Dose-limiting toxicities (all grade 3 and reversible) included hypophosphatemia and elevated ALT/AST.

2 patients experienced hypophosphatemia, and they were both in the 150 mg dosage group.

2 patients in the 50 mg and 100 mg dosage groups experienced elevated ALT/AST.

No drug-related deaths occurred.

There was 1 partial response in the 100 mg dosage group and 2 patients with stable disease for over 12 weeks.

The time to partial response was 15.9 weeks and the duration was 8.6+ weeks.

SHBG levels decreased in all 12 of the patients evaluated.

PSA levels increased in 10 of the 14 patients evaluated, with the most notable increase occurring in the patient with a partial response to RAD140 treatment.

That patient remained on the treatment at the 7 month mark.

The provisional maximum tolerated dose of RAD140 was determined to be 100 mg dosed once per day orally.

Overall, RAD140 demonstrated an acceptable safety profile and exhibited preliminary evidence of target engagement and antitumor activity [R].

Is RAD140 As Strong As Steroids?

Yes, kind of…

RAD140 purportedly (not officially) has an anabolic:androgenic rating of 90:1 and partially antagonizes the negative effects of testosterone on the prostate.

The anabolic:androgenic ratio is essentially a ratio which exhibits how much anabolic activity a specific compound will exert in the body, and how much androgenic activity it will exert in the body.

Anabolic, meaning that they promote anabolism (cell growth), and androgenic (virilization), meaning that they affect the development and maintenance of masculine characteristics.

The androgenic:anabolic ratio of a compound is a very important factor when determining the potential clinical applications of it.

Initial steroid research sought to synthesize a compound which retained a high degree of anabolic activity, coupled with a lack of androgenic activity, the goal being to produce a compound with a high anabolic yet low androgenic effect.

Because steroids were intended for medical treatment, patients could include men and women, and even children.

The last thing you want to do is give a girl a bunch of testosterone so she can prevent muscle wasting, only to have her end up with a myriad of masculinizing side effects like the deepening of her voice, acne, clitoral enlargement, body hair growth, and all the other negative side effects associated with anabolic androgenic steroids.

The androgenic side effects of steroids in men aren't insignificant either.

The risk of Gynecomastia (man boobs), endocrine shutdown (infertility), testicle shrinkage, negative effects on cholesterol, increased risk of heart disease, among many other side effects are all very real side effects of anabolic androgenic steroids.

I'm not saying that these will absolutely happen at all, but there is a chance of them occurring with steroid use, with some of them still occurring with SARMs to a significant extent.

Considering this, it is obviously very important to synthesize compounds that have as low of a risk of any of these side effects occurring, while still maximizing the anabolic efficacy of the treatment given to patients.

Compounds with a high ratio of androgenic to anabolic effects are the drugs of choice in androgen-replacement therapy, but in the context of muscle and bone wasting prevention, compounds with a much higher anabolic/androgenic ratio are exponentially better candidates for treatment.

Based on the preclinical data, RAD140 has shown that even with a complete absence of testosterone it can still induce just as much anabolic activity in muscle and bone as testosterone would, with several-fold less androgenic activity.

This would consequently eliminate and replace the need for anabolic androgenic steroid use in degenerative musculoskeletal disease treatment.

In addition, RAD140 synergistically works alongside testosterone to induce greater amounts of muscle growth in the body if they are used concurrently, while simultaneously decreasing testosterone’s negative side effects on the prostate [R].

Testosterone and RAD140 used concurrently

Is RAD140 The Strongest SARM To Date?

This is debatable as different SARMs act on the androgen receptor in different ways in different individuals.

In general, it is undeniable that RAD140 is very strong, and pound for pound it is one of the strongest SARMs on paper with a purported 90:1 anabolic:androgenic ratio.

It is formidable to LGD-4033 in terms of strength gains, although LGD-4033 seems to be a more potent overall muscle builder.

RAD140 seems to have a muscle hardening effect that isn't commonly reported with LGD-4033.

Increased muscular endurance from RAD140 is also reported to be one of its most redeeming traits.

The only SARM that seems to outperform RAD140 in terms of muscle building, strength gains, and muscle hardening simultaneously is S23.

However, S23 is more suppressive and has some odd side effects that aren't reported with RAD140.

RAD140 Reviews (Anecdotal/Recreational Reports)

RAD140 is one of the most popular SARMs in the fitness and bodybuilding community in the context of performance enhancement.

It is most commonly used to gain muscle mass and increase strength.

It is reported to also be very effective at increasing muscular endurance and overall stamina.

While other SARMs help with muscular endurance to some degree, RAD140 in particular seems to excel in its ability to increase endurance, stamina and speed.

This is not to be confused with Cardarine and SR9009, which are not SARMs.

RAD140 is not as effective as Cardarine at increasing cardiovascular endurance.

RAD140 is most commonly used for bulking, or in recomposition phases, and is often referred to as a dry gainer.

It creates a harder, dryer look similar to SARMs like S4 and S23.

Users often report a very noticeable aggression unique to RAD140 that is not notable in any other SARM except S23.

This increased aggression has made RAD140 a fairly popular pre-workout alternative in the bodybuilding community.

RAD140 Dosage

Dosages of 10 – 30 mg per day are commonly used in a recreational context for muscle building purposes.

There is no established therapeutic dosage of RAD140.

RAD140 Half-Life

Pharmacokinetic samples collected for 144 hours after the 100 mg RAD140 single dose showed variable absorption with a half-life of approximately 60 hours [R].

The observed human steady-state pharmacokinetic exposure at 100 mg exceeds the pharmacokinetic exposure of the efficacious dose in mice of 10 mg/kg.

RAD140 Side Effects

One thing you will often read is how there have been no reported side effects of RAD140.

This is not the case, both anecdotally as well as in the limited clinical data.

Potential Ventricular Inflammation

Unpublished preclinical toxicology studies with RAD140 indicated that it induced focal inflammation of the right ventricle in male and female Sprague-Dawley rats [R].

With that being said, the same side effect was not noted in the male or female cynomolgous monkeys treated with RAD140, and preclinical rat models have some underlying issues in regards to cardiovascular risk.

Androgens cause 11beta-hydroxylase inhibition in rat adrenal glands.

Inhibiting this in rats causes an increase in the adrenal output of 11-deoxycorticosterone, which can cause cardiac lesions in rat hearts.

Also, in another preclinical rodent model, high dosages of RAD140 had a protective effect on the heart.

This was the first occurrence of rat cardiotoxicity reported for a SARM.

The data supports that the focal inflammation in the rat studies cannot be extrapolated to primates and humans, so it is very unlikely that this same outcome would occur in humans.

The fact that it didn't occur in monkeys with dosages as high as 1000 mg/kg/day is very reassuring that this outcome would be less likely to occur in humans, but it is notable nonetheless.

Hair Loss

While RAD140 exhibits one of the most impressive myotrophic/androgenic preclinical profiles, it cannot be ignored that there was still blatant increasing androgenic activity in a dose dependent manner in all animal models.

Albeit limited due to the high level of tissue selectivity, RAD140 still exhibits androgenic activity in the body and will potentially lead to accelerated hair loss.

However, it could also potentially reduce hair loss if used at a dosage that suppressed endogenous androgens and/or antagonized endogenous androgens at the androgen receptors enough that the androgen load on the body was lower than baseline, while still fulfilling the anabolic functions that would have otherwise been fulfilled via endogenous Testosterone.

This does not exclude temporary shedding (acute telogen effluvium) which can be triggered by a hormonal fluctuation.

This is not to be confused with androgenic alopecia, which is caused by follicular miniaturization induced by androgens.

Based on the efficacy data comparing S1 to Finasteride, it is likely that RAD140 (if anything) would reduce the progression of hair loss at therapeutic dosages based on its tissue selectivity [R].

Anecdotally, recreational users report hair loss quite fairly frequently with RAD140 usage, however, this is with dosages that likely greatly exceed what the therapeutic dosage will be in a clinical setting.

Whether this hair loss in the bodybuilding community is real androgenic alopecia or just temporary shedding is unclear and would require more data.


While the risk is relatively low based on anecdotal reports, it is safe to say that all SARMs can cause gynecomastia (gyno) as they impact the Hypothalamus-Pituitary-Testes-Axis.

By binding harder to the androgen receptors than endogenous androgens, there can be a diversion of more endogenous Testosterone to aromatize into Estrogen.

Also, suppressing Testosterone production in itself can cause an imbalance in the ratio of endogenous androgens relative to endogenous Estrogen in the body, creating a hormone imbalance that encourages gynecomastia development.

Estrogen management would be prudent during any usage of SARMs.

Lowering Of Lipids

Just like any other SARM or anabolic steroid, RAD140 exhibits a dose dependent lowering of lipids (LDL, HDL, triglycerides) [R].

One commonality among all anabolic androgenic compounds is that they will all suppress HDL cholesterol (“good” cholesterol) in a dose dependent manner, and this has been consistently demonstrated in clinical trials conducted on SARMs as well [R, R].

Every single SARM that has been evaluated has exhibited this same dose-dependent suppression of lipids.

Testosterone Suppression

Just like anabolic steroids, SARMs have all consistently exhibited suppression of luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the Hypothalamus-Pituitary-Testes-Axis.

The result of this is decreasing natural testosterone production in a dose-dependent manner [R].

Anecdotally, RAD140 is one of the most suppressive SARMs.

In a preclinical primate model assessing its effect on endogenous Testosterone production, young monkeys with testosterone levels between 600-800 ng/dL (similar to the average Testosterone level of 25-54 year old human males) were treated with RAD140 for 28 days.

In all treated monkeys, Testosterone levels dropped to about 50% of baseline, with the average Testosterone level decreasing to 200-300 ng/dL.

This occurred even with dosages as low as 0.01 mg/kg [R].

Increased Estrogen Or Decreased Estrogen

RAD140 does not aromatize into Estrogen, but it still has a large impact on the ratio of Testosterone:Estrogen in the body.

RAD140 binds to androgen receptors harder than endogenous androgens, and can encourage increased amounts of endogenous aromatization of Testosterone to Estrogen by occupying vacant receptor sites.

In addition, dose-dependent suppression of endogenous Testosterone levels can lead to a Testosterone:Estrogen imbalance.

The systemic elevation of Estrogen levels in the body is often misinterpreted as the result of prohormone laced SARMs.

High Estrogen Symptoms

  • Acne, oily skin
  • Erectile dysfunction
  • Low libido
  • Lethargy
  • Gynecomastia (man boobs)
  • Irritability
  • Depression
  • Water retention
  • High blood pressure
  • Enlarged prostate
  • Shrunken testicles
  • Sugar cravings

High dosages and/or long-term use of RAD140 can cause a decrease in systemic Estrogen levels.

This is facilitated through higher levels of endocrine suppression.

Estrogen facilitated physiological functions in the body are mediated through the aromatization of Testosterone into a sufficient amount of Estrogen.

If RAD140 usage suppresses endogenous Testosterone levels too low, it can result in Estrogen levels dropping as a consequence of the lack of aromatization occurring in the body in a suppressed state.

When Estrogen levels get too low, a new set of side effects can occur.

Low Estrogen Symptoms

  • Dull weak orgasms
  • Dry skin and lips
  • Dehydration
  • Erectile dysfunction
  • Low libido
  • Irritability
  • Mood swings
  • Loss of appetite
  • Fatigue
  • Lethargy

Liver Toxicity

Even at dosages 10 times higher than the efficacious dosage required to replicate the therapeutic anabolic benefits of Testosterone, RAD140 did not increase liver enzymes or exhibit any liver toxicity [R].

While this was just a preclinical animal model, it is promising for the development of RAD140 as other SARMs have shown potential liver toxicity concerns, albeit minimal at their therapeutic dosage amounts.

Increased Aggression

RAD140 users commonly report very blatant increases in aggression.

While this is anecdotal, it has occurred consistently enough in the bodybuilding community that it should be considered.

The interesting thing about this is that typically increased aggression only occurs when androgen index increases in the body.

This is why more androgenic steroids are commonly used pre-workout for a quick boost in aggression before training.

The fact that RAD140 is resulting in increased aggression in recreational users could potentially be indicative of some of the following outcomes:

  • RAD140 isn't as selective for anabolic activity relative to androgenic activity in humans as it was in the preclinical animal studies
  • The dosage humans are using recreationally is far higher than needed
  • Their RAD140 is fake and is another hormone entirely

I believe the second potential outcome is the most likely reason.

Potential As A Hormone Replacement Therapy (HRT) Alternative For Men

RAD140 is often labeled in the recreational fitness and bodybuilding community as a potentially safer HRT alternative for men.

This has yet to be proven in clinical trials, and there is one massive inherent flaw that prevents RAD140 from being a standalone effective HRT alternative.

That is its lack of aromatization into Estrogen.

RAD140 does not aromatize into Estrogen, and also greatly suppresses endogenous Testosterone levels.

The net result of this is suboptimal Estrogen levels to support basic physiological functions in the male body, and a myriad of low-estrogen side effects with long term use.

Even if RAD140 was a viable alternative to Testosterone, it would either need to be used in conjunction with exogenous Testosterone, or Estrogen would need to be administered concurrently with RAD140.

RAD140 is not a viable standalone treatment for hormone replacement therapy.

While high levels of Estrogen can cause numerous negative side effects, low Estrogen levels can be just as deleterious in men.

RAD140 Bulking Cycle

In a calorie surplus RAD140 will promote more lean muscle gains than would otherwise be possible to gain naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users.

MK-677 (Ibutamoren) and SARMs like S23 or LGD-4033 are commonly stacked alongside RAD140 in more involving performance enhancement bulking protocols.

RAD140 Cutting Cycle

In a calorie deficit RAD140 will retain much more lean muscle mass than would otherwise be possible naturally.

For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user's individual timeline constraints for reaching a goal body fat percentage).

Cardarine (GW501516) and SARMs like Ostarine (MK-2866) or S4 (Andarine) are commonly stacked alongside RAD140 in more involving performance enhancement cutting protocols.

In less common cases, SARMs like ACP-105, AC-262536 or LGD-3303 are stacked alongside it.

RAD140 PCT (Post Cycle Therapy)

RAD140 is very suppressive and undoubtedly requires a PCT phase (post-cycle therapy) for efficient recovery.

The goal of a PCT phase would be to restore natural Testosterone production as quickly as possible and prevent low androgen or high Estrogen side effects from occurring.

Forgoing PCT will greatly increase the risk of muscle loss, fat gain, among all of the other negative side effects associated with low Testosterone levels.

How much time off should be taken after PCT should not be determined with the bro-science “time on = time off” equation, rather it should be dictated by individual specific factors and blood work.

Buy RAD140

Most RAD140 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.

I strongly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.

These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure RAD140:

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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163 thoughts on “RAD140 (Testolone) – Results, Clinical Trials & Reviews”

  1. Do you think it would make a difference to go on a 4 week ostarine cut with rad-140? Certainly will be running 12.5mg ostarine ed during the cut as last time I saw great results on 25mg, was recomping even on ~2000 calories a day, though the suppression was decent.
    Will rad-140 be worth it to run on a 4 week cut?

      1. I’m currently on prescribed TRT my baseline Total T levels were 115

        I’ve been on TRT for 6 months and want to run a cycle of RAD 140

        1. Will I need a PCT if I am already on TRT?

        2. I take 1mg of anastrozole split up per week to keep my estrogen at bay

        3. My Total T on TRT is around 900-1000

        4. Anything you think I should change or will I be okay combining the two with no PCT etc.

  2. awesome article man, question currently training for my powerlifting meet. Im currently taking LGD with 677 and having great results. The meet is going to be in some time and im deciding on whether i should use RAD or LGD for strength gains any suggestions on which works better?

    1. Well if you’re already on LGD then the question sounds more like should you add RAD onto that or not. For strength gains alone, LGD and S4 are the best imo. The intramuscular fullness the MK-677 provides is good for joint lubrication and avoiding getting injured as well with heavy weights.

      For pure strength, LGD and S4 are the best probably, with RAD-140 in a close second.

  3. Hello, I want to try rad 140-30 mg/day for a period of 12 weeks .
    What can I add 7-keto dosed at 200 mg/day for 12 weeks of the treatment or add it during the pct? is it possible to add nicotinamide riboside for better gains? Thanks bro

  4. What’s up Derek. I am looking into starting a cycle of YK11 and RAD140 for possibly 8-10 weeks. What is your opinion on this stack P.s I have never dipped into anything like this before and my buddy just got off that stack and recommended it to me as I saw he put a good amount of muscle gains

    1. This isn’t similar to RED-PCT at all. RED-PCT is a testosterone booster, this is is a selective androgen receptor modulator (SARM).

      No I’d actually recommend a pill of RED-PCT or Arimi-RX PCT alongside RAD-140.

      1. ok, so ive used osta-red and found that it helped me put on mass. I gained weight 5-15 in two 8 week runs of it, while having cals around maintenance or below. Is this similar to that SARM?

  5. You said that RAD140 will not cause the prostate enlargement that supplementing with testosterone can. However, can taking an 8-week cycle of RAD140 help lower a slightly high PSA score by reducing prostate size or inflammation?

    1. I don’t think it will directly reduce prostate size, it simply won’t put you at risk of enlargement like Testosterone might. If the root cause of your prostate enlargement is from Testosterone, then the only way to mitigate that would be to come off of the Testosterone, lower the dose, or find another alternative method of combatting the problem. Indirectly it could reduce prostate size I suppose because you may be able to get away with a lower dose of Test alongside RAD-140 to achieve the same anabolic benefits as a higher dose of test on its’ own that would pose a higher risk of prostate enlargement.

  6. Hi
    I’m taking rad since five weeks now. I’m not sure to know if I can eat right after taking it in the morning ? Should I wait ? I usually take it and eat prot and carbs and go one hour after to the gym. What do you think ? Thanks

    1. Depends on your individual response to it, but I’d say in general yes. It will suppress you more though too.

  7. Can i take this and take my massive muscle shake too ? I am lean . Whenever i hit the gym i get the cuts but my muscle just wont grow faster .

    1. Why wouldn’t you be able to? You’re asking if you can ingest a certain type of food once you start RAD? Do you think RAD is going to have a chemical reaction with your shake or something? You’re fine dude.

  8. Hi Derek,

    So I ordered a bottle of Rad140 and Cardarine (Liquid forms) and also Clomid pills for PCT. I know Cardarine can be run longer for about 12 weeks, then off another 4 weeks or so and be retaken. I’m not sure how long Rad140 can be run…I’m assuming 10 weeks for best results at 20-30ml per day.

    With your experience from Rad140, how much muscle mass did you gain over your Cycle period? I know It’s not a huge muscle builder compound and results will vary from people to people.

    1. I don’t know exactly how many pounds was lean muscle. Typically if I bulk, I gain 20-30 pounds over the span of 12-16 weeks, but obviously not all of that is muscle.

  9. So i’ve been researching on RAD140 online and through forums….others say pill forms are not the same as Liquid forms? Can you vouch for EA’s Rad140 Derek…is this product legit or are liquid forms better….also running a Rad140 cycle for 12 weeks.. would you recommend both Nova and Clomid or would Clomid be sufficient enough?

    1. The only guys who say that liquid SARMs are better are guys who sell liquid SARMs. Not a coincidence.

      Capsules or liquid, it’s irrelevant, they work exactly the same. The compound is in powder form. Whether someone decides to cap that powder, or suspend it in grain alcohol liquid, it doesn’t matter, it will do the exact same thing once it is ingested.

      Yes I’ve used EA’s RAD-140 and it is legit.

      Clomid would likely be sufficient for a solo RAD-140 cycle.

  10. Sup Derek,

    I’ve never done any PED’s in my life, currently at 170lbs and wanna get down to maybe
    160lbs. I’ve heard Rad 140 is alot like Turinabol, where you can gain some good size but not too much. With your experience on Rad140, lets say I run 8-10 week cycle and I gain 6-7 lbs of muscles, how much of that can be retained after going off cycle?

  11. Sup Derek,

    I’d like to lose some fat more rapidly. I was thinking bout stacking Cardarine and MK677 together. I know like you said it’s not the best cause it gives you hunger, but hopefully I can control it and eat at my caloric maintanence. I have a pretty good foundation, been lifting for 15 plus years….5’7 weigh in about 170lbs..maybe want to get down to 155 lbs. Stacking these two, will I need to run anything like n2guard…I was thinking maybe running Blue Ox along just for benefits.

    With your experience, If i shed those pounds, will my muscles look a little more full…I have this layer of fat, that’s been very hard to shed off, even with a pretty strict diet, so i was hoping this would put me over the edge and remove the access fat.

    1. It will be incredibly difficult to not overeat on it, I assure you.

      Also, if you want to lose 15 pounds, you should NOT be eating at maintenance. Checkout my get shredded for beginners article if you need guidance on dieting, you won’t lose any weight not eating in a calorie deficit.

      You don’t need to run n2guard or Blue Ox with them, Cardarine and MK-677 don’t affect the endocrine system at all.

      No, your muscles won’t look more full if you lose 15 pounds, you will look leaner and more defined though of course. Depriving your body of calories and losing weight will never result in fuller muscle bellies, that is contrary to the entire process that is taking place via fat loss. Glycogen will get sucked out of your muscles as your body feeds on stored energy, and you will be flatter.

  12. I am new to sarms and I am getting ready to run rad 140 at 20mg for 4 weeks. I am running at a caloric maintenance. I am wondering what kind of gains I am preparing to see. Since I am overweight
    5’9 and 215lbs

    1. 4 weeks is too short to gain anything substantial, and eating at maintenance you won’t be doing much for yourself either. You are overweight, you need to cut.

      Use something less suppressive, eat in a calorie deficit, and get lean, and give yourself a sufficient time frame to do it in. Trying to gain muscle off of an overweight foundation is a recipe for disaster.

      Watch this:

  13. Hi,
    Not trying to ask too many questions and disturb you.
    I have a friend who is around 5’6 and 140 lbs he is also new to sarms and he wants to gain as much muscle as possible in a short 5-6 week cycle. He has got a diet prepared for this cycle aswell what sarm (s) do you recommend and at what dosage.
    Thanks your really helpful

  14. Out of ostarine and Rad140 which would give more strength per lb of lean mass gained? Looking to gain most amount of relative/lb for lb strength. Thanks

      1. Not sure if this would help you answer the question but what if the user is fast twitch dominant? Would that make them favorably respond to one over the other?

  15. Hey Derek,

    Is this the Sarm you would recommend for athletes mainly looking to increase speed/explosiveness? Thanks!

  16. Just got my rad and osta today, waiting on arimi for pct. Can i take 20mg of rad and osta in the a.m. at the same time? And would you recomend taking arimi while on this stack? Btw i used your discount code.

    1. Yes.

      I’d take a pill of Arimi-RX alongside it each day but it’s more of a precautionary measure than a necessity.

      1. Thanks for the reply.

        What other sarm could i add to this? Im currently 200lb and trying to lean out. Im around 14% bf.

  17. I’ve read many reviews on rad that talk about it enhancing speed but none with lgd. Does rad provide effects on speed that LGD does not?

    1. Hard to say as I don’t train for speed, so I couldn’t say for sure if LGD wouldn’t stand up as well in the speed boosting category.

    1. My answer would be an educated guess, so I’m not exactly sure. It would at minimum be the entire clearance time of the compound based on its’ half lives though.

  18. A lot of people have mentioned increased speed as part of the RAD140 experience, Can you speak to that a bit more?

  19. James Larcombe

    Hi man I’m 17 and was wondering if it would be safe for me to use rad 140 as I am nearly 18 and that is the recommended age in England.

    Thanks a lot,

    1. It wouldn’t necessarily be unsafe, but that call isn’t for me to make dude. Typically guys at your age don’t even have a fundamental understanding of diet or training, so embarking on a cycle is in almost all cases a big mistake. Do adequate research before you even consider doing anything is my suggestion.

  20. Hi, I have a friend who is looking to get into mma/boxing/kickboxing what sarms would you reccomend take into consideration that this is to gain: strength, endurance and explosiveness but without putting on very much size since he will need to cut down at a later date.

  21. thank you for all of your hard work in organizing and publishing this information……I’m trying the “cutting stack” you recommended in the article (on my rat)…….(and I’m using Aromasin instead of Arimi-RX)

    A couple questions:

    Which items on the list, if any, can be taken/researched year round? (probably at least Aromasin)

    If a rat has a specific event such as a photo shoot, show, etc., which items on the last can be taken throughout that period, and which items if any should ideally be cut out for a period of time prior to the event?

    1. I don’t suggest taking anything year round. You need to take a break from them eventually. Even AI’s aren’t fantastic for your lipids, so those should have breaks as well unless you’re on HRT and need one to stay at a healthy level of Estrogen.

      None of these compounds need to be dropped prior to the photoshoot as they won’t retain water (even RAD140 I overestimated how wet of a compound it was initially).

  22. Good day Derek,
    I have a friend who is recomend me with QUAD ELITE stacked with RAD-140, 1 cap at 1 am and 1 cap at 1pm for Quad elite same for rad-140 or combine.
    Actually, my weight was 60kg before i starting gym february several months ago and now my weight is 65kg with a bit muscle. I spent time 2 too 3 hours at the gym to gain muscle every day and/or active for 7 days.
    Please any comments of advices or any recomendation. Thank you.

    1. I don’t know what “quad elite” is so I can’t help you on the dosing for that. As for the RAD140, you didn’t mention your RAD140 dose, planned cycle duration, or your goals for the cycle. Do you have your PCT on hand already before you start your cycle?

  23. sup, derek

    is that ok to take mk677 for like 8-10 weeks and rad140 ,only for 4 weeks, together and then take pct with clomid?

  24. Derek,
    I am currently 3 days into taking RAD140 and I’ve noticed that my left nut is absolutely killing me. I have stopped taking it and because it feels like my nut was just hit. How long does this pain normally last? Thanks man I appreciate any feedback you have.

    1. 99% of people don’t get testicle pain so I couldn’t tell you how long it will/won’t last. That is dependent on your body’s response.

  25. Hey Darek,

    I am getting ACNE on my shoulder and slightly on my chest and back, I am on day 4 on RAD 140, MK 677, Cardarine and S4 I am running a cutting cycle. From what I’ve read in your post it seems RAD 140 gives me acne, but on some other posts, I have also read that it will go away.

    I have two questions;

    1. What can I do or take perhaps PCT to reduce my acne?
    2. How long can I run my cycle, is it dangerous to have this acne or can I continue, I mean I have already taken my personal records in terms of strength in gym and muscle fullness also the cutting goes well.

    1. 1. You could have elevated Estrogen levels relative to your test levels (SARMs will suppress your test) which can cause acne. Get Arimi-RX and start using 1 pill of it per day to offset Estrogen related side effects. Use discount code DC15 to save 15% on your order.
      2. I wouldn’t exceed 12 weeks. Your acne isn’t dangerous, acne is acne. You got it when you hit puberty too probably and it wasn’t dangerous then either.

  26. Hey derek! I am planning to run rad 140 and mk 677 for 10-12 weeks, you think it is optimal if i want to put on some size and mass? And is it more successive than lgd 4033? Thanks!

    1. It’ll do the trick if you eat enough, rest enough, and train hard enough. I don’t think it’s better than LGD-4033 for putting on size though.

  27. What PCT do you sugges I take after a 8 week cycle of RAD140 and mk677 at 20 mg a day???

    Thanks for the help man

  28. First and foremost, the info provided for RAD-140 is definitely appreciated. My question to you is being that I’m on doctor prescribed TRT, at the end of a 8 to 12 week cycle of 20 to 30mg is a PCT even needed? If not could I just wait another 8 to 12 weeks before utilizing it again?

  29. Hi m8.
    On the beginning I’m delighted to read articles as your. Thank for help for everyone!
    I’m thinking about 2nd cycle of sarm (ostarine was 1st) and my goal is to put some muscle. Which sarm will do better for this lgd or rad and why?
    Thanks in advance.

    1. LGD-4033 because it’s just the overall best mass building SARM imo. RAD-140 is close, but LGD-4033 most typically respond pretty well to. Ultimately it is up to you, you can’t go wrong with either, they serve the same purpose.

  30. Would you recommend stacking rad 140 with LGD or is that an overkill? have used them before stacked with ostarine.

  31. Derick, have you had blood work done for lipids right after a RAD-140 cycle? I’m hearing from a select few that it can trash lipids pretty bad at 20 to 30mg a day.

    I’m going to get my lipids checked after I’ve been on RAD for at least a month.

  32. For the “cutting stack” you outlined, if one were to use the liquid Exemestane instead of the Arimi-RX PCT pill, what would a possible dosage protocol be for the test rat? …..thanks, Derek

    1. I wouldn’t use Aromasin at all with SARMs, there is no sense in it unless you genetically have very high Estrogen levels. Aromasin is too strong of an AI to run with compounds that don’t aromatize into Estrogen imo.

  33. my athlete just started taking rad 140 , 20 mg daily for 8 weeks ( on day 2 ) when can he start to see or feel results from the rad in terms of performance.

    athlete is a recreational weightlifter ( olympic style ) just wanting to see what his body can achieve stats are 5’10” 170~180 lbs body weight , major lifts are squat 420lbs , 517 deadlift , 210lbs snatch 300lbs clean and jerk .

    I understand most of the gains will be made from a technical point but from a strength point of view should this sarm help get the athlete out of the slump / plateaux ?

    1. You won’t necessarily “feel” anything.

      It typically kicks in after a week or so.

      Yes it will help bust through a strength plateau if you are eating enough/properly and training hard.

      1. MK2866 – 30mg ed
        SR9009 – 10mg ed x 4
        RAD140 – 20 mg ed
        S23 – 25mg ed

        Plan to run 6 weeks
        500 daily caloric deficit – super clean diet
        6 days a week working out (4 days weights and 2 cardio)
        TRT 250mg cyp wkly (w/ HCG and AI), so no PCT.
        6’7″ 275lbs.


        1. I’d use Cardarine at 20mg per day instead of SR9009 personally. The rest looks solid. I’d do more cardio than that though too. You could also throw in the new DIABLOZ fat-burner that EnhancedAthlete.com sells to expedite things a lot more as well fat loss wise. Discount code DC15 will save you 15% on it (or anything else on the site).

  34. Which is less suppressive…Ostarine or Rad 140? Want to run one of them for 8-12wks around 15mg Ostarine or 10mg rad.

    Would a pct be recommend for Ostarine at that dose? Still clomid or red-pct?


    1. Ostarine. 15mg of Osta would be more productive than 10mg of RAD-140.

      PCT is up to you not up to me. You can likely recover with just Arim-RX, but I always go for Clomid because I don’t want to chance things.

  35. Hi. I have recently dropped about 20lbs cutting naturally. Unfortunately i lost more muscle mass than I’d like. I’m going to start a stack with the goal of staying lean (leaner would be nice) but put back on 5-10lb quality muscle. Thinking rad, Gw, and S4. Thoughts?

    1. I think GW is a waste during a bulk unless you need it for cardio purposes. I’d pick LGD-4033 and RAD-140 personally. Add MK-677 into the mix if you want to max out the potential of the cycle.

      Here is the best deal going at the moment for what I just mentioned: https://scottssupplements.com/product/dereks-bulking-stack/ (discount code DC15 will save you an addition 15% off your entire order at checkout). I’d get 2 or 3 of these (depends on the length of your research).

      1. I was thinking of keeping RAD140 low because I am stacking it with Ostarine and from what I’ve researched is more of the most suppressive SARMs (excluding S23). I wanted to shed more body fat on this cycle (and preserve muscle mass) so do you think it is necessary to dose it any higher when stacked with standard dosages of Ostarine? I feel like I would be risking significant suppression/shut down if I dose RAD140 at the standard 20 mg ED.

        1. Ah ok gotcha. If you want to avoid significant suppression/shutdown then what you are doing is a good strategy.

          What you have it dosed at now should be sufficient to maintain your lean tissue during your cut anyways with the Osta in there.

    1. You don’t “need” to take anything. These are research chemicals with no concrete set in stone rules regarding what/what not to do.

      I would take 25mg of Arimistane on cycle to offset the potential for high Estrogen related issues personally.

  36. Hey bro, I freaking love Rad and I was wondering if I could take it year round? I really don’t want to stop because I feel so good on it and love the effects. I really don’t care about suppression because I am on testosterone replacement pellets (biotee) already. Is this a bad idea to keep going and stay on it year round? Thanks for your time man.

    1. That’s a personal decision that should be made based on your personal health markers, not from some random guy saying yes or no to you on the internet. I have no idea what your blood work looks like. For all I know RAD could be wrecking your lipid profile long-term (probably not, but hey I don’t have a crystal ball). You’d have to see how it is affecting your health (if at all) before you decide if it’s something you can run that long-term.

      1. No, I get it. It just sounds like something that really doesn’t have any side effects and could be used as a test replacement, so my thinking was, why not? I havnt heard of anyone doing it long term and just wanted to see if it was possible. I have been running it 3 months and feel great. No noticeable side effects whatsoever. Have not got bloods done, but I feel great. Thanks again for your time bro. I appreciate your work.

  37. If you run the cycle for 12 weeks. Run a short PCT. How long would you generally recommend to wait until starting another cycle?

    Appreciate your time and answer.

  38. Hey Derek i have a quick question that I don’t think you covered. Are the gains from Rad 140 permanent assuming one keeps the same diet and workout regiment like anavar? Or will most of the gains be lost? Because you did mention that you will retain some water. Also, I plan to do a 12 week 20mg a day rad only cycle. You do not suggest nolva and Clomid for pct or will Arimi-RX be just enough?

  39. Hey,

    I’m currently taking Ostarine MK-2866 @20mg a day ( I’m on my second week ) of a 12 week cycle.
    I’m about to stack Rad-140 at 20mg for 8-10 weeks. Many experienced anabolic as well as SARM users have told me no PCT is necessary.. what are your thoughts? after this cycle I dont plan on running for at least two-four months, if I even need to run again I heard the gains are pretty maintainable.

  40. Hello there. I am just curious: if RAD-140 has a such a low androgenic index, why would one have a dip in test levels afterward, to the extent of having to do PCT?

    Thanks for your time.

    1. How androgenic a compound isn’t indicative of how suppressive it is. There are plenty of steroids with fairly low androgen ratings that will shut you down just like something else would that has a sky high androgen rating. It causes a dip in test levels because it suppresses your endocrine system.

  41. Im 46, and had been 225lbs reasonable fat levels, 5 10, and vegetarian before any sarms, so my test is obviously running fine. I have awesome source here as he is a supplier manufacturer of sarms. I had tried rad 140 at a low dose fof my 1st go, like 20mg day, and my weight and size shot way up. Over 9 lbs in 3 weeks. I don’t want the EXTRA size, more the recomp of hardened,tighter muscle, strength increase, joint health, and the like.

    What Sarm would you recommend for me? Ostarine came to mind, but I have limited real world experience with sarms.

    Thx much.

    1. You’re 46 years old. Without blood work you can’t say for certain where your test levels are at. Especially at an age where they are more than likely suboptimal.

      In terms of the goals you’ve outlined (not accounting for your age or the fact that I’d advise blood work analysis first), I agree that Ostarine would be the most fitting.

  42. Hey Derek,

    Just about to start my Rad 140 in pill form and wondering if I need to take sublingual or just swallow them.

    Thanks !


  43. Hey Derrick,
    I’m in my off season right now (football) and am about to do a cycle of LGD4033 10mg/day with MK677 20mg/day to gain weight and strength. After this cycle and appropriate PCT, I was going to run RAD140 20mg/day during my season. Would this be beneficial to sequence these sarms in this order? I figured RAD140 was a more performance based sarm. Thanks!

  44. Hi Derek,

    wondering RAD 140 it is work with LONG DISTANCE RUNNER? mean ultra MARATHON, 100miles to 150miles, probably the race will took 60hrs…. how much LONG LIFE for RAD 140? 16hr? after 16hr shall i continue another tablet?

    1. Cardarine is far better for endurance purposes. I feel like adding muscle mass with RAD-140 would just increase your oxygen needs as you will have more muscle tissue, which may negatively impact your marathon times.

  45. Hey Derek. Love your website mate. Great information here.
    About to finish a solo cycle of ostarine.
    Going to PCT for 4 weeks on 50/50/25/25 mg Clomid.

    Immediately after finishing PCT,I’m thinking of doing a 12 week cycle
    Week 1-8 (Eat in a 500-800 calorie surplus)
    25mg Ostarine per day
    20mg RAD-140 per day

    Week 9-12 (Aggressive Cut (500-800 calorie defecit)
    25mg Ostarine per day
    20mg RAD-140 per day
    20mg Cardarine per day
    Throw in some Mt2 for appetite suppression + tanning

    Week 13-14
    Clomid 50mg per day

    Week 15-16
    Clomid 25mg per day

    How does this sound?
    I’m not 100% sure on if it’s safe to restart a cycle straight away again
    I’m also not sure if my PCT is sufficient, or if this will also require Nolvadex

    Thanks mate, appreciate your help

  46. Hey, I’m a 200m sprinter and I’m wondering what sarm will work best for me? I’ve heard that gw would increase slow twitch muscle fibers

    1. GW is for endurance. Power/short distance speed would be obtained via certain anabolics (SARMs or AAS). RAD-140 is one that comes to mind.

  47. Hi I was wondering if u could give me any advise on a 10-12 week cycle iv got 2 bottles of ostarine 1 lgd and 1 rad-140 what would be best to run them

  48. Need your 2 cent on an upcoming sarms cycle

    Main goal maybe gain 5lbs of muscle as dry as possible no wet gains

    Ive done previously mk 677 and rad

    Planning on running Osta,rad 140 low dose


    Osta 1-10 15mg-25mg
    Rad 140 1-10 10-20mg
    AlCar 2g before breakfast instead of GW

    Mini pct

    Clomid + tongkat ali 3weeks 50/50/50 tongkat @ 100mg a day

    1. What would you add to get an increase in lean muscle mass but not to much and be ripped,vascular,and have lots of muscle fullness, also dry gains as possible not wet gains

    2. how can I do this cycle without hair loss I’ve got lots of hair thinning on previous sarms cycle even with Ru58841

    What do you recommend, doing very low dose or not do ostarine and rad at all

  49. Im kinda doing my first cycle ever on Rad140 bro.
    With exams and everything. Im on one of the best universities of my country and i have some very good knowledge in pharmakinetics/biochemistry along with nutrition ish stuff.
    Just took my 1st pill. I will run my cycle as this:
    10mg – 1wk
    20mg – 2/3 wk.
    30mg – 4wk.
    Probably buying another bottle (since i have 60 caps)

    My question then is: it doesnt aromatize. alright. did you feel any nipple sensitivy as it would do some higher prolactin?

    And by what you said, you think my 4/5wk cycle would be not even close to good?

    Plus: Ill bump in some HCG (2500ui/2-3 times a wk). Do you think it’s a safe option?

    Both Ill decide when I get off from it and have another blood exam.

    Thanks in advance.

  50. Derek,

    Does Rad 140 affect sex drive in any way; also does it increase/decrease testosterone production? Would RAD 140 be like taking exogenous test or would it be more similar to something like clomiphene monotherapy which has some test like benefits?

  51. Hey Derek –
    Started Rad-140 about 3 days ago at 20mg per day; have a dull ache/pain in my right testicle. It comes and goes. is that due to suppression? I read on many sites rad was not that suppressive but lately hearing differently. I am not too keen on a complete shut down.
    Also, what type of PCT do you recommend for Rad only? Was planning on 6-8 weeks run at the 20mg mark. I was going to run Reduce XT and Rebirth for my PCT.
    Lastly, should i run a Arimistane suring my rad cycle?


  52. Hey Derek! I have been put on trt by the doctors perscription & i take nebido injektions every 12th week, to put me into my ”natty” testosterone levels. I was wondering if it is possible to blast with SARMs (8-12 week cycles) like the rad 140? The nebido injektion is also like a long type lasting testosterone, if you have heard of it?

    Also keep up with the great content!

  53. Hey Derek,

    Good write up! I recently did an 8 week cycle with RAD 140 + MK 677 and I’m really puzzled by your analysis that RAD 140 doesn’t cause the adverse side effects of TRT.

    My experience was that there was *significant* test suppression, male pattern hair loss, and some (mild) mood affects. The first two are IMO the worst side effects of TRT.

    Where you able to get your natural Test levels back online quickly after a cycle? I’ve been using Tamoxifen and Exemestane in a PCT cycle but after 2 weeks I don’t feel the test coming back on and it’s becoming problematic (relationship etc).

    Couple questions I’m hoping you might have had experience fielding:
    – Can RAD 140 not be used continuously to treat low test the way a traditional TRT regiment would be used?
    – What’s your recommended PCT and how much time have you observed that it takes to kick in?

    Thanks a lot of taking a look at this, much appreciated!

  54. hello derek
    i just got my rad 140 liquid and the liquid is so thick and white idk if it’s supposed to be like this or it’s just defective .
    thanks in advance

    1. I’m not sure man, I’ve never had anything like that. Could just be the color and viscosity of the carrier solution they used, could also be that the vehicle isn’t suspending the RAD140 properly.

  55. Hi Derek,

    Im actually doing a bulking cycle with:
    – 20mg Rad-140
    -10mg LGD-4033
    -20mg Mk-677
    I wanted to run 8 weeks of that cycle and then 1 month of cutting followed by pct. What do you suggest for the cutting cycle ? Should I keep RAD-140 add S-4 and cardarine.

  56. I’ve been trying to figure out dosages with testolone. I keep reading that 10-30mg a day is the zone to be in. The issue is that the droppers are in decimal. Are these 10-30mg a day recommendations intended to have been .10-.30mg dosages or are we going to spend $50 to $100 a day on kicking back entire bottles?

  57. Great analysis

    I am on RAD140. Albeit I have put on around 5 pounds of muscle and size, it is destroying my libido. My test and estrogen levels are very comparable to yours and I’m also on 100 mg of test cypionate. Prior to the implantation of RAD140, my sex drive was high, but has tanked since starting RAD 140.

    I don’t have any Noladex or clomid as I didn’t know where to get some, but did purchase a product called Red-PCT anti-estrogen supplement.

    Thanks for all that you do.

  58. On trt and started rad-140. I have some injuries that I’m addressing and was curious about using ostarine. Is it safe to stack with rad 140 at reasonable dosages or should I only use 1 at a time?

    Thanks for all your content

  59. So with the half life actually being 60 hours as opposed to 24 as previously thought, how would that affect dosage? What would someone recommend for changes to researching an 8 week cycle?? Thanks in advance!

  60. Hey so I was thinking about doing an 8 week cycle of Rad 140 at 20mg/week alongside MK 677 at 10mg/week.

    Do you think it is necessary to PCT with Nolva and Chlomid?

    Are there any legal alternatives to a PCT since it is difficult to obtain these two?

  61. Hey Derek, what is your opinion on using clomid to keep endogenous testosterone up while doing a sarms cycle? I’m currently subscribed clomid and take it every day to keep my testosterone up around 900ng/dl, just wondering if this would be just as effective as a test base for a sarms cycle.

  62. Hi Derek, I’m on week 6 of my cycle (10mg / day) and my joints are killing me. Do you have any advice how to manage this?

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